ID E0VBI6_PEDHC Unreviewed; 4516 AA.
AC E0VBI6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE SubName: Full=Dynein heavy chain, cytosolic, putative {ECO:0000313|EMBL:EEB10742.1, ECO:0000313|EnsemblMetazoa:PHUM061490-PA};
GN Name=8231008 {ECO:0000313|EnsemblMetazoa:PHUM061490-PA};
GN ORFNames=Phum_PHUM061490 {ECO:0000313|EMBL:EEB10742.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB10742.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10742.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB10742.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10742.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM061490-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM061490-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AAZO01000719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235030; EEB10742.1; -; Genomic_DNA.
DR RefSeq; XP_002423480.1; XM_002423435.1.
DR STRING; 121224.E0VBI6; -.
DR EnsemblMetazoa; PHUM061490-RA; PHUM061490-PA; PHUM061490.
DR GeneID; 8231008; -.
DR KEGG; phu:Phum_PHUM061490; -.
DR CTD; 8231008; -.
DR VEuPathDB; VectorBase:PHUM061490; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_7_0_1; -.
DR InParanoid; E0VBI6; -.
DR OMA; EMYGGKI; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF23; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1767..1904
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2076..2227
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2448..2598
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2790..2956
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 411..438
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1038..1065
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1145..1172
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3069..3138
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3271..3347
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4516 AA; 517814 MW; 5B2E7921942AC4A4 CRC64;
MSQIRVINFS EDSPYETLHA FVSKSLAPYF KSYIKESGRA EREGDKMVPS VEKKMTELEM
GLLHLQQNID IPEISLQVHP SVANVVKKCS EEGRKPKVVD FGDLVEDSTF LNQLQNGVNR
WIKEIQKVTK LDRDPSSGTA LQEISFWLNL ERALYRIQEK RESPEVTLTL DILKHGKRFH
ATVSFDTDTG LKQALATVND YNPLMKDFPI NDLLSATELE RIRVAVEMIF NHLRKIRSTK
YPIQRALRLV EAISRDLSSQ LLKVLGTRLL MHKPFDEFEK VLTQCFDIFT TWEDEYDKLQ
GLLRDIMKKK RDENIKLVWR ILPSHKRLQN RMEQMRRFRR QHEQLRSVIV RVLPPVSAAG
KRNVEDGMSS EEVEEGLKIL ETADANAIEE VNLAYDNVKE VDCLDISKEG NALWDAAVQR
YEDRIDRVEