ID DZAN1_MACFA Reviewed; 777 AA.
AC Q9GKS9; A0A2K5WVL3;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2023, sequence version 3.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Double zinc ribbon and ankyrin repeat-containing protein 1;
GN Name=DZANK1; ORFNames=QccE-20932;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain cortex;
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA Suzuki Y., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in vesicle transport in photoreceptor cells.
CC {ECO:0000250|UniProtKB:Q1LXR6}.
CC -!- SUBUNIT: Interacts with NINL. Associates with DYNC1H1 and multiple
CC dynein intermediate and light chains as well as actin-binding proteins.
CC {ECO:0000250|UniProtKB:Q9NVP4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q9NVP4}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9NVP4}.
CC Note=Colocalizes with NINL at the base of cilia.
CC {ECO:0000250|UniProtKB:Q9NVP4}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9GKS9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9GKS9-2; Sequence=VSP_062031;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB19005.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB052150; BAB19005.1; ALT_FRAME; mRNA.
DR EMBL; AQIA01008038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01008039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01008040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01008041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q9GKS9; -.
DR STRING; 9541.ENSMFAP00000041073; -.
DR Ensembl; ENSMFAT00000015346.2; ENSMFAP00000041073.2; ENSMFAG00000041179.2. [Q9GKS9-1]
DR VEuPathDB; HostDB:ENSMFAG00000041179; -.
DR eggNOG; ENOG502QTJR; Eukaryota.
DR GeneTree; ENSGT00390000000549; -.
DR OrthoDB; 2940197at2759; -.
DR Proteomes; UP000233100; Chromosome 10.
DR Bgee; ENSMFAG00000041179; Expressed in temporal lobe and 9 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042462; P:eye photoreceptor cell development; ISS:UniProtKB.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR025874; DZR.
DR InterPro; IPR026876; Fn3_assoc_repeat.
DR PANTHER; PTHR16058; DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR16058:SF4; DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF12773; DZR; 1.
DR Pfam; PF13287; Fn3_assoc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Cell projection; Cytoplasm; Cytoskeleton;
KW Metal-binding; Phosphoprotein; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..777
FT /note="Double zinc ribbon and ankyrin repeat-containing
FT protein 1"
FT /id="PRO_0000066987"
FT REPEAT 442..473
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 477..506
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT ZN_FING 230..289
FT /note="DZANK-type 1"
FT ZN_FING 358..406
FT /note="DZANK-type 2"
FT REGION 161..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 201
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVP4"
FT VAR_SEQ 1..199
FT /note="MTAGSVCVPQIIPLRVPQPGKANHEIDNNTLLEMKSDTPDVNIYYTLDGSKP
FT EFLKRTGYVENNTFKYTKPITLPDGKIQVKAIAVSKDCRQSGIVTKVFQVGYEPPNVVS
FT PEDNVENVLKDSSRQEFKNGLVGSKLKKKYQNSENQRSWNVNLRKFPDLQVGERTDPKT
FT LKDLRFSESPLEIPAHSGGSGSRPPTRQS -> MLTSESFQRVHWKSQLTVEDQVLDHP
FT PA (in isoform 2)"
FT /id="VSP_062031"
FT CONFLICT 237
FT /note="R -> C (in Ref. 1; BAB19005)"
FT /evidence="ECO:0000305"
FT CONFLICT 348
FT /note="L -> P (in Ref. 1; BAB19005)"
FT /evidence="ECO:0000305"
FT CONFLICT 586
FT /note="G -> E (in Ref. 1; BAB19005)"
FT /evidence="ECO:0000305"
FT CONFLICT 718
FT /note="I -> V (in Ref. 1; BAB19005)"
FT /evidence="ECO:0000305"
FT CONFLICT 728
FT /note="I -> V (in Ref. 1; BAB19005)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 777 AA; 85066 MW; ACB0DC938D0C23EE CRC64;
MTAGSVCVPQ IIPLRVPQPG KANHEIDNNT LLEMKSDTPD VNIYYTLDGS KPEFLKRTGY
VENNTFKYTK PITLPDGKIQ VKAIAVSKDC RQSGIVTKVF QVGYEPPNVV SPEDNVENVL
KDSSRQEFKN GLVGSKLKKK YQNSENQRSW NVNLRKFPDL QVGERTDPKT LKDLRFSESP
LEIPAHSGGS GSRPPTRQSQ SPGFAHISGL KCLTSTEIMR IQRETDFLKC AHCLAPRPSD
PFARFCQECG SPVPPIFGCR LPPPEGAQMG LCAECRSLVP MNTPICVVCE APLALQLQPQ
ASLHLKEKVI CRACGTGNPA HLRYCVTCEG ALPSSQESIC SGDKASPLPT QKGGTISCSR
CGRWNLWEAS FCGWCGAMLG IPAGCSVCPK CGASNHLSAR FCGSCGICVK SLVKLSLDRS
LALAAQEPRP FSEPQCAWQS LNIPLPRSDA GTKRDIGTQT VGLFYPSGKL LAKKELEIAS
QKQRQEKMSD HKPLLTAISP GRGYWRRQLD HISAHLRCYA QNNPEFRALI AEPRMGKLIS
ATVHEDGCEV SIRLNYSQVS NKNLYLNKAV NFSDHLLSSA AEGDGGLCGS RSSWVSDYSQ
STSDTIEKIK RIRNFKTKTF QEKEEQLLPE NRLLLKEVGP TGEGRVSVIE QLLDEGADPN
CCDEDNRPVI TVAVMNKHHE AIPVLVQRGA DIDQQWGPLR NTALHEATLL GFAGRESIAT
LLGCNASIRK KNAGGQTAYD LALNTGDDLI TSLFAAKFGQ GLEDQLAQTR SLRLDDC
//