ID DRGX_RAT Reviewed; 263 AA.
AC Q62798;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 08-NOV-2023, entry version 137.
DE RecName: Full=Dorsal root ganglia homeobox protein;
DE AltName: Full=Dorsal root ganglion 11;
DE AltName: Full=Homeobox protein DRG11;
DE AltName: Full=Paired-related homeobox protein-like 1;
GN Name=Drgx; Synonyms=Drg11, Prrxl1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Spinal ganglion;
RX PubMed=7496632; DOI=10.1006/mcne.1995.1022;
RA Saito T., Greenwood A., Sun Q., Anderson D.J.;
RT "Identification by differential RT-PCR of a novel paired homeodomain
RT protein specifically expressed in sensory neurons and a subset of their CNS
RT targets.";
RL Mol. Cell. Neurosci. 6:280-292(1995).
CC -!- FUNCTION: Transcription factor required for the formation of correct
CC projections from nociceptive sensory neurons to the dorsal horn of the
CC spinal cord and normal perception of pain. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RGMB. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00138}.
CC -!- TISSUE SPECIFICITY: Expressed in most sensory neurons but not in
CC autonomic neurons. Also expressed in the dorsal horn of the spinal
CC cord.
CC -!- DEVELOPMENTAL STAGE: First detected at 12.5 dpc in the nervous system
CC and in the dorsal root ganglia of the trunk region. By 15.5 dpc, strong
CC expression in trunk and dorsal spinal cord and at 17.5 dpc expression
CC increases in the dorsal horns.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; U29174; AAA87203.1; -; mRNA.
DR RefSeq; NP_665710.1; NM_145767.1.
DR AlphaFoldDB; Q62798; -.
DR SMR; Q62798; -.
DR IntAct; Q62798; 1.
DR STRING; 10116.ENSRNOP00000027186; -.
DR PhosphoSitePlus; Q62798; -.
DR PaxDb; 10116-ENSRNOP00000027186; -.
DR GeneID; 252880; -.
DR KEGG; rno:252880; -.
DR UCSC; RGD:628616; rat.
DR AGR; RGD:628616; -.
DR CTD; 644168; -.
DR RGD; 628616; Drgx.
DR eggNOG; KOG0490; Eukaryota.
DR InParanoid; Q62798; -.
DR OrthoDB; 2901226at2759; -.
DR PhylomeDB; Q62798; -.
DR PRO; PR:Q62798; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0007411; P:axon guidance; ISO:RGD.
DR GO; GO:0007409; P:axonogenesis; ISO:RGD.
DR GO; GO:0009593; P:detection of chemical stimulus; ISO:RGD.
DR GO; GO:0016048; P:detection of temperature stimulus; ISO:RGD.
DR GO; GO:0021516; P:dorsal spinal cord development; ISO:RGD.
DR GO; GO:0007399; P:nervous system development; ISO:RGD.
DR GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR GO; GO:0001764; P:neuron migration; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0050954; P:sensory perception of mechanical stimulus; ISO:RGD.
DR GO; GO:0021559; P:trigeminal nerve development; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR24329:SF542; DORSAL ROOT GANGLIA HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..263
FT /note="Dorsal root ganglia homeobox protein"
FT /id="PRO_0000049258"
FT DNA_BIND 33..92
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 88..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 204..217
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT COMPBIAS 222..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 263 AA; 28621 MW; 195DBB44D5953D6F CRC64;
MFYFHCPPQL EGTAPFGNHS TGDFDDGFLR RKQRRNRTTF ALQQLEALEA VFAQTHYPDV
FTREELAMKI NLTEARVQVW FQNRRAKWRK TERGASDQEP GAKEPMAEVT PPPVRNINSP
PPGDQARGKK EALEAQQSLG RTVGPAGPFF PSCLPGTLLN TATYAQALSH VASLKGGPLC
SCCVPDPMGL SFLPTYGCQS NRTASVAALR MKAREHSEAV LQSANLLPST SSSPGPASKQ
VPPEGSQDKP SPTKEQSEGE KSV
//
