ID E0CYZ3_MOUSE Unreviewed; 1901 AA.
AC E0CYZ3;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Calcium channel, voltage-dependent, T type, alpha 1H subunit {ECO:0000313|Ensembl:ENSMUSP00000123741.2};
GN Name=Cacna1h {ECO:0000313|Ensembl:ENSMUSP00000123741.2,
GN ECO:0000313|MGI:MGI:1928842};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123741.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000123741.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123741.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000123741.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123741.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; E0CYZ3; -.
DR SwissPalm; E0CYZ3; -.
DR MaxQB; E0CYZ3; -.
DR ProteomicsDB; 309954; -.
DR Antibodypedia; 22964; 340 antibodies from 32 providers.
DR Ensembl; ENSMUST00000159048.8; ENSMUSP00000123741.2; ENSMUSG00000024112.17.
DR AGR; MGI:1928842; -.
DR MGI; MGI:1928842; Cacna1h.
DR VEuPathDB; HostDB:ENSMUSG00000024112; -.
DR GeneTree; ENSGT00940000156666; -.
DR HOGENOM; CLU_000540_2_0_1; -.
DR ChiTaRS; Cacna1h; mouse.
DR Proteomes; UP000000589; Chromosome 17.
DR Bgee; ENSMUSG00000024112; Expressed in retinal neural layer and 180 other cell types or tissues.
DR ExpressionAtlas; E0CYZ3; baseline and differential.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF192; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|ProteomicsDB:E0CYZ3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 806..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 883..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1238..1259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1271..1297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1335..1357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1436..1460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1516..1535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1547..1568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1651..1671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1738..1759
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..323
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 684..914
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1198..1470
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1516..1769
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 384..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1785..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1868..1901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1469..1496
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 394..429
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1075
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1786..1805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1901 AA; 213295 MW; 7E6E53E197AEA4AC CRC64;
MLVIMLNCVT LGMFRPCEDV ECRSERCSIL EAFDDFIFAF FAVEMVIKMV ALGLFGQKCY
LGDTWNRLDF FIVMAGMMEY SLDGHNVSLS AIRTVRVLRP LRAINRVPSM RILVTLLLDT
LPMLGNVLLL CFFVFFIFGI VGVQLWAGLL RNRCFLDSAF VRNNNLTFLR PYYQTEEGEE
NPFICSSRRD NGMQKCSHIP SRRELRVQCT LGWEAYGQPQ AEDGGAGRNA CINWNQYYNV
CRSGEFNPHN GAINFDNIGY AWIAIFQVIT LEGWVDIMYY VMDAHSFYNF IYFILLIIVG
SFFMINLCLV VIATQFSETK QRENQLMREQ RARYLSNDST LASFSEPGSC YEELLKYVGH
IFRKVKRRSL RLYARWQSRW RKKVDPSSTL HGQGPRRRPR RAGRRTASVH HLVYHHHHHH
HHHYHFSHGG PRRPSPEPGA GDTRLVRACV PPSPPSPGHG PPDSESVHSI YHADCHVEGP
QERARVAHTI ATAASLKLAS GLGTMNYPTI LPSGAVNSKG STSSRPKGLR SAGTPGATAH
SPLSLGSPSP YEKIQHVVGE QGLGRASSHL SGLSVPCPLP SPQAGTLTCE LKSCPYCASA
LEDPEFEFSG SESGDSDAHG VYEFTQDVRH GDCRDPVQQP HEGGTPGHGN ERWRPPLRTA
SQPGGLGRLW ASFSSKLRRI VDSKYFNRGI MAAILVNTLS MGVEYHEQPD ELTNALEISN
IVFTSMFALE MLLKLLACGP LGYIRNPYNI FDGIVVIISV WEIVGQADGG LSVLRTFRLL
RVLKLVRFLP ALRRQLVVLM RTMDNVATFC MLLMLFIFIF SILGMHLFGC KFSLKTDSGD
TVPDRKNFDS LLWAIVTVFQ ILTQEDWNVV LYNGMASTSS WAALYFVALM TFGNYVLFNL
LVAILVEGFQ AEGDATRSDT DEDKTSTHLE EDFDKLRDVQ ATEMKMYSLA VTPNGHLEGR
GSLPPPLITH TAATPMPTPK SSPHLDMAHT LLDSRRSSSG SVDPQLGDQK SLASLRSSPC
APWGPNSAGS SRRSSWNSLG RAPSLKRRSQ CGERESLLSG EGKGSTDDEA EDSRPNSGTH
PGASPGPRAT PLRRAESLGH RSTMDLCPPR PATLLPTKFR DCNGQMVALP SEFFLRIDSH
KEDAAEFDDD IEDSCCFRLH KVLEPYAPQW CSSRESWALY LFPPQNRLRV SCQKVIAHKM
FDHVVLVFIF LNCITIALER PDIDPGSTER AFLSVSNYIF TAIFVVEMMV KVVALGLLWG
EHAYLQSSWN VLDGLLVLVS LVDIIVAVAS AGGAKILGVL RVLRLLRTLR PLRVISRAPG
LKLVVETLIS SLRPIGNIVL ICCAFFIIFG ILGVQLFKGK FYYCEGTDTR NITTKAECHA
AHYRWVRRKY NFDNLGQALM SLFVLSSKDG WVNIMYDGLD AVGIDQQPVQ NHNPWMLLYF
ISFLLIVSFF VLNMFVGVVV ENFHKCRQHQ EAEEARRREE KRLRRLERRR RKAQRRPYYA
DYSHTRRSIH SLCTSHYLDL FITFIICLNV ITMSMEHYNQ PKSLDEALKY CNYVFTIVFV
FEAALKLVAF GFRRFFKDRW NQLDLAIVLL SIMGIALEEI EMNAALPINP TIIRIMRVLR
IARVLKLLKM ATGMRALLDT VVQALPQVGN LGLLFMLLFF IYAALGVELF GRLECSEDNP
CEGLSRHATF TNFGMAFLTL FRVSTGDNWN GIMKDTLREC TREDKHCLSY LPALSPVYFV
TFVLVAQFVL VNVVVAVLMK HLEESNKEAR EDAEMDAEIE LEIAQGSTAQ PPSTAQESQG
TEPDTPNLLV VRKVSVSRML SLPNDSYMFR PVAPAAAPHS HPLQEVEMET YTGPISCVLP
SQGQRPPLCP LTPGYAPLSE PLTDTLQTGG HARRVPGRAD R
//
