ID D9WTX6_9ACTN Unreviewed; 635 AA.
AC D9WTX6;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN ORFNames=SSOG_01936 {ECO:0000313|EMBL:EFL22224.1};
OS Streptomyces himastatinicus ATCC 53653.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX NCBI_TaxID=457427 {ECO:0000313|EMBL:EFL22224.1, ECO:0000313|Proteomes:UP000003963};
RN [1] {ECO:0000313|EMBL:EFL22224.1, ECO:0000313|Proteomes:UP000003963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53653 {ECO:0000313|EMBL:EFL22224.1,
RC ECO:0000313|Proteomes:UP000003963};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces hygroscopicus strain ATCC 53653.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC {ECO:0000256|ARBA:ARBA00009348}.
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DR EMBL; GG657754; EFL22224.1; -; Genomic_DNA.
DR AlphaFoldDB; D9WTX6; -.
DR STRING; 457427.SSOG_01936; -.
DR HOGENOM; CLU_430157_0_0_11; -.
DR Proteomes; UP000003963; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd00110; LamG; 1.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13088; BNR_2; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00560; LamGL; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..635
FT /note="exo-alpha-sialidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003131547"
FT DOMAIN 466..606
FT /note="LamG-like jellyroll fold"
FT /evidence="ECO:0000259|SMART:SM00560"
FT DOMAIN 466..601
FT /note="Laminin G"
FT /evidence="ECO:0000259|SMART:SM00282"
FT REGION 615..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 67910 MW; F8E74CD205577E03 CRC64;
MLLAAAALAL TPLPVRAADT DDTVSAARTA SGSSADADAD FDQQILFKSG QDGGYFCFRI
PAIVKSKDGT LLAFAEGRKD NCGDAGDIDL VLKRSADGGR TWGPLQVVNE GGGDTHGNPA
PVVDTRTGRI LLASTYNTGR DDSQSCDVPC DRTPHLQYSD DDGATWSTPR DLSPALLPPA
WNSWYATGPV HGIQLKRGPH KGRLLFTVNT ESHDGTRITA NHAALAYCDD GGRRWKVGAV
DSYPIAQDGT FRQKPSEMTL LERSDGSVYV NGREQDGTDL GHRDYAISHD GGESFAAPFR
TIPDLSTPMV QGSVLRLRDA GRDGPGRLLF AAPADPDRRR TMMIRSSWDE ARSWEGTDRG
KVVTTDWSGY SDMALISPGT VGLMYEGGAV DARDEIRFAR FSEDWLGPRA APSPVTDDRA
PRARPATVLG GATGTAGGRF GGALTFDGTD DAVRLPYRSS LPLGTRDFTI SLWFRYSAAS
GQHPFLWMGG IGGKQAQVWV RGEPSANRVR ALMTTVNGPA TYTSASVSTT AAHNDGAWHH
LALTRTGGRL SLTVDGTAPV SAPDAPGTIS RSSPFALHLG EAVDGRSRMT GALDEVRVYG
RALTDTELRR VREFNAPAGK SATTHLPLDR VRSPR
//
