ID DEFB1_MOUSE Reviewed; 69 AA.
AC P56386;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 24-JAN-2024, entry version 148.
DE RecName: Full=Beta-defensin 1;
DE Short=BD-1;
DE Short=mBD-1;
DE AltName: Full=Defensin, beta 1;
DE Flags: Precursor;
GN Name=Defb1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Marra M., Hillier L., Allen M., Bowles M., Dietrich N., Dubuque T.,
RA Geisel S., Kucaba T., Lacy M., Le M., Martin J., Morris M.,
RA Schellenberg K., Steptoe M., Tan F., Underwood K., Moore B., Theising B.,
RA Wylie T., Lennon G., Soares B., Wilson R., Waterston R.;
RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9287114; DOI=10.1016/s0014-5793(97)00875-2;
RA Huttner K.M., Kozak C.A., Bevins C.L.;
RT "The mouse genome encodes a single homolog of the antimicrobial peptide
RT human beta-defensin 1.";
RL FEBS Lett. 413:45-49(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RC STRAIN=129/SvJ, C57BL/6J, and FVB/NJ; TISSUE=Lung;
RX PubMed=10922379; DOI=10.1074/jbc.m006603200;
RA Jia H.P., Wowk S.A., Schutte B.C., Lee S.K., Vivado A., Tack B.F.,
RA Bevins C.L., McCray P.B. Jr.;
RT "A novel murine beta-defensin expressed in tongue, esophagus, and
RT trachea.";
RL J. Biol. Chem. 275:33314-33320(2000).
CC -!- FUNCTION: Has bactericidal activity. May act as a ligand for C-C
CC chemokine receptor CCR6. Positively regulates the sperm motility and
CC bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and
CC triggers Ca2+ mobilization in the sperm which is important for its
CC motility. {ECO:0000250|UniProtKB:P60022}.
CC -!- SUBUNIT: Monomer. Homodimer. {ECO:0000250|UniProtKB:P60022}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}. Membrane
CC {ECO:0000250|UniProtKB:P60022}. Note=Associates with tumor cell
CC membrane-derived microvesicles. {ECO:0000250|UniProtKB:P60022}.
CC -!- TISSUE SPECIFICITY: Detected in kidney. {ECO:0000269|PubMed:10922379}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AA071757; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AA065510; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AA108061; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AA107538; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AA105324; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF003525; AAB72003.1; -; Genomic_DNA.
DR EMBL; AF003524; AAB72003.1; JOINED; Genomic_DNA.
DR EMBL; BC024380; AAH24380.1; -; mRNA.
DR CCDS; CCDS40282.1; -.
DR RefSeq; NP_031869.1; NM_007843.3.
DR AlphaFoldDB; P56386; -.
DR SMR; P56386; -.
DR STRING; 10090.ENSMUSP00000051754; -.
DR PaxDb; 10090-ENSMUSP00000051754; -.
DR ProteomicsDB; 279364; -.
DR DNASU; 13214; -.
DR Ensembl; ENSMUST00000051017.9; ENSMUSP00000051754.9; ENSMUSG00000044748.9.
DR GeneID; 13214; -.
DR KEGG; mmu:13214; -.
DR UCSC; uc009lby.2; mouse.
DR AGR; MGI:1096878; -.
DR CTD; 1672; -.
DR MGI; MGI:1096878; Defb1.
DR VEuPathDB; HostDB:ENSMUSG00000044748; -.
DR eggNOG; ENOG502TDMV; Eukaryota.
DR GeneTree; ENSGT00940000166542; -.
DR HOGENOM; CLU_189296_1_0_1; -.
DR InParanoid; P56386; -.
DR OMA; CPLFTRI; -.
DR OrthoDB; 4335232at2759; -.
DR PhylomeDB; P56386; -.
DR Reactome; R-MMU-1461957; Beta defensins.
DR Reactome; R-MMU-1461973; Defensins.
DR BioGRID-ORCS; 13214; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Defb1; mouse.
DR PRO; PR:P56386; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; P56386; Protein.
DR Bgee; ENSMUSG00000044748; Expressed in prostate gland ventral lobe and 76 other cell types or tissues.
DR ExpressionAtlas; P56386; baseline and differential.
DR Genevisible; P56386; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:1990742; C:microvesicle; ISS:UniProtKB.
DR GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0019731; P:antibacterial humoral response; ISO:MGI.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
DR GO; GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; ISO:MGI.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IMP:UniProtKB.
DR GO; GO:0002227; P:innate immune response in mucosa; ISO:MGI.
DR GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; ISS:UniProtKB.
DR GO; GO:0009617; P:response to bacterium; IMP:UniProtKB.
DR GO; GO:0033574; P:response to testosterone; IEA:Ensembl.
DR InterPro; IPR001855; Defensin_beta-typ.
DR PANTHER; PTHR21388:SF9; BETA-DEFENSIN 1; 1.
DR PANTHER; PTHR21388; BETA-DEFENSIN-RELATED; 1.
DR Pfam; PF00711; Defensin_beta; 1.
DR SUPFAM; SSF57392; Defensin-like; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..32
FT /evidence="ECO:0000250"
FT /id="PRO_0000006925"
FT PEPTIDE 33..69
FT /note="Beta-defensin 1"
FT /id="PRO_0000006926"
FT DISULFID 37..66
FT /evidence="ECO:0000250"
FT DISULFID 44..59
FT /evidence="ECO:0000250"
FT DISULFID 49..67
FT /evidence="ECO:0000250"
SQ SEQUENCE 69 AA; 7749 MW; 8B12DBD3BBF3ACE4 CRC64;
MKTHYFLLVM ICFLFSQMEP GVGILTSLGR RTDQYKCLQH GGFCLRSSCP SNTKLQGTCK
PDKPNCCKS
//
