ID E0CZ86_MOUSE Unreviewed; 166 AA.
AC E0CZ86;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Endothelin-3 {ECO:0000256|ARBA:ARBA00040198};
DE AltName: Full=Preproendothelin-3 {ECO:0000256|ARBA:ARBA00041850};
GN Name=Edn3 {ECO:0000313|Ensembl:ENSMUSP00000125602.2,
GN ECO:0000313|MGI:MGI:95285};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000125602.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000125602.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000125602.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000125602.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000125602.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.
CC {ECO:0000256|ARBA:ARBA00003023}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC {ECO:0000256|ARBA:ARBA00010959}.
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DR AlphaFoldDB; E0CZ86; -.
DR ProteomicsDB; 371260; -.
DR Antibodypedia; 29284; 329 antibodies from 30 providers.
DR Ensembl; ENSMUST00000140908.2; ENSMUSP00000125602.2; ENSMUSG00000027524.10.
DR AGR; MGI:95285; -.
DR MGI; MGI:95285; Edn3.
DR VEuPathDB; HostDB:ENSMUSG00000027524; -.
DR GeneTree; ENSGT00950000183053; -.
DR HOGENOM; CLU_090013_0_0_1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000027524; Expressed in iris and 132 other cell types or tissues.
DR ExpressionAtlas; E0CZ86; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR InterPro; IPR020475; Endothelin.
DR InterPro; IPR019764; Endothelin_toxin_CS.
DR InterPro; IPR001928; Endothln-like_toxin.
DR PANTHER; PTHR13874; ENDOTHELIN; 1.
DR PANTHER; PTHR13874:SF11; ENDOTHELIN-3; 1.
DR Pfam; PF00322; Endothelin; 1.
DR PRINTS; PR00365; ENDOTHELIN.
DR SMART; SM00272; END; 2.
DR PROSITE; PS00270; ENDOTHELIN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:E0CZ86};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasoconstrictor {ECO:0000256|ARBA:ARBA00023322}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..166
FT /note="Endothelin-3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003133296"
FT DOMAIN 52..73
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
FT DOMAIN 114..135
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
FT REGION 22..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 166 AA; 18636 MW; 41C0F30EBE4998C1 CRC64;
MEPGLWLLLG LTVTSAAVAL PAQPESAGQE RAPGRSGKQE DKGLPAHHRP RRCTCFTYKD
KECVYYCHLD IIWINTPEQT VPYGLSNYRE SLRGKRSLGP VPESSQPSPW TRLRCTCMGA
DDKACAHFCA RTRDVTRAER PAAEEMRETG GPRQRLMSRT DKAHRP
//
