ID   D9WSV7_9ACTN            Unreviewed;       384 AA.
AC   D9WSV7;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Acetoin utilization protein AcuC {ECO:0000256|ARBA:ARBA00020218};
GN   ORFNames=SSOG_03946 {ECO:0000313|EMBL:EFL24232.1};
OS   Streptomyces himastatinicus ATCC 53653.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX   NCBI_TaxID=457427 {ECO:0000313|EMBL:EFL24232.1, ECO:0000313|Proteomes:UP000003963};
RN   [1] {ECO:0000313|EMBL:EFL24232.1, ECO:0000313|Proteomes:UP000003963}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 53653 {ECO:0000313|EMBL:EFL24232.1,
RC   ECO:0000313|Proteomes:UP000003963};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "Annotation of Streptomyces hygroscopicus strain ATCC 53653.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Ketone degradation; acetoin degradation.
CC       {ECO:0000256|ARBA:ARBA00005101}.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family.
CC       {ECO:0000256|ARBA:ARBA00005947}.
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DR   EMBL; GG657754; EFL24232.1; -; Genomic_DNA.
DR   AlphaFoldDB; D9WSV7; -.
DR   STRING; 457427.SSOG_03946; -.
DR   HOGENOM; CLU_007727_8_0_11; -.
DR   UniPathway; UPA00040; -.
DR   Proteomes; UP000003963; Unassembled WGS sequence.
DR   GO; GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd09994; HDAC_AcuC_like; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR003085; AcuC.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01272; ACUCPROTEIN.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Acetoin catabolism {ECO:0000256|ARBA:ARBA00022627}.
FT   DOMAIN          16..310
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
SQ   SEQUENCE   384 AA;  41284 MW;  3236C152CA6E1867 CRC64;
     MMWDEEVTGY DFGAGHPMDP VRLALTMRLV EAFGLDRAVE VVAAKAAGDS TLRLVHRQEY
     IEAVRRASAD PAGADGSYGL GTMDDPAFAG MHEASALIAG QSVGAAESVW RGEALHAVNF
     AGGLHHAMPG GAAGFCVYND AALAVARLLE LGAERVAYVD VDVHHGDGVQ AAFWDDPRVL
     TISLHEHPRT LFPQTGWPEE TGGQGAEGSA VNVALPAGTG DAGWLRAYHA VVPELLAAFR
     PQVLVTQHGA DTHIEDPLAH LGVTVDAQRA VAESCHRLAH EYADGRWVAL GGGGYAVVEV
     VPRSWTHLVA IAAGRPVAPE AEVPEEWRHE VYRRTRLEAP RRMTDGREPR WQDFAESGYD
     PADRLDQAIL ATRRAVFPHR GLLP
//