ID DCTN2_DROPS Reviewed; 380 AA.
AC Q28Y46;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=Dynactin subunit 2;
DE AltName: Full=Dynactin 2 p50 subunit {ECO:0000250|UniProtKB:Q7K2D2};
GN Name=DCTN2-p50 {ECO:0000250|UniProtKB:Q7K2D2};
GN Synonyms=Dmn {ECO:0000250|UniProtKB:Q7K2D2}; ORFNames=GA20943;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC plays a role in prometaphase chromosome alignment and spindle
CC organization during mitosis. May play a role in synapse formation
CC during brain development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC dynein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000305}.
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DR EMBL; CM000071; EAL26119.1; -; Genomic_DNA.
DR RefSeq; XP_001361541.1; XM_001361504.3.
DR AlphaFoldDB; Q28Y46; -.
DR SMR; Q28Y46; -.
DR STRING; 46245.Q28Y46; -.
DR EnsemblMetazoa; FBtr0279956; FBpp0278394; FBgn0080932.
DR GeneID; 4805079; -.
DR KEGG; dpo:4805079; -.
DR eggNOG; KOG3958; Eukaryota.
DR HOGENOM; CLU_049964_1_0_1; -.
DR InParanoid; Q28Y46; -.
DR OMA; RGYDMRG; -.
DR PhylomeDB; Q28Y46; -.
DR Proteomes; UP000001819; Chromosome 3.
DR Bgee; FBgn0080932; Expressed in female reproductive system and 2 other cell types or tissues.
DR GO; GO:1904115; C:axon cytoplasm; IEA:EnsemblMetazoa.
DR GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0005869; C:dynactin complex; ISS:UniProtKB.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR GO; GO:0061883; P:clathrin-dependent endocytosis involved in vitellogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007080; P:mitotic metaphase chromosome alignment; ISS:UniProtKB.
DR GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR GO; GO:0051028; P:mRNA transport; IEA:EnsemblMetazoa.
DR GO; GO:0016325; P:oocyte microtubule cytoskeleton organization; IEA:EnsemblMetazoa.
DR GO; GO:0007602; P:phototransduction; IEA:EnsemblMetazoa.
DR GO; GO:0045451; P:pole plasm oskar mRNA localization; IEA:EnsemblMetazoa.
DR GO; GO:2001019; P:positive regulation of retrograde axon cargo transport; IEA:EnsemblMetazoa.
DR GO; GO:0008090; P:retrograde axonal transport; IEA:EnsemblMetazoa.
DR InterPro; IPR028133; Dynamitin.
DR PANTHER; PTHR15346; DYNACTIN SUBUNIT; 1.
DR PANTHER; PTHR15346:SF0; DYNACTIN SUBUNIT 2; 1.
DR Pfam; PF04912; Dynamitin; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW Reference proteome.
FT CHAIN 1..380
FT /note="Dynactin subunit 2"
FT /id="PRO_0000288773"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..135
FT /evidence="ECO:0000255"
FT COILED 353..377
FT /evidence="ECO:0000255"
FT COMPBIAS 20..39
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 42136 MW; 386BCF12F74EAAFC CRC64;
MADPKFQNLP GIAYDQPDVY ETPDDPETDT SDYYEEEPEN EAIERMHISA SAAHKRFSGA
TLEGSVDFTD RIGRRPGRGY DMRGAGEYEL VGQGEKETPV QKCQRLQIEM NELLNEVAAL
QVDRKIADEE KQSYDAVATV ISTAKKVLDT LKLEQVLGKE QVPNSKQVKA LISQVEEFKQ
SGVLTAIPTP GTDLASTARV ASLEQRLYQL EKTVGAQPEK LSRLNAATNT TNVLEAVRQL
STKAALLQPD KLDTIEQRLT TLAGKMDSIA EKSSGSSQDA KRDQKISELY DIAKRTEPVV
EILPHVIERM QALESLHKYA NNFAKIIAEI EHKQGTITTS LVNNKELLHS VQETFAQNLE
TITNKVAKVE QRVTAISTAK
//
