ID E0AHC1_CAEEL Unreviewed; 429 AA.
AC E0AHC1;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0000313|EMBL:CBW44390.1};
GN Name=nmr-2 {ECO:0000313|EMBL:CBW44390.1,
GN ECO:0000313|WormBase:T01C3.10b};
GN ORFNames=CELE_T01C3.10 {ECO:0000313|EMBL:CBW44390.1}, T01C3.10
GN {ECO:0000313|WormBase:T01C3.10b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CBW44390.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CBW44390.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CBW44390.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; BX284605; CBW44390.1; -; Genomic_DNA.
DR RefSeq; NP_001256641.1; NM_001269712.1.
DR AlphaFoldDB; E0AHC1; -.
DR SMR; E0AHC1; -.
DR EnsemblMetazoa; T01C3.10b.1; T01C3.10b.1; WBGene00003775.
DR GeneID; 180002; -.
DR AGR; WB:WBGene00003775; -.
DR WormBase; T01C3.10b; CE45268; WBGene00003775; nmr-2.
DR HOGENOM; CLU_002039_3_0_1; -.
DR OrthoDB; 1034721at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003775; Expressed in larva and 1 other cell type or tissue.
DR ExpressionAtlas; E0AHC1; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0004972; F:NMDA glutamate receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0035249; P:synaptic transmission, glutamatergic; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF391; NMDA RECEPTOR 2, ISOFORM C; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:CBW44390.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..295
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT REGION 382..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 429 AA; 48863 MW; 708E02BA2D75D02C CRC64;
MHNKADMCVT SLKLNSERAR DIDFSLPFLD TGISIIVKIR SGVLSPTAFL EPFEYSTWVI
ILFVCIHVAA ISIFLFEWVS PYSFNMQKYP PPEHKFSLFR SYWLVWATLF SASVSTDVPK
STVSRLMALV WAAFGLTFLA VYTANLAAFM ITRVQYYDLS GIHDPMLNFP HDQKPPFRFG
TVDGGNTHET MKRNWHKMHE YVKHNKYFRM NISAGIEAVK NEELDAFIYD AVVLDYWAGK
DANCALMTVG KWASMTGYGI GFPKNSPHTS LVNHYMLQYQ QKGDLERLQN FWLTGACTPD
SHSQTQSAPL GIENFLSAFV LLAGGIIVSV IVLGFEHIYC MHLRKPLQKI DPNGWCGIIS
MAMGKSLTFT EAVDRVQEWR SRTQSLASTN SPQLKRRRSA NLRPTEEPFN QDLNPPRRSP
RFLQVETNL
//