ID DIK1A_PONAB Reviewed; 428 AA.
AC Q5R634;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=Divergent protein kinase domain 1A {ECO:0000305};
DE AltName: Full=Protein FAM69A;
GN Name=DIPK1A; Synonyms=FAM69A;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9D6I7}; Single-pass type II membrane protein
CC {ECO:0000250|UniProtKB:Q9D6I7}.
CC -!- PTM: Among the many cysteines in the lumenal domain, most are probably
CC involved in disulfide bonds. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
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DR EMBL; CR860662; CAH92782.1; -; mRNA.
DR RefSeq; NP_001126623.1; NM_001133151.1.
DR AlphaFoldDB; Q5R634; -.
DR Ensembl; ENSPPYT00000001379.3; ENSPPYP00000001334.3; ENSPPYG00000001151.3.
DR GeneID; 100173620; -.
DR KEGG; pon:100173620; -.
DR CTD; 388650; -.
DR eggNOG; ENOG502QU5P; Eukaryota.
DR GeneTree; ENSGT00390000006452; -.
DR InParanoid; Q5R634; -.
DR OMA; YMRIKYL; -.
DR OrthoDB; 3996595at2759; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR InterPro; IPR029244; FAM69_N.
DR PANTHER; PTHR21093:SF4; DIVERGENT PROTEIN KINASE DOMAIN 1A; 1.
DR PANTHER; PTHR21093; UNCHARACTERIZED; 1.
DR Pfam; PF12260; PIP49_C; 1.
DR Pfam; PF14875; PIP49_N; 1.
DR SMART; SM01299; PIP49_N; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Endoplasmic reticulum; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..428
FT /note="Divergent protein kinase domain 1A"
FT /id="PRO_0000282425"
FT TOPO_DOM 1..27
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..428
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 428 AA; 49024 MW; 1A348DD44643AA4C CRC64;
MARSLCPGAW LRKPYYLQAR FSYVRMKYLF FSWLVVFVGS WIIYVQYSTY TELCRGKDCK
KIICDKYKTG VIDGPACNSL CVTETLYFGK CLSTKPNNQM YLGIWDNLPG VVKCQMEQAL
HLDFGTELEP RKEIVLFDKP TRGTTVQKFK EMVYSLFKAK LGDQGNLSEL VNLILTVADG
DKDGQVSLGE AKSAWALLQL NEFLLMVILQ DKEHTPKLMG FCGDLYVMES VEYTSLYGIS
LPWVIELFIP SGFRRSMDQL FTPSWPRKAK IAIGLLEFVE DVFHGPYGNF LMCDTSAKNL
GYNDKYDLKM VDMRKIVPET NLKELIKDRH CESDLDCVYG TDCRTSCDQS TMKCTSEVIQ
PNLAKACQLL KDYLLRGAPS EIREELEKQL YSCIALKVTA NQMEMEHSLI LNNLKTLLWK
KISYTNDS
//
