GenomeNet

Database: UniProt
Entry: DNAA_GEOSL
LinkDB: DNAA_GEOSL
Original site: DNAA_GEOSL 
ID   DNAA_GEOSL              Reviewed;         445 AA.
AC   Q74GG6;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   16-JAN-2019, entry version 88.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=GSU0000.1;
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA;
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S.,
RA   Gwinn M.L., Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J.,
RA   Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A.,
RA   Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R.,
RA   Van Aken S.E., Lovley D.R., Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AE017180; AAR99581.1; -; Genomic_DNA.
DR   RefSeq; WP_010940678.1; NC_002939.5.
DR   RefSeq; YP_016331.1; NC_002939.5.
DR   ProteinModelPortal; Q74GG6; -.
DR   SMR; Q74GG6; -.
DR   STRING; 243231.GSU0000.1; -.
DR   EnsemblBacteria; AAR99581; AAR99581; GSU0000.1.
DR   GeneID; 2808007; -.
DR   KEGG; gsu:GSU0000.1; -.
DR   PATRIC; fig|243231.5.peg.1; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   InParanoid; Q74GG6; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   BioCyc; GSUL243231:G1G0I-1-MONOMER; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    445       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114182.
FT   NP_BIND     150    157       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   445 AA;  50191 MW;  EAEC2DD5E60414B4 CRC64;
     MEEVWLQAQS NLAKVLTHQT FNTWIEPIKY LGSKKNVLLL EAPNQFVRDR VSESYLPMIL
     ESVQSLTDSQ TKIELLIAKP KTEKPKQPAA SEVTAAEPEA CSGPDHSTNL NPKYTFDTFV
     CGGSNQFAHA AAQSVANSPA GKYNPLFIYG GVGLGKTHLL NAIGNHVLSV NRKARICFYT
     SEKFMNELIN CLRYQKMDQF RNKFRKMDIL LIDDIQFIAG KERTQEEFFH TFNSLYESHK
     QIVVTSDKFP KDIPGLEERL RSRFEWGLIA DIQAPDTETK VAILRKKADA DHISLPDDVA
     LFLASSSTTN VRELEGMLIR LGAVSSLTGK NITLDMAREV LKDIIVDKSK EITVEMIQKF
     VAEHFSLKVA DLKSDKRLKA LVIPRQIAIF LCRDLTKSSY PEIGERFGGK DHSTIIHSVK
     KVEKLLSQDF ELRNTVDTLR KGLLS
//
DBGET integrated database retrieval system