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Database: UniProt
Entry: DNAA_LAWIP
LinkDB: DNAA_LAWIP
Original site: DNAA_LAWIP 
ID   DNAA_LAWIP              Reviewed;         478 AA.
AC   Q1MSG8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   16-JAN-2019, entry version 81.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=LI0001;
OS   Lawsonia intracellularis (strain PHE/MN1-00).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Lawsonia.
OX   NCBI_TaxID=363253;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PHE/MN1-00;
RA   Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L.,
RA   Peterson A., May B., Singh S., Gebhart C., Kapur V.;
RT   "The complete genome sequence of Lawsonia intracellularis: the
RT   causative agent of proliferative enteropathy.";
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AM180252; CAJ54057.1; -; Genomic_DNA.
DR   RefSeq; WP_011526084.1; NC_008011.1.
DR   ProteinModelPortal; Q1MSG8; -.
DR   SMR; Q1MSG8; -.
DR   STRING; 363253.LI0001; -.
DR   PRIDE; Q1MSG8; -.
DR   KEGG; lip:LI0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; 219876at2; -.
DR   BioCyc; LINT363253:G1GJC-1-MONOMER; -.
DR   Proteomes; UP000002430; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    478       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000121993.
FT   NP_BIND     177    184       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   478 AA;  53685 MW;  C134113B5F0AEDA6 CRC64;
     MSYMNTTWEK VCDSLQKRLS PGTFKVWIAP LVASEHDGQL FLYAPSLFVM NWIQERLFVD
     ITEAVSEVSG GTMKVQIEVK SSVPDKPQVS LTDYNNKQHI PYNGFPNTKV SISRSHISSQ
     TEQLPLPVSL VKAPFSSRSW RYSFDSFVVG PCNNLAHAAA QNMIKDTASV DTLFLSSGPG
     LGKTHLTQAV GQALCNISNR ANPKVEYLTA EEFCSCFVQS LRTKNVDSFK GRFRDTDLFL
     LEDIHFLQGK EKMQDELLAT IRSLQGRGSR VVLTSSFAPK ELKNVDNRLV SRFCSGFLAG
     IEKPNAETRR RILIEKAKVH AVVLSEAVAD FLAMKLVGDI RQLESSISNL VLKAKLLDCM
     ISMDMAKDVI AQYTQDDPFM NIDSIIHAVS GSFGLQAEKL YSRSRKQDFV VARNTIFYLA
     RKHTDMSLQE IGDRFHRRHS TVLKGIASIE REIQRKSPTG RQIANTLNLL ERTNIHLN
//
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