ID E0NM27_9FIRM Unreviewed; 777 AA.
AC E0NM27;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Penicillin-binding protein, transpeptidase domain protein {ECO:0000313|EMBL:EFM25082.1};
DE EC=2.3.2.- {ECO:0000313|EMBL:EFM25082.1};
GN Name=pbpB {ECO:0000313|EMBL:EFM25082.1};
GN ORFNames=HMPREF9225_1216 {ECO:0000313|EMBL:EFM25082.1};
OS Peptoniphilus duerdenii ATCC BAA-1640.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC Peptoniphilus.
OX NCBI_TaxID=862517 {ECO:0000313|EMBL:EFM25082.1, ECO:0000313|Proteomes:UP000003280};
RN [1] {ECO:0000313|EMBL:EFM25082.1, ECO:0000313|Proteomes:UP000003280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1640 {ECO:0000313|EMBL:EFM25082.1,
RC ECO:0000313|Proteomes:UP000003280};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM25082.1}.
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DR EMBL; AEEH01000044; EFM25082.1; -; Genomic_DNA.
DR RefSeq; WP_008902030.1; NZ_GL397071.1.
DR AlphaFoldDB; E0NM27; -.
DR STRING; 862517.HMPREF9225_1216; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_0_9; -.
DR Proteomes; UP000003280; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR CDD; cd06577; PASTA_pknB; 1.
DR Gene3D; 3.30.10.20; -; 1.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 2.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 2.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 1.
DR PROSITE; PS51178; PASTA; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:EFM25082.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003280};
KW Transferase {ECO:0000313|EMBL:EFM25082.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 631..695
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 696..752
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT REGION 758..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 87210 MW; 46CEC5ED8F6FE5DD CRC64;
MKRRKNKTTR GSFKGDIRTV FNRRIFFLLS FLVLFFILLV FRLFYIQIFK SEDLTKQALN
QLTKKESINS NRGLIYDANK KILALNVSKS KIYYDSNNIK PDKGMQKGKK ESEEAYKKRM
DDFAAIRQKK LEDDARYFSN ILNLDERETL VKISQNKRVT LAKDVDRKIA LEIREQKNKC
VSFDDYIKRF YPFGKSMSHV LGFLDNENYG IYGLERQFDD ELVGIKGKSI KIKDEQLKQI
PMTDEKQYAP QDGLDLVSTI DVNIQGFADK AAEESKLKTE AERVTVIVQN TKTGEILAMV
DKDDYDPNYP RLPINEKQEK DFKNLSEEEL LKAWSDNWKN SSIESQYEPG STFKLITAAS
ALEEDTTNLQ KTYTCPGVLT DMKGVRITCT SSRRGSKTLA EAMAESCNIS LVKIGRELGA
EKFLKFIRSF GFGERTGIDL RGEVKGTIPA SANQISKVAI STISYGHGIA VTPIQLINAV
SAIGNGGYLN KPLIVKELVD KEGNVIEKFK KTTYRRVISE ETSKTMRELM RGVVEEGTGK
YAAVPGYKVG GKTGTAYIAS SKGGYEDEYY SSFIGLAPIK DPVITVLVVV KKPVGNFYGA
TVAAPVAKEV MQETLEYLKI PKTEKIDKVD NKEQVVVPDV TGRLVMDAGK IIVNSNLKFS
SDKSKVTENS VVVSQRPAAG EMVPQGSIVD ITVNENTEKM VPMLIGKSKE DAEKVLSELG
IKYKIEGEGY ITSQSIKAKT IVTDEVIVLT TDRDFDKVEE SVINNDKNNK NEDKNKN
//
