ID DPOL_ABVP Reviewed; 653 AA.
AC A4ZU91; A4ZU92;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 13-SEP-2023, entry version 69.
DE RecName: Full=DNA polymerase;
DE EC=2.7.7.7;
GN ORFNames=ORF653;
OS Acidianus bottle-shaped virus (isolate Italy/Pozzuoli) (ABV).
OC Viruses; Ampullaviridae; Bottigliavirus; Bottigliavirus ABV.
OX NCBI_TaxID=654911;
OH NCBI_TaxID=269667; Acidianus convivator.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17412384; DOI=10.1016/j.virol.2007.03.005;
RA Peng X., Basta T., Haring M., Garrett R.A., Prangishvili D.;
RT "Genome of the Acidianus bottle-shaped virus and insights into the
RT replication and packaging mechanisms.";
RL Virology 364:237-243(2007).
CC -!- FUNCTION: Replicates viral genomic DNA. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=DNA polymerase;
CC IsoId=A4ZU91-1; Sequence=Displayed;
CC Name=ORF462;
CC IsoId=A4ZU91-2; Sequence=VSP_038084;
CC -!- MISCELLANEOUS: [Isoform ORF462]: Produced by alternative initiation of
CC the DNA polymerase mRNA. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABP73395.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; EF432053; ABP73396.1; -; Genomic_DNA.
DR EMBL; EF432053; ABP73395.1; ALT_INIT; Genomic_DNA.
DR RefSeq; YP_001210309.1; NC_009452.1.
DR RefSeq; YP_001210310.1; NC_009452.1.
DR GeneID; 5129850; -.
DR GeneID; 5129855; -.
DR KEGG; vg:5129850; -.
DR KEGG; vg:5129855; -.
DR Proteomes; UP000000513; Segment.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR Pfam; PF03175; DNA_pol_B_2; 1.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Alternative initiation; DNA replication; DNA-binding;
KW DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transferase; Viral DNA replication.
FT CHAIN 1..653
FT /note="DNA polymerase"
FT /id="PRO_0000384817"
FT VAR_SEQ 1..191
FT /note="Missing (in isoform ORF462)"
FT /evidence="ECO:0000305"
FT /id="VSP_038084"
SQ SEQUENCE 653 AA; 76864 MW; 54170AF0C026F0A7 CRC64;
MLQILNNAND KIQYKLNDFS DLTPSFKIKS GFFTIHRINY EKLEENEEEK PRQISAFDIE
TNGREIFFGV YDGSEYKYVI IRKPEDVKNA LDLLTEETYF YGDYDLPVSL ANYVLLGKHS
KFAKKITGEN YFTTKNLRIK RYKNFYKILY NGRSINSINL LQFYSESLYE AYSRYYTKLQ
EMGFQVFDEQ TMKEWKEDKE KRANFDKLDF NDPKTIQEIA RYNKLDVIAT YQLALLKNSL
FGIKVKSTLP RTAITYIISQ VQSEFVKGLR SYTEIELTLK RLYKGGLFDS NELGKFKKVY
KYDVNSMYPF MMSWLPELEL VETQKGFEVN EEPLLKGTQF NEDAKYVYIY KITLKQDRKY
VASKANGMLL RMMYNRGSFF DFELADEKHE LIPDIKIVGQ YYTMKFKITK HRIFKDVIYN
LYNKRLQLKK EKNPLEKVYK LILNSSYGKF GERIGFNAKF QNVIYASMIT ALGRTFIQNV
DPNAISYLTD SVISKAPIKS ELVGDQLGQL KQEGVGEAIV IGNGQYILND PQEKMIKLRG
FNVDESIAEK IIEYVGNYLA KGKIVRVQIP TKIMIRNLQQ YKILAEKDSN VLMGMLSNQI
KIFTPLNTKQ RYTYNVHWFG SMFRDEQEHK EYRKTWEKYI ETIEPIDLNS ILS
//
