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Database: UniProt
Entry: D9WAH2_9ACTN
LinkDB: D9WAH2_9ACTN
Original site: D9WAH2_9ACTN 
ID   D9WAH2_9ACTN            Unreviewed;       259 AA.
AC   D9WAH2;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   26-FEB-2020, entry version 38.
DE   SubName: Full=2 superfamily AP endonuclease {ECO:0000313|EMBL:EFL26913.1};
GN   ORFNames=SSOG_06627 {ECO:0000313|EMBL:EFL26913.1};
OS   Streptomyces himastatinicus ATCC 53653.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=457427 {ECO:0000313|EMBL:EFL26913.1, ECO:0000313|Proteomes:UP000003963};
RN   [1] {ECO:0000313|EMBL:EFL26913.1, ECO:0000313|Proteomes:UP000003963}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 53653 {ECO:0000313|EMBL:EFL26913.1,
RC   ECO:0000313|Proteomes:UP000003963};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "Annotation of Streptomyces hygroscopicus strain ATCC 53653.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the hyi family. {ECO:0000256|PIRNR:PIRNR006241}.
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DR   EMBL; GG657754; EFL26913.1; -; Genomic_DNA.
DR   EnsemblBacteria; EFL26913; EFL26913; SSOG_06627.
DR   eggNOG; ENOG4105IMJ; Bacteria.
DR   eggNOG; COG3622; LUCA.
DR   HOGENOM; CLU_050006_1_2_11; -.
DR   Proteomes; UP000003963; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR026040; HyI-like.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PIRSF; PIRSF006241; HyI; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000313|EMBL:EFL26913.1};
KW   Hydrolase {ECO:0000313|EMBL:EFL26913.1};
KW   Isomerase {ECO:0000256|PIRNR:PIRNR006241};
KW   Nuclease {ECO:0000313|EMBL:EFL26913.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003963}.
FT   DOMAIN          47..218
FT                   /note="AP_endonuc_2"
FT                   /evidence="ECO:0000259|Pfam:PF01261"
FT   ACT_SITE        141
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006241-50"
FT   ACT_SITE        239
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006241-50"
SQ   SEQUENCE   259 AA;  27817 MW;  3452E71B1B17028F CRC64;
     MSPFTLAASA EMLYLDLPFT ERVRRIADQG FQVEIWDWSA KDIDALAATG ATFSSMTGYL
     TGDLTEPDGI EALLASARKS LDVAAQLDCP RLNLHGTGLD PQGLPVRPVH DVTPTMWLTA
     ADTLRRIAAL GEEADRVFTL ENLNLAVDHP GTPFARAADT LALARAVDSP HLRLNLDLYH
     AQIGEGNLID LLGQALPYVG EIQVADVPGR CEPGTGEIHY PAIAAALHDL GYTGVVGLES
     WARHDPDTAL DAFRAAFTP
//
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