ID E0V9C1_PEDHC Unreviewed; 802 AA.
AC E0V9C1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 13-SEP-2023, entry version 67.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=8233533 {ECO:0000313|EnsemblMetazoa:PHUM008080-PA};
GN ORFNames=Phum_PHUM008080 {ECO:0000313|EMBL:EEB09977.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB09977.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB09977.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB09977.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB09977.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM008080-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM008080-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; AAZO01000096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS234991; EEB09977.1; -; Genomic_DNA.
DR RefSeq; XP_002422715.1; XM_002422670.1.
DR AlphaFoldDB; E0V9C1; -.
DR STRING; 121224.E0V9C1; -.
DR EnsemblMetazoa; PHUM008080-RA; PHUM008080-PA; PHUM008080.
DR GeneID; 8233533; -.
DR KEGG; phu:Phum_PHUM008080; -.
DR CTD; 8233533; -.
DR VEuPathDB; VectorBase:PHUM008080; -.
DR eggNOG; KOG4171; Eukaryota.
DR HOGENOM; CLU_011356_0_0_1; -.
DR InParanoid; E0V9C1; -.
DR OMA; CRVEEMS; -.
DR OrthoDB; 2898719at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF10; SOLUBLE GUANYLATE CYCLASE 88E; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 425..553
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 750..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 361..395
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 802 AA; 92041 MW; 80166CF6BC1B7FE3 CRC64;
MYGLLLENLA EYIKQVYGEE RWEEIRRLAS VEQPSFSVHQ VYPETLIPRL AKKAIQVLNV
SEREFFDQMG VHFVGFVGQY GYDRVLSVLG RHMRDFLNGL DNLHEYLKFS YPRMRAPSFI
CENETRQGLT LHYRSKRRGF VYYTMGQIRE VARHFYHKEM RIELVREEIL FDTVHVTFQL
TFDNRAFTLA SLTMTREEKH LPISASVLFE IFPFCIVFGS DMIVRSIGNS LMVILPDLVS
KKITNWFDLV RPLIAFKFQT ILNRTNNIFE LVTVEPVLTE RPTDRKRNYL ILSDESDDSP
NEKHLRLKGQ MVYMDNWKMM MYLGTPVMPD LNALVTTGLY INDLSMHDFS RDLMLAGTQQ
SVELKLALDQ EQSKSKKLEE SMRKLDEEMK RTDELLYQMI PKQVADRLRA GENPIDTCQI
FNSVSILFSD VVSFTEICSR IAPMEVVSML NAMYSIFDTL TERNRVYKVE TIGDAYMVVS
GAPEKELNHA EKVCDMALDM VEAITDLKDP STGSHLQIRV GIHSGAVVAG IVGLKMPRYC
LFGDTVNTAS RMESTSEAMK IHISQSTRDL ISNVYEVTER GEIQLKGKGA TKTYWLNKRE
CRTPLSRSIA TKGVETEWEK SADLRGSMMG LVTLDDEDRN RIVKGSTLGF RLEQEEKKGS
GISVENRRVY SPVTFQDIAR RSIGNSPIKT TVSRSNSMGA SLLPLPITEI SSSRKREDDE
SDIYAKEATE IINSKAKTLE ALEAVAFASS TPSTLNSPEP NETEIDETEQ LNSNPYLIRQ
ELNRLPQILY KGNYYYYYYY FA
//
