ID E0V9L3_PEDHC Unreviewed; 435 AA.
AC E0V9L3;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Class B secretin-like G-protein coupled receptor GPRcal3, putative {ECO:0000313|EMBL:EEB10069.1, ECO:0000313|EnsemblMetazoa:PHUM015970-PA};
GN Name=8233768 {ECO:0000313|EnsemblMetazoa:PHUM015970-PA};
GN ORFNames=Phum_PHUM015970 {ECO:0000313|EMBL:EEB10069.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB10069.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10069.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB10069.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10069.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM015970-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM015970-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000256|ARBA:ARBA00005314}.
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DR EMBL; AAZO01000188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS234994; EEB10069.1; -; Genomic_DNA.
DR RefSeq; XP_002422807.1; XM_002422762.1.
DR AlphaFoldDB; E0V9L3; -.
DR STRING; 121224.E0V9L3; -.
DR EnsemblMetazoa; PHUM015970-RA; PHUM015970-PA; PHUM015970.
DR GeneID; 8233768; -.
DR KEGG; phu:Phum_PHUM015970; -.
DR CTD; 8233768; -.
DR VEuPathDB; VectorBase:PHUM015970; -.
DR eggNOG; KOG4564; Eukaryota.
DR HOGENOM; CLU_002753_4_2_1; -.
DR InParanoid; E0V9L3; -.
DR OMA; ILGWVFP; -.
DR OrthoDB; 2878353at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EEB10069.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..435
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011412305"
FT TRANSMEM 202..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..196
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 201..379
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 435 AA; 50614 MW; EC2A235E2A7518D9 CRC64;
MKNFLFFTFL LPIVHPQGTP FKNENLCRTR NDIYLPYDEF NMDSCVLCYR FMSNYSFKEN
SPLDLSVIET IMKNHSSYQD LMENETILKS FINSVAVNKW KECCKSASDC CTSMIANKTQ
KVENWCPRTW DGWLCWPDIK PGNQERKLCP NYVLTNMENC TNSFALKTCE KNGKWAHHPF
DKNNEWTNYT PCSAKPMIEK RMYVTIGSYA LSVIALVPAL IIFQKFRSLR CHRIILHKNL
FASLLFHCST QIAFNSEFIL DDLSGNSRIS KNELSCKALL VATKYFRLTN YFWMFCEGFY
LHRQIVNVFA EEASLTIFYI IVPIIPVAIF IAFRKAIHDT DCWALPSDYI DWALHLPSVK
ATLVLVPLFG IHFLFTLYRQ KSVCSSIEGA YAYIRSTFDG LQGFLVAVIF CYVNSEFVFY
NTDVTLLIYK ENLYM
//
