ID DRL44_ARATH Reviewed; 1017 AA.
AC P0DI16; Q8W3J8; Q8W3J9; Q94HW5; Q9SLU5; Q9SLU6;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Probable disease resistance protein RDL5;
GN Name=RDL5; OrderedLocusNames=At1g59124; ORFNames=T4M14.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=10548732; DOI=10.1016/s0378-1119(99)00403-5;
RA Kato A., Suzuki M., Kuwahara A., Ooe H., Higano-Inaba K., Komeda Y.;
RT "Isolation and analysis of cDNA within a 300 kb Arabidopsis thaliana
RT genomic region located around the 100 map unit of chromosome 1.";
RL Gene 239:309-316(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Potential disease resistance protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P0DI16-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P0DI16-2; Sequence=VSP_043691, VSP_043692;
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK62797.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AB078516; BAB84017.1; -; Genomic_DNA.
DR EMBL; AC027036; AAK62797.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33570.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60642.1; -; Genomic_DNA.
DR RefSeq; NP_001117515.1; NM_001124043.2. [P0DI16-2]
DR RefSeq; NP_001322914.1; NM_001333846.1. [P0DI16-1]
DR RefSeq; NP_176151.2; NM_104635.3. [P0DI16-2]
DR RefSeq; NP_683446.1; NM_148605.4. [P0DI16-1]
DR AlphaFoldDB; P0DI16; -.
DR SMR; P0DI16; -.
DR STRING; 3702.P0DI16; -.
DR EnsemblPlants; AT1G58807.1; AT1G58807.1; AT1G58807. [P0DI16-1]
DR EnsemblPlants; AT1G58807.2; AT1G58807.2; AT1G58807.
DR EnsemblPlants; AT1G59124.1; AT1G59124.1; AT1G59124.
DR EnsemblPlants; AT1G59124.2; AT1G59124.2; AT1G59124. [P0DI16-1]
DR GeneID; 842225; -.
DR GeneID; 842232; -.
DR Gramene; AT1G58807.1; AT1G58807.1; AT1G58807. [P0DI16-1]
DR Gramene; AT1G58807.2; AT1G58807.2; AT1G58807.
DR Gramene; AT1G59124.1; AT1G59124.1; AT1G59124.
DR Gramene; AT1G59124.2; AT1G59124.2; AT1G59124. [P0DI16-1]
DR KEGG; ath:AT1G58807; -.
DR KEGG; ath:AT1G59124; -.
DR Araport; AT1G59124; -.
DR TAIR; AT1G59124; -.
DR HOGENOM; CLU_000837_35_5_1; -.
DR InParanoid; P0DI16; -.
DR OMA; RVINWCI; -.
DR OrthoDB; 677213at2759; -.
DR PRO; PR:P0DI16; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; P0DI16; baseline and differential.
DR Genevisible; P0DI16; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0098542; P:defense response to other organism; IBA:GO_Central.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1185; DISEASE RESISTANCE RPP8-LIKE PROTEIN 3-RELATED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ATP-binding; Coiled coil; Leucine-rich repeat;
KW Nucleotide-binding; Plant defense; Reference proteome; Repeat.
FT CHAIN 1..1017
FT /note="Probable disease resistance protein RDL5"
FT /id="PRO_0000417428"
FT DOMAIN 147..460
FT /note="NB-ARC"
FT REPEAT 602..627
FT /note="LRR 1"
FT REPEAT 649..674
FT /note="LRR 2"
FT REPEAT 675..699
FT /note="LRR 3"
FT REPEAT 768..791
FT /note="LRR 4"
FT REPEAT 792..819
FT /note="LRR 5"
FT REPEAT 841..865
FT /note="LRR 6"
FT REPEAT 937..962
FT /note="LRR 7"
FT COILED 25..52
FT /evidence="ECO:0000255"
FT BINDING 190..197
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 851..855
FT /note="VCRKL -> IHCRL (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_043691"
FT VAR_SEQ 856..1017
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_043692"
SQ SEQUENCE 1017 AA; 117047 MW; 8CC2F618D5DACBB4 CRC64;
MAGELISFGI QNLWNLLSQE CELFQGVEDQ VTELKRDLNM LSSFLKDANA KKHTSAVVKN
CVEEIKEIIY DGEDTIETFV LEQNLGKTSG IKKSIRRLAC IIPDRRRYAL GIGGLSNRIS
KVIRDMQSFG VQQAIVDGGY KQPQGDKQRE MRQKFSKDDD SDFVGLEANV KKLVGYLVDE
ANVQVVSITG MGGLGKTTLA KQVFNHEDVK HQFDGLSWVC VSQDFTRMNV WQKILRDLKP
KEEEKKIMEM TQDTLQGELI RLLETSKSLI VLDDIWEKED WELIKPIFPP TKGWKVLLTS
RNESVAMRRN TSYINFKPEC LTTEDSWTLF QRIALPMKDA AEFKIDEEKE ELGKLMIKHC
GGLPLAIRVL GGMLAEKYTS HDWRRLSENI GSHLVGGRTN FNDDNNNTCN NVLSLSFEEL
PSYLKHCFLY LAHFPEDYEI KVENLSYYWA AEGIFQPRHY DGETIRDVGD VYIEELVRRN
MVISERDVKT SRFETCHLHD MMREVCLLKA KEENFLQITS SRPSTANLQS TVTSRRFVYQ
YPTTLHVEKD INNPKLRALV VVTLGSWNLA GSSFTRLELL RVLDLIEVKI KGGKLASCIG
KLIHLRYLSL EYAEVTHIPY SLGNLKLLIY LNLASFGRST FVPNVLMGMQ ELRYLALPSD
MGRKTKLELS NLVKLETLEN FSTENSSLED LCGMVRLSTL NIKLIEETSL ETLAASIGGL
KYLEKLEIYD HGSEMRTKEA GIVFDFVHLK RLWLKLYMPR LSTEQHFPSH LTTLYLESCR
LEEDPMPILE KLLQLKELEL GFESFSGKKM VCSSGGFPQL QRLSLLKLEE WEDWKVEESS
MPLLRTLDIQ VCRKLKQLPD EHLPSHLTSI SLFFCCLEKD PLPTLGRLVY LKELQLGFRT
FSGRIMVCSG GGFPQLQKLS IYRLEEWEEW IVEQGSMPFL HTLYIDDCPK LKKLPDGLQF
IYSLKNLKIS ERWKERLSEG GEEYYKVQHI PSVEFYHRVL HIFRSVGGDI TGRLLMR
//
