ID DRL27_ARATH Reviewed; 985 AA.
AC Q9T048; Q1PE47;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 141.
DE RecName: Full=Disease resistance protein At4g27190;
GN OrderedLocusNames=At4g27190; ORFNames=T24A18.140;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
CC -!- FUNCTION: Disease resistance protein. {ECO:0000250}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AL035680; CAB38849.1; -; Genomic_DNA.
DR EMBL; AL161566; CAB79574.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85311.1; -; Genomic_DNA.
DR EMBL; DQ446871; ABE66092.1; -; mRNA.
DR PIR; T06049; T06049.
DR RefSeq; NP_194449.1; NM_118853.2.
DR AlphaFoldDB; Q9T048; -.
DR SMR; Q9T048; -.
DR STRING; 3702.Q9T048; -.
DR PaxDb; 3702-AT4G27190-1; -.
DR EnsemblPlants; AT4G27190.1; AT4G27190.1; AT4G27190.
DR GeneID; 828827; -.
DR Gramene; AT4G27190.1; AT4G27190.1; AT4G27190.
DR KEGG; ath:AT4G27190; -.
DR Araport; AT4G27190; -.
DR TAIR; AT4G27190; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000427_2_0_1; -.
DR InParanoid; Q9T048; -.
DR OMA; SSQDDCH; -.
DR OrthoDB; 3950708at2759; -.
DR PhylomeDB; Q9T048; -.
DR PRO; PR:Q9T048; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9T048; baseline and differential.
DR Genevisible; Q9T048; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR33463:SF189; NB-ARC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR33463; NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51450; LRR; 6.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..985
FT /note="Disease resistance protein At4g27190"
FT /id="PRO_0000212759"
FT DOMAIN 167..429
FT /note="NB-ARC"
FT REPEAT 502..523
FT /note="LRR 1"
FT REPEAT 526..547
FT /note="LRR 2"
FT REPEAT 551..572
FT /note="LRR 3"
FT REPEAT 575..597
FT /note="LRR 4"
FT REPEAT 598..620
FT /note="LRR 5"
FT REPEAT 621..643
FT /note="LRR 6"
FT COILED 24..88
FT /evidence="ECO:0000255"
FT BINDING 171..178
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 985 AA; 112947 MW; 0ABA3B49A21FB93E CRC64;
MECCAPVIGE ILRLMYESTF SRVANAIKFK SNVKALNESL ERLTELKGNM SEDHETLLTK
DKPLRLKLMR WQREAEEVIS KARLKLEERV SCGMSLRPRM SRKLVKILDE VKMLEKDGIE
FVDMLSVEST PERVEHVPGV SVVHQTMASN MLAKIRDGLT SEKAQKIGVW GMGGVGKTTL
VRTLNNKLRE EGATQPFGLV IFVIVSKEFD PREVQKQIAE RLDIDTQMEE SEEKLARRIY
VGLMKERKFL LILDDVWKPI DLDLLGIPRT EENKGSKVIL TSRFLEVCRS MKTDLDVRVD
CLLEEDAWEL FCKNAGDVVR SDHVRKIAKA VSQECGGLPL AIITVGTAMR GKKNVKLWNH
VLSKLSKSVP WIKSIEEKIF QPLKLSYDFL EDKAKFCFLL CALFPEDYSI EVTEVVRYWM
AEGFMEELGS QEDSMNEGIT TVESLKDYCL LEDGDRRDTV KMHDVVRDFA IWIMSSSQDD
SHSLVMSGTG LQDIRQDKLA PSLRRVSLMN NKLESLPDLV EEFCVKTSVL LLQGNFLLKE
VPIGFLQAFP TLRILNLSGT RIKSFPSCSL LRLFSLHSLF LRDCFKLVKL PSLETLAKLE
LLDLCGTHIL EFPRGLEELK RFRHLDLSRT LHLESIPARV VSRLSSLETL DMTSSHYRWS
VQGETQKGQA TVEEIGCLQR LQVLSIRLHS SPFLLNKRNT WIKRLKKFQL VVGSRYILRT
RHDKRRLTIS HLNVSQVSIG WLLAYTTSLA LNHCQGIEAM MKKLVSDNKG FKNLKSLTIE
NVIINTNSWV EMVSTNTSKQ SSDILDLLPN LEELHLRRVD LETFSELQTH LGLKLETLKI
IEITMCRKLR TLLDKRNFLT IPNLEEIEIS YCDSLQNLHE ALLYHQPFVP NLRVLKLRNL
PNLVSICNWG EVWECLEQVE VIHCNQLNCL PISSTCGRIK KIKGELSWWE RLEWDDPSAL
TTVQPFFNPV REVPLLIADA TTQML
//
