ID DPB4_DEBHA Reviewed; 247 AA.
AC Q6BIP4;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 24-JAN-2024, entry version 100.
DE RecName: Full=DNA polymerase epsilon subunit D;
DE AltName: Full=DNA polymerase II subunit D;
GN Name=DPB4; OrderedLocusNames=DEHA2G08756g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: As accessory component of the DNA polymerase epsilon (DNA
CC polymerase II) participates in chromosomal DNA replication.
CC {ECO:0000250|UniProtKB:Q04603}.
CC -!- SUBUNIT: Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3
CC and DPB4 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC beta, gamma, delta, and epsilon which are responsible for different
CC reactions of DNA synthesis.
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DR EMBL; CR382139; CAG90392.2; -; Genomic_DNA.
DR RefSeq; XP_461927.2; XM_461927.1.
DR AlphaFoldDB; Q6BIP4; -.
DR SMR; Q6BIP4; -.
DR STRING; 284592.Q6BIP4; -.
DR GeneID; 2904813; -.
DR KEGG; dha:DEHA2G08756g; -.
DR VEuPathDB; FungiDB:DEHA2G08756g; -.
DR eggNOG; KOG0870; Eukaryota.
DR HOGENOM; CLU_087036_0_0_1; -.
DR InParanoid; Q6BIP4; -.
DR OMA; NTYRRKV; -.
DR OrthoDB; 1384627at2759; -.
DR Proteomes; UP000000599; Chromosome G.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR PANTHER; PTHR46172; DNA POLYMERASE EPSILON SUBUNIT 3; 1.
DR PANTHER; PTHR46172:SF1; DNA POLYMERASE EPSILON SUBUNIT 3; 1.
DR Pfam; PF00125; Histone; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..247
FT /note="DNA polymerase epsilon subunit D"
FT /id="PRO_0000191750"
FT REGION 128..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..184
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..213
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..247
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 247 AA; 27698 MW; 5E89FFD8EEEAA041 CRC64;
MPPKGWRKNT EGQYPQPNKD QDLVSIDEIL FPRATVQKLA KNIMNASSDE GASNMILAKD
SMIALQRSST VFVSHLMFQA RQISKDEGRK TINAQDILSA LEKAEFSGFI PEVKQKLSVF
ESNIALRKKH KADKKVPKPE GVDASPSSKR LKDNDEQIIQ RDNSADMEDD PEAEADEDIT
EELANDEDTN NKESKEEEEA DEELDDEKDG EEVEENPIAL LSREEDELRG EEAADEDEGQ
NSSDDDS
//
