ID DRAM2_BOVIN Reviewed; 266 AA.
AC Q3ZC48;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 102.
DE RecName: Full=DNA damage-regulated autophagy modulator protein 2;
DE AltName: Full=Transmembrane protein 77;
GN Name=DRAM2; Synonyms=TMEM77;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the initiation of autophagy. In the retina,
CC might be involved in the process of photoreceptor cells renewal and
CC recycling to preserve visual function. Induces apoptotic cell death
CC when coexpressed with DRAM1. {ECO:0000250|UniProtKB:Q6UX65}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q6UX65};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6UX65}.
CC Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9CR48}. Apical cell
CC membrane {ECO:0000250|UniProtKB:Q9CR48}. Note=Localized to
CC photoreceptor inner segments and to the apical surface of retinal
CC pigment epithelial cells. {ECO:0000250|UniProtKB:Q9CR48}.
CC -!- SIMILARITY: Belongs to the DRAM/TMEM150 family. {ECO:0000305}.
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DR EMBL; BC102918; AAI02919.1; -; mRNA.
DR RefSeq; NP_001070464.1; NM_001076996.2.
DR RefSeq; XP_010801534.1; XM_010803232.2.
DR RefSeq; XP_015319466.1; XM_015463980.1.
DR AlphaFoldDB; Q3ZC48; -.
DR SMR; Q3ZC48; -.
DR STRING; 9913.ENSBTAP00000071255; -.
DR PaxDb; 9913-ENSBTAP00000013037; -.
DR Ensembl; ENSBTAT00000013037.4; ENSBTAP00000013037.3; ENSBTAG00000009888.6.
DR Ensembl; ENSBTAT00000070934.1; ENSBTAP00000071255.1; ENSBTAG00000009888.6.
DR GeneID; 767922; -.
DR KEGG; bta:767922; -.
DR CTD; 128338; -.
DR VEuPathDB; HostDB:ENSBTAG00000009888; -.
DR VGNC; VGNC:28202; DRAM2.
DR eggNOG; KOG4320; Eukaryota.
DR GeneTree; ENSGT01030000234578; -.
DR HOGENOM; CLU_059992_2_2_1; -.
DR InParanoid; Q3ZC48; -.
DR OMA; CVYIRHR; -.
DR OrthoDB; 2896974at2759; -.
DR TreeFam; TF314508; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000009888; Expressed in conceptus and 109 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR GO; GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0045494; P:photoreceptor cell maintenance; ISS:UniProtKB.
DR GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; ISS:UniProtKB.
DR InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR PANTHER; PTHR21324:SF10; DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 2; 1.
DR PANTHER; PTHR21324; FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED; 1.
DR Pfam; PF10277; Frag1; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Autophagy; Cell membrane; Lysosome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..266
FT /note="DNA damage-regulated autophagy modulator protein 2"
FT /id="PRO_0000254101"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 266 AA; 29923 MW; A3A00ECE27834855 CRC64;
MWWFQQGLSF LPSALVIWTA AAFIFSYITA ITLHHVDPVL PYISDTGTVA PEKCLFGAML
NIAAVLCVAT IYVRYKQVHA LNPEENRIIR LNKAGLVLGL LSCLGLSLVA NFQKTTFFAV
HVCGAVLTFG MGSLYMFVQT ILSYQMQPKI HGKQVFWIRL LLVIWCGVSA FSMLTCSSLL
YNGSFGADIV QKLHWNPEDK GYVLHMITTA AEWSMSLSFF GFFLTYIRDF QKISLRVEAT
LHGLTLYDTA PCPVNNERTW LLSRDV
//
