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Database: UniProt
Entry: E0VBI6_PEDHC
LinkDB: E0VBI6_PEDHC
Original site: E0VBI6_PEDHC 
ID   E0VBI6_PEDHC            Unreviewed;      4516 AA.
AC   E0VBI6;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 74.
DE   SubName: Full=Dynein heavy chain, cytosolic, putative {ECO:0000313|EMBL:EEB10742.1, ECO:0000313|EnsemblMetazoa:PHUM061490-PA};
GN   Name=8231008 {ECO:0000313|EnsemblMetazoa:PHUM061490-PA};
GN   ORFNames=Phum_PHUM061490 {ECO:0000313|EMBL:EEB10742.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC   Pediculus.
OX   NCBI_TaxID=121224;
RN   [1] {ECO:0000313|EMBL:EEB10742.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB10742.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB10742.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB10742.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:PHUM061490-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM061490-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; AAZO01000719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS235030; EEB10742.1; -; Genomic_DNA.
DR   RefSeq; XP_002423480.1; XM_002423435.1.
DR   STRING; 121224.E0VBI6; -.
DR   EnsemblMetazoa; PHUM061490-RA; PHUM061490-PA; PHUM061490.
DR   GeneID; 8231008; -.
DR   KEGG; phu:Phum_PHUM061490; -.
DR   CTD; 8231008; -.
DR   VEuPathDB; VectorBase:PHUM061490; -.
DR   eggNOG; KOG3595; Eukaryota.
DR   HOGENOM; CLU_000038_7_0_1; -.
DR   InParanoid; E0VBI6; -.
DR   OMA; EMYGGKI; -.
DR   OrthoDB; 312195at2759; -.
DR   Proteomes; UP000009046; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   CDD; cd00009; AAA; 2.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 2.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF23; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 4.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1767..1904
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2076..2227
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2448..2598
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2790..2956
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   COILED          411..438
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1038..1065
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1145..1172
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3069..3138
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3271..3347
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   4516 AA;  517814 MW;  5B2E7921942AC4A4 CRC64;
     MSQIRVINFS EDSPYETLHA FVSKSLAPYF KSYIKESGRA EREGDKMVPS VEKKMTELEM
     GLLHLQQNID IPEISLQVHP SVANVVKKCS EEGRKPKVVD FGDLVEDSTF LNQLQNGVNR
