ID E0CZ22_MOUSE Unreviewed; 1640 AA.
AC E0CZ22;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Maestro heat-like repeat family member 1 {ECO:0000313|Ensembl:ENSMUSP00000094115.5};
GN Name=Mroh1 {ECO:0000313|Ensembl:ENSMUSP00000094115.5,
GN ECO:0000313|MGI:MGI:2442558};
GN Synonyms=Heatr7a {ECO:0000313|MGI:MGI:2442558};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000094115.5, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000094115.5, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000094115.5,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000094115.5}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000094115.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_780666.3; NM_175457.4.
DR AlphaFoldDB; E0CZ22; -.
DR STRING; 10090.ENSMUSP00000094115; -.
DR iPTMnet; E0CZ22; -.
DR PhosphoSitePlus; E0CZ22; -.
DR SwissPalm; E0CZ22; -.
DR MaxQB; E0CZ22; -.
DR PaxDb; 10090-ENSMUSP00000094115; -.
DR PeptideAtlas; E0CZ22; -.
DR ProteomicsDB; 363191; -.
DR Antibodypedia; 48391; 32 antibodies from 9 providers.
DR Ensembl; ENSMUST00000096385.11; ENSMUSP00000094115.5; ENSMUSG00000022558.17.
DR GeneID; 223658; -.
DR UCSC; uc007wkc.2; mouse.
DR AGR; MGI:2442558; -.
DR CTD; 727957; -.
DR MGI; MGI:2442558; Mroh1.
DR VEuPathDB; HostDB:ENSMUSG00000022558; -.
DR eggNOG; KOG2032; Eukaryota.
DR GeneTree; ENSGT00940000156930; -.
DR HOGENOM; CLU_003168_0_1_1; -.
DR InParanoid; E0CZ22; -.
DR OMA; EVYIKAM; -.
DR OrthoDB; 2873515at2759; -.
DR PhylomeDB; E0CZ22; -.
DR TreeFam; TF315201; -.
DR BioGRID-ORCS; 223658; 9 hits in 77 CRISPR screens.
DR ChiTaRS; Mroh1; mouse.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; E0CZ22; Protein.
DR Bgee; ENSMUSG00000022558; Expressed in yolk sac and 240 other cell types or tissues.
DR ExpressionAtlas; E0CZ22; baseline and differential.
DR Genevisible; E0CZ22; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR InterPro; IPR048465; Maestro_HEAT_rpt.
DR PANTHER; PTHR23120:SF44; MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 1; 1.
DR PANTHER; PTHR23120; MAESTRO-RELATED HEAT DOMAIN-CONTAINING; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF21047; Maestro_HEAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:E0CZ22,
KW ECO:0007829|MaxQB:E0CZ22};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 1610..1640
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 1640 AA; 181795 MW; 4F4C7832DB60CF1B CRC64;
MTRPYIKRLS FTLLDSITDK DPMVQEQVCS ALCSLGDAQP DETLHACEEY LRQHDKLAHP
YRTKILRAME TVLSSHIHDL DKDTAGAVIL LATSEMTRTK ELDCDWQQAA GSVLVAVGKR
FTNQVMEEVL SRFQPGMLPH SSVLHTLANL SVSNAFDMVP FLPSILSTML PMLSMAKQDA
LKVVFCGALQ HFSESILEYL ANLDQAPDPT VRKDTFGADI FGAYDVLFHH WLQSRDAKLR
LAVVAALGPM SHLLPSERLE EQLPKLLPAV LGLYKKHAEA FQISKSLGQI LEAAVNVSSR
TLEVQLDALL VALHAQICVP VESSSPLVMN SQKEVLRCFT VLACCSPDRL LAFLLPRLDT
SNERLRVGTL QILRHIINSA AAQMEAKQPF ILSSMRLPLL DTNDKVKRAV VQVISAMAHH
GYLEQPGGEV MVEYIVQQCA LPAEEPEKPG PDGEDLAADS VRAVSIRTLY LVSTTVDRMN
SVLWPYLLEF LTPVRFTAAL TPLCRSLVHL ALKRQEAGAD DFLIQYNANA NLPSPFAMTT
RLLVVSSNPY LGDGRGAASL RLLKVMHQNI HPFLGQRWET TMPMLLEYLD EHTEESLSLK
EWEEKLLMFL RDTLAVVSDN IWICQLSQEM CKQLPSYSGT PQEKNFLYKC IGTTLGAASS
KEVVRKHLRE LLETARYQEE AEQEGLACCF GICAITHLED TLAQLEDFVR SDVFRKSTGI
FSIFKDRSEH EVERMKSCLI LCYGHVAAQA PRELVLARVE SDILRSMFQC FNTKVLGIKV
ETKDPALKLC LVQSLCMVSQ AMCSSAQASS FHFLRKTELV TQMMEFIRAE PPDCLRTPIR
KKAMLACTYL VNLEPALEEQ TQADVVHSCL HSVMALPPEA EGGDGVGREP LYLDTVCALE
DLLTRLLRQN MTPQGLQIMV EHLSPWIKSP RGHERARALG LGACLLEFFQ EHLLVSTLVP
FHNLGLLVGL FAPRCADTWT TTRQKAVGCV YSLLYLQLGY EGFSRDHRDD VAERLLTLQD
GLVNADPTIL FHTCHSIAQV IAKRLPSDQL ISLLLTVFES LGDPDKNCSR AATVMINCLL
KERGNVLLEK VPEIVSVLRA KLRDTQEEHV LPAAQHSVYL LASQHCEAVV SSLLGSPLPF
DSHTCALWRA LAVEPGLTAQ VLELLLEKMS KDVPFKESRA FLLGSTADRV ATLLPLAATC
ALYEVLSAPS SGTVVLELYP QLFAALLLRV SCTVGVQLPR NLQAKERRST SPARAARNLD
PCSSAVDALQ ALLLRSGSQD MLRCVELERG WELLKTSAGH EDGVAQLASS MAKYAGPRLP
PVTKALACTQ NSVYEIQRVT STAFLAELLS SNVVNDLMLL EPLLDNLTAR LKDSSASVRR
LVLRGLANMA SGSPDKVRAH GPQLLTAMVS GLDDGDEPHS PVALEAMVGL SRLLDLVEPW
DLRLVLLHTT IRIRPFFDSE KVEFRTASIR LFGHLNKACH GDCEDVFLEQ VVGGLVPLLL
HLRDPQVPVA SACKFALCMC VPHLECAELA AAFYKYLQEG RSVHFGEFLN STCKHLMHHF
PDLLGRLVST NLFYFKSSWD DVRAAAPMFT GFLVLHAEPE QKTQVDLEQL IVALQLLLKD
PVPGVREKAA ETLGRLVKFA
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