ID E0DIS0_9CORY Unreviewed; 348 AA.
AC E0DIS0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=HMPREF0299_5585 {ECO:0000313|EMBL:EFM47812.1};
OS Corynebacterium matruchotii ATCC 14266.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=553207 {ECO:0000313|EMBL:EFM47812.1, ECO:0000313|Proteomes:UP000004218};
RN [1] {ECO:0000313|EMBL:EFM47812.1, ECO:0000313|Proteomes:UP000004218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14266 {ECO:0000313|EMBL:EFM47812.1,
RC ECO:0000313|Proteomes:UP000004218};
RA Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Nelson K.E.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM47812.1}.
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DR EMBL; ACSH02000008; EFM47812.1; -; Genomic_DNA.
DR RefSeq; WP_005527050.1; NZ_ACSH02000008.1.
DR AlphaFoldDB; E0DIS0; -.
DR STRING; 553207.HMPREF0299_5585; -.
DR eggNOG; COG1024; Bacteria.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000004218; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:EFM47812.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004218}.
FT DOMAIN 15..338
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 348 AA; 38458 MW; 456335D8D28E17AC CRC64;
MTDQLVIARQ EHTTGVLELN RPRALNSLTS DMVRIIDQHL AEWATDPQIT QVLIYSNSPK
AFCAGGDVRL AREYLLAGTP ERADEFFAAE YVMNGNIAHF PKPYIALIDG IAMGGGLGIS
VHGSHRIVTE NALAAMPEMA IGFMPDVGMS YMMQHMVGTY GRKSPAVARF LAITGYRLDP
ADMLYTGLAT HYVSRQNLDA LHRDIIEYGV DKALATYQET SPENPQLKTY IDDIEAAFGH
PTWDEIDHRL TGELRDLVHQ HIAHASPSAI VAALELITAA GTKTDIRHEL ALEIPFGEYI
RRQPDFAEGV RAVLVDKRPD AQFQPKTFAD VDPAPYRKIL SYSAADGN
//