ID DDRGK_BRAFL Reviewed; 298 AA.
AC C3Y431;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=DDRGK domain-containing protein 1 {ECO:0000305};
DE Flags: Precursor;
GN ORFNames=BRAFLDRAFT_114851 {ECO:0000312|EMBL:EEN65057.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82; TISSUE=Testis;
RX PubMed=18563158; DOI=10.1038/nature06967;
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- FUNCTION: May play a role in protein ufmylation and regulate different
CC cellular process. {ECO:0000250|UniProtKB:Q80WW9,
CC ECO:0000250|UniProtKB:Q96HY6}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q96HY6}.
CC -!- SIMILARITY: Belongs to the DDRGK1 family. {ECO:0000305}.
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DR EMBL; GG666484; EEN65057.1; -; Genomic_DNA.
DR RefSeq; XP_002609047.1; XM_002609001.1.
DR AlphaFoldDB; C3Y431; -.
DR SMR; C3Y431; -.
DR STRING; 7739.C3Y431; -.
DR eggNOG; KOG3054; Eukaryota.
DR InParanoid; C3Y431; -.
DR OMA; QEFIQYI; -.
DR OrthoDB; 197573at2759; -.
DR Proteomes; UP000001554; Genome assembly.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:1990592; P:protein K69-linked ufmylation; ISS:UniProtKB.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019153; DDRGK_dom-contain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR48176; DDRGK DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR48176:SF1; DDRGK DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF09756; DDRGK; 1.
DR SMART; SM01128; DDRGK; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Reference proteome; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..298
FT /note="DDRGK domain-containing protein 1"
FT /id="PRO_0000391854"
FT REGION 28..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 298 AA; 34270 MW; AAD02BB7DBA44E57 CRC64;
MVEPAVLYAV AAVFVAVLLF LAVKLRGGQE QQPADDGQRR GAPRPRTDAE RAAGAPRRVR
GARQRLQAAR RINQQDSEGD SDSDEGRPEI DIPEGMKVGA KKMKKLEMKA EKKAAREAAE
QEREERKQRE KMLEEKRKQE EEEEKLEEER RAEEERKAKE EKAAREHEEY LMMKEAFTVE
EEGHEEILDE DATENLLQDF IDHIKAVKVV LLEDLAAQFN MRTQDCIQRV QELREQGRLT
GVIDDRGKFI YISQEELQAV AKFIKQRGRV SITDLVESSN QLIHLIPDTE QVIRVQSS
//
