ID   E0E2J9_9FIRM            Unreviewed;       215 AA.
AC   E0E2J9;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Na+/H+ antiporter family protein {ECO:0000313|EMBL:EFM64883.1};
GN   ORFNames=HMPREF0634_1438 {ECO:0000313|EMBL:EFM64883.1};
OS   Peptostreptococcus stomatis DSM 17678.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Peptostreptococcus.
OX   NCBI_TaxID=596315 {ECO:0000313|EMBL:EFM64883.1, ECO:0000313|Proteomes:UP000003244};
RN   [1] {ECO:0000313|EMBL:EFM64883.1, ECO:0000313|Proteomes:UP000003244}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17678 {ECO:0000313|EMBL:EFM64883.1,
RC   ECO:0000313|Proteomes:UP000003244};
RA   Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA   Nelson K.E.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC       family. {ECO:0000256|ARBA:ARBA00038435}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFM64883.1}.
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DR   EMBL; ADGQ01000038; EFM64883.1; -; Genomic_DNA.
DR   AlphaFoldDB; E0E2J9; -.
DR   eggNOG; COG1757; Bacteria.
DR   Proteomes; UP000003244; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR   PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR   PANTHER; PTHR33451:SF4; NA+_H+ ANTIPORTER-RELATED; 1.
DR   Pfam; PF03553; Na_H_antiporter; 2.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003244};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        31..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        73..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        112..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..95
FT                   /note="Na+/H+ antiporter NhaC-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03553"
FT   DOMAIN          107..207
FT                   /note="Na+/H+ antiporter NhaC-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03553"
SQ   SEQUENCE   215 AA;  22262 MW;  A47F993D53209050 CRC64;
     MLAGAFSTVS KQMGGVDSVV NLGMSVLPPQ YITVGIFIIS CFIAISTGIS VGTVVAVAPI
     AIGFAQAAGI SEAMVIGATI SGGIILSGII GISDGSFTAL VFSQQIFEGF KGMLDIFLLS
     MFTGGLAYMV EREGGINWII KQVRKIIKGK KSAELGISAM VSLTDLATAN NTVAILINGP
     IAKEISEEYG IEPKRAASLL DIFSCVFQGL IPYGA
//