     WIKEIQKVTK LDRDPSSGTA LQEISFWLNL ERALYRIQEK RESPEVTLTL DILKHGKRFH
     ATVSFDTDTG LKQALATVND YNPLMKDFPI NDLLSATELE RIRVAVEMIF NHLRKIRSTK
     YPIQRALRLV EAISRDLSSQ LLKVLGTRLL MHKPFDEFEK VLTQCFDIFT TWEDEYDKLQ
     GLLRDIMKKK RDENIKLVWR ILPSHKRLQN RMEQMRRFRR QHEQLRSVIV RVLPPVSAAG
     KRNVEDGMSS EEVEEGLKIL ETADANAIEE VNLAYDNVKE VDCLDISKEG NALWDAAVQR
     YEDRIDRVEA RITAHLRDQL GTAKNANEMF RIFSRFNALF VRPHIRGAIR EYQTQLIQRV
     KDDIEALHEK FKVQYPQSKA CRMSRVRDIP PVAGSIIWAQ QIDRQLTAYL RRVEDVLGKG
     WENHIEGQKL KADGDSFRLK LNTTEIFEDW ARRVQQRNMG VSGRIFTIET ARSRTGRGNI
     LKLKVNFLPE IITLSKEVRN LRHLGFRVPL AIVNKAHQAN TLYPFAISLI ESIRTYERTL
     EKIEHKSIIA PLVAGMRQDV QNLIAEGIDL VWESYKLDPY VERLAETVFS FQEKVEDLLV
     VEEQLDLDVR SLETCAYSAQ TFSEILSKIQ HSVDELSLRQ YSNLHIWVQK LYENVEKHMA
     ARLQAGIEAW TDTLKGKKKD IDLTMDTDLP TENPKKIGGE PQIPQMVLEV RIKNQAMYLF
     PSIEEARFQL MQQMFAWQAI VTSQQRLQSS RYHVGLEKPT LESYKHLLTK LPGGPEVLAK
     AYEAIEYKIK EVQNYSAEWF CYQALWDLQA DNVYGKLGQD INLWMKCLND IKKTRTTFDT
     SETRREFGPV VFDYAKVQSK VSLKYDSWHK DTLAKFGALL GNEMNSFHAQ VNKSRTELEQ
     QSIEAASTSD AVTFITYVQS LKKQMKAWEK QVELYRESQR ILERQRFQFP QQWLHVDNIE
     GEWSAFNEII KRKDSSIQTQ VASLQVKIVA ENKLVEARTS DLFNEWEKTK PVEGSIRPSD
     ALRQLQTFEA KFSKLKEERD NVSKAKEALE LQEPGGISSS EDKMQVVFEE MQDLRGVWSE
     LSSIWSQIDE IREKPWLSVQ PRKLRQQLDA LLTQLKDLPA RLRQYASYEF VRKMLQNYVK
     VNMLIVELKS DALKERHWKV LMKHLKVNWI LSELTLGQVW DVNLLKNDSI VKDIILVAQG
     EMALEEFLKQ VRESWQHYQL DMINYQNKCK IIRGWDDLFN KVKEHINSVA AMKLSPYYKV
     FEEEALTWEE KLNRINALFD VWIDVQRRWV YLEGIFSGSA DIKTLLPVET SRFQSISSEF
     LGLMKKVSKS PMVIDVLNIP GVQRSLERLA DLLGKIQKAL GEYLERERTS FPRFYFVGDE
     DLLEIIGNSK NIGRLQKHFK KMFAGVAALT LSKEDTVITG LSSREGEEVI FTEEISTVEN
     PKINEWLTLV EKQMRITLAS CLANAVKDIK QFKEGPINAE EYMKWCDRYQ AQIVVLAAQI
     LWSEDVEEAL VHIHNSTDRN MKPLEHVLNQ VEATLNILAD SVLQEQPPLR RKKLEHLINE
     FVHKRTVTRR LISNGVTSPK AFEWLCEMRF YFDPRQTEAL RQLTIHMANA KFYYGFEYLG
     VQDRLVQTPL TDRCYLTMTQ ALETRLGGSP FGPAGTGKTE SVKALGHQLG RFVLVFNCDE
     TFDFQAMGRI FVGLCQVGAW GCFDEFNRLE ERMLSAVSQQ IQAIQEALKS QKEGSISVEI
     VGKQVKVSTD MAIFITMNPG YAGRSNLPDN LKKLFRSLAM TKPDRQLIAE VMLFSQGFRS
     AEKLACKIVP FFKLCDEQLS NQSHYDFGLR ALKSVLVSAG NVKRDRIQRI KENLKNKGDS
     NTDEASIAEN LPEQAILIQS VCETMVPKLV AEDIPLLFSL LSDVFPNVSY TRAEMTKLKE
     EIKKVCQEEY LTCGEGEETG GAWMEKVLQL YQICNLNHGL MMVGPSGSGK TAAWKVLLKA
     LERLEGVEGV AHVIDPKAIS KEALYGVLDA NTREWTDGLF THILRKIIDN VRGEINKRQW
     IIFDGDVDPE WVENLNSVLD DNKLLTLPNG ERLSLPPNVR IMFEVQDLKY ATLATVSRCG
     MVWFSEDILL TEMIFENYLS KLKNIPLEGE DERETSIGSK TNEKKMDDVL SPTMQVQRDV
     ALILTPYFGP DALVVRCLEF AIKQEHIMDF TRLRALNSLF SMLNQGVRNV LEHNESHPDF
