ID   DDRGK_DROVI             Reviewed;         307 AA.
AC   B4LYB9;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=DDRGK domain-containing protein 1;
DE   Flags: Precursor;
GN   ORFNames=GJ23857;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Substrate adapter for ufmylation, the covalent attachment of
CC       the ubiquitin-like modifier UFM1 to substrate proteins.
CC       {ECO:0000250|UniProtKB:Q96HY6}.
CC   -!- SIMILARITY: Belongs to the DDRGK1 family. {ECO:0000305}.
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DR   EMBL; CH940650; EDW66915.1; -; Genomic_DNA.
DR   RefSeq; XP_002053395.1; XM_002053359.2.
DR   AlphaFoldDB; B4LYB9; -.
DR   SMR; B4LYB9; -.
DR   STRING; 7244.B4LYB9; -.
DR   EnsemblMetazoa; FBtr0239782; FBpp0238274; FBgn0210952.
DR   GeneID; 6630124; -.
DR   KEGG; dvi:6630124; -.
DR   eggNOG; KOG3054; Eukaryota.
DR   HOGENOM; CLU_059562_1_0_1; -.
DR   InParanoid; B4LYB9; -.
DR   OMA; QEFIQYI; -.
DR   OrthoDB; 197573at2759; -.
DR   PhylomeDB; B4LYB9; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR019153; DDRGK_dom-contain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR48176; DDRGK DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR48176:SF1; DDRGK DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF09756; DDRGK; 1.
DR   SMART; SM01128; DDRGK; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal; Ubl conjugation pathway.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..307
FT                   /note="DDRGK domain-containing protein 1"
FT                   /id="PRO_0000391865"
FT   REGION          31..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  34112 MW;  B425313B36C555C2 CRC64;
     MDLILLVGIA TALLLILITL YFLQSKNAKT ETKAAAQPQR GVPQRAQEGV PRRAQIARNQ
     RNRLRQNQNA PAVAAAAAPA AAVDSDDDEA AAAGDENGPR VPQGAVLDEK MGAKKRAKME
     AKEQKRLQRE QELHDREQRK VKEAKEDAER KQQEDLDAEV ERKKAEADRL AKEERERKEH
     EEYLKMKAAF SIEEEGFEEG DADDKESLLA DFIQYIKDNK VVLLEDLATA FKLKTQQAID
     RIQELQENGT LTGVIDDRGK FIYVSEAELA AVAKFIKQRG RVSIAELAES SNNLINLTPV
     AAGESSA
//