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Database: UniProt
Entry: DNAA_GEOKA
LinkDB: DNAA_GEOKA
Original site: DNAA_GEOKA 
ID   DNAA_GEOKA              Reviewed;         450 AA.
AC   Q5L3Z2;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   16-JAN-2019, entry version 84.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=GK0001;
OS   Geobacillus kaustophilus (strain HTA426).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=235909;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTA426;
RX   PubMed=15576355; DOI=10.1093/nar/gkh970;
RA   Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA   Matsui S., Uchiyama I.;
RT   "Thermoadaptation trait revealed by the genome sequence of
RT   thermophilic Geobacillus kaustophilus.";
RL   Nucleic Acids Res. 32:6292-6303(2004).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; BA000043; BAD74286.1; -; Genomic_DNA.
DR   RefSeq; WP_011229517.1; NC_006510.1.
DR   ProteinModelPortal; Q5L3Z2; -.
DR   SMR; Q5L3Z2; -.
DR   STRING; 235909.GK0001; -.
DR   PRIDE; Q5L3Z2; -.
DR   EnsemblBacteria; BAD74286; BAD74286; GK0001.
DR   GeneID; 32065377; -.
DR   KEGG; gka:GK0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000001172; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    450       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114181.
FT   NP_BIND     153    160       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   450 AA;  51611 MW;  D5B71AA9FD37E900 CRC64;
     MENIHDLWDR VLAEIEQKIS KPSFETWLKS TKAHSLRGDT LVIVAPNEFA RDWLDSRYSH
     LIAETIYTIT GEELAVKFII PPNQDDEELE FQSSKKKQRK PYEETNDFPQ SMLNPKYTFD
     TFVIGSGNRF AHAASLAVAE APAKAYNPLF IYGGVGLGKT HLMHAIGHYV IEHNPSAKVV
     YLSSEKFTNE FINAIRDNRP DDFRNKYRNV DVLLIDDIQF LAGKEQTQEE FFHTFNTLHE
     ESKQIVISSD RPPKEIPTLE DRLRSRFEWG LITDITPPDL ETRIAILRKK AKAEGFDIPN
     EVMLYIANQI DSNIRELEGA LIRVVAYSSL INKEITADLA AEALKDIIPS AKPKVITIQD
     IQRVVGQHFN IKMEDFKAKK RTKSVAFPRQ IAMYLSRELT DCSLPKIGDE FGGRDHTTVI
     HAHEKISKLL QTDTQLQRHI QEIQEKLKQL
//
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