ID   D9XZV4_9ACTN            Unreviewed;       793 AA.
AC   D9XZV4;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=beta-mannosidase {ECO:0000256|ARBA:ARBA00012754};
DE            EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
GN   ORFNames=SSRG_01197 {ECO:0000313|EMBL:EFL38393.1};
OS   Streptomyces griseoflavus Tu4000.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=467200 {ECO:0000313|EMBL:EFL38393.1, ECO:0000313|Proteomes:UP000002968};
RN   [1] {ECO:0000313|EMBL:EFL38393.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tu4000 {ECO:0000313|EMBL:EFL38393.1};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "Annotation of Streptomyces griseoflavus strain Tu4000.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC         in beta-D-mannosides.; EC=3.2.1.25;
CC         Evidence={ECO:0000256|ARBA:ARBA00000829};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC       {ECO:0000256|ARBA:ARBA00007401}.
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DR   EMBL; GG657758; EFL38393.1; -; Genomic_DNA.
DR   RefSeq; WP_004923680.1; NZ_GG657758.1.
DR   AlphaFoldDB; D9XZV4; -.
DR   STRING; 467200.SSRG_01197; -.
DR   eggNOG; COG3250; Bacteria.
DR   HOGENOM; CLU_005015_3_2_11; -.
DR   OrthoDB; 9758603at2; -.
DR   Proteomes; UP000002968; Unassembled WGS sequence.
DR   GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProt.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR   PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR   Pfam; PF00703; Glyco_hydro_2; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          234..281
FT                   /note="Glycoside hydrolase family 2 immunoglobulin-like
FT                   beta-sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF00703"
FT   REGION          514..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   793 AA;  88358 MW;  8B8BDF6E702DB06D CRC64;
     MRQVTPLTEG WILRHPDGTG DALPASVPGC VHTDLLAAGL IPDPFLGRNE TEVAWVGRRE
     WTYETELTAG AGPHEQTDLV FDGLDTVAEI LLDGRPLGRT RNMHRSYRFD VTGLSGRLTV
     RFASAYAEAE AVRGRLGERP GAYAEPYQYL RKMACSFGWD WGPTLVTAGI WRPVRLERWS
     TARIARVRPL VTVEDGVGQI ELAVDVERSR VEAPLTLEAS AGGVRARARI DGTAGTVRLR
     VPDVRLWWPR GYGEQPLYDV ELTLSHGDEA LDAWRRRTGF RTVELDTSAD AHGTGFTLVV
     NGERLFARGV NWIPDDVFPS RITRERYRHR LEQAAGAGVD LVRVWGGGIY EDEDFYDACD
     ELGLLVWQDF PFACAAYPEE QPLRGEVEAE ARENVVRLMP HPSLVLWNGN NENLWGFRDW
     DWEQGLAGDS WGEGYYLGVL PRVVAELDPT RPYTAGSPWS GSWRHHPNDP AHGTHHSWEV
     WNRADYADYR RDVPRFVAEF GWQAPPAHAT LRRALPGEDP APDSPGMLHH QKAEDGNGKL
     ERGLARHFAV PEGDFDRWHY LTQVNQARAV AAGVEHWRSH WPVCAGTVVW QLNDCWPVTS
     WAAIDGDGRE KPLYHELRRL YADRLLTVRA DGDGLVVAAV NQSAEDWRGT LRLRRMSVDG
     APIAEAAPAL DAGGRTVAVV EVPVELLPDG PGEFLVADAD GVRAWHFPAP DREIPYPRPE
     FEVALAPDGI TVTARTLVRD LLLQADRLDP GARADRGLVT LLPGEEVTIG VRGWKTPDPD
     TARSALYCVE PTR
//