     PLSNEQLEAY IPKCLVYSLL WSFSGDSKLK VRSNLGDFIR SITTIPLPVS TNLPIIDYEV
     NVLGDWAPWS NKVPQIEIET HKVAAPDVVV PTLDTVRHES LLYTWLAEHK PLVLCGPPGS
     GKTMTLFSAL RALPDMEVVG LNFSSATTPE LLLKTFDHYC EYRKTPNGVI LSPVQLGKWL
     ILFCDEINLP DMDRYGTQRV ISFLRQLVEH RGFYRSSDQA WVSLERIQFV GACNPPTDPG
     RKPLSHRFLR HVPVIYVDYP GETSLKQIYG TFSRAMLRLV PTLRGFAEPL TNAMVEFYLV
     SQEKFTQDMQ PHYVYSPREM TRWVRGICEA IRPLDTISSE GLVRIWAHEA LRLFQDRLVE
     DHERKWTNEN IDAVAIKHFP GINKETALAR PILYSNWLTK DYLPVNREEL RDYVKARLKV
     FYEEELDVQL VLFDEVLDHV LRIDRIFRQP QGHLLLIGAS GAGKTTLSRF VAWMNGLSVF
     QIKVHNKYTG EDFDEDLRSV LKRSGCKDEK IAFILDESNV LESGFLERMN TLLANGEVPG
     LFEGDEYTTL ITQCKEGAQR EGLMLDSNEE LYKWFTGQVM KNLHVVFTMN PSSEGLKDRA
     ATSPALFNRC VLNWFGDWSD GALYQVGMEF TNRIDLDRPT WTPPDTLPIT NHRLPAHPTH
     REAVINAFVY VHETLHKANA RLTKRGGRTT TITPRHYLDF INHFVKLYNE KRSDLEEQQL
     HLNVGLNKIA ETVEQVEEMQ KSLAVKSREL NEKNEAANAK LRQIVKDQHE AEKKKLQSEE
     IQEALEKQTI QIAQKREDVM VDLAQVEPAV IDAQQAVKSI KKQYLVEIRS MANPPAIVKL
     ALESICLLLG ENATDWKAIR AVIMRENFIN SIVQNFSTEG ITDEMREKMK IKYLSNPDYN
     FEKVNRASLA CGPMVKWAIA QINYADMLKR VEPLRDELKS LEVQADENKN KYEEVKNLIS
     QFEQSISSYK DEYALLISQA HAIKIDLENI QAKVDRSRAL LRSLAIESER WESTSETFKS
     QMSSIIGDVL LSSAFLSYAG YFDQHYRQNL FTTWCHHLQQ AGIQFRLDIA RTEYLSNPDE
     RLRWQANALP TDDLCTENAI MLKRFNRYPL IIDPSGQATE FIMNEFADRK ITKTSFLDDS
     FRKNLESALR FGNPLLVQDV ENYDPILNPV LNRELRRTGG RVLITLGDQD IDLSPSFVIF
     LSTRDPTVEF PPDICSRVTF VNFTVTRSSL QSQCLNQVLK AERPDIDEKR SDLLKLQGEF
     HLRLRQLEKS LLQALNDAKG KILDDDSVIT TLETLKKEAE DISRKVEETD KVIAEIETVS
     LQYLPLSQAC SNIYFTMDSL NQIHFLYQYS LKFFLEIFSS VLHNNSELAN LTDNAARLGV
     ITKTLFSVCY ERVARGMLHA DRLTFALLLC RIHLKGVPNE SVFDEEFHFF LRGKEGMLDV
     NPPAIEGLNQ EQLEAIMRIS TKLKPFRNIA KIITSMPEFG AWLQQSTPEQ NVPKLWENVT
     LSDIGDAMYQ LLAIQTFRPD RVIAAATQFV SVVLGEDFMP MAEKELNLAE RWESELRANV
     PILLCSVPGY DASGRVDDLA VELKVPLASI AIGSAEGFSQ AEKAINVAVK SGRWVLLKNV
     HLAPQWLVQL EKKLHSIQPH SNFRLFLTME INLKLPVNLL RAGRIFVFEP PPGIRANLLR
     TFSTVSAQRM MKAPSERARL YFLLAWFHAI VQERLRYAPL GWAKYYEFNE SDLRVACDTL
     DTWIEATAMG RTNLPPEKVP WDALVTLLSQ CIYGGKIDND FDQRLLASFL AKLFTPKSFE
     TDFALVANVD GVAGGPGGQR HITMPDGNRR DQFLQWIEAL SDRQTPSWLG LPNNAEKVLL
     TTLGTDLVGK LLKMQQLEDD EELAYSPDES LDQTIVQDVD GRPSWMKTLH NSATTWLQLL
     PKSLKTLRRT VENIKDPIYR YFEREVNLGS KLLSDVIHDL EDISLICRGD KKQTNYHRAM
     LSDLVKGILP GHWRRYTVPR GCTVIQWITD FSQRIKQLQE VSKVVSNKGA KELKSFNVWL
     GGLLNPEAYV TATRQSVAQA NGWSLEELVL DITISDGNDV NADDCSFAVI GLKLQGAQCR
     NNQLHLTSAI MTELPMTLLR WVRASAVSNG KLSLPVYLNS TRTELLFTVD LNIAAGQERH
     SFYERGVALL TSTALN
//
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