ID DBH_STRP1 Reviewed; 91 AA.
AC P0C0H3; P0A3H9; Q48XT4; Q9XB23;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE RecName: Full=DNA-binding protein HU;
GN Name=hup; Synonyms=hlpA; OrderedLocusNames=SPy_1489, M5005_Spy1223;
OS Streptococcus pyogenes serotype M1.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=301447;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX PubMed=11296296; DOI=10.1073/pnas.071559398;
RA Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA Clifton S.W., Roe B.A., McLaughlin R.E.;
RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX PubMed=16088826; DOI=10.1086/432514;
RA Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA Musser J.M.;
RT "Evolutionary origin and emergence of a highly successful clone of serotype
RT M1 group A Streptococcus involved multiple horizontal gene transfer
RT events.";
RL J. Infect. Dis. 192:771-782(2005).
CC -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC DNA to stabilize it, and thus to prevent its denaturation under extreme
CC environmental conditions. Seems also to act as a fortuitous virulence
CC factor in delayed sequelae by binding to heparan sulfate-proteoglycans
CC in the extracellular matrix of target organs and acting as a nidus for
CC in situ immune complex formation (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC {ECO:0000305}.
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DR EMBL; AE004092; AAK34289.1; -; Genomic_DNA.
DR EMBL; CP000017; AAZ51841.1; -; Genomic_DNA.
DR RefSeq; NP_269568.1; NC_002737.2.
DR AlphaFoldDB; P0C0H3; -.
DR SMR; P0C0H3; -.
DR PaxDb; 1314-HKU360_01265; -.
DR KEGG; spy:SPy_1489; -.
DR KEGG; spz:M5005_Spy1223; -.
DR PATRIC; fig|160490.10.peg.1300; -.
DR HOGENOM; CLU_105066_3_1_9; -.
DR OMA; NPRTREK; -.
DR Proteomes; UP000000750; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR CDD; cd13831; HU; 1.
DR Gene3D; 4.10.520.10; IHF-like DNA-binding proteins; 1.
DR InterPro; IPR000119; Hist_DNA-bd.
DR InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR PANTHER; PTHR33175; DNA-BINDING PROTEIN HU; 1.
DR PANTHER; PTHR33175:SF3; DNA-BINDING PROTEIN HU-BETA; 1.
DR Pfam; PF00216; Bac_DNA_binding; 1.
DR PRINTS; PR01727; DNABINDINGHU.
DR SMART; SM00411; BHL; 1.
DR SUPFAM; SSF47729; IHF-like DNA-binding proteins; 1.
DR PROSITE; PS00045; HISTONE_LIKE; 1.
PE 3: Inferred from homology;
KW DNA condensation; DNA-binding; Reference proteome; Virulence.
FT CHAIN 1..91
FT /note="DNA-binding protein HU"
FT /id="PRO_0000104982"
SQ SEQUENCE 91 AA; 9647 MW; 50C7119C6753BEF5 CRC64;
MANKQDLIAK VAEATELTKK DSAAAVDAVF STIEAFLAEG EKVQLIGFGN FEVRERAARK
GRNPQTGAEI EIAASKVPAF KAGKALKDAV K
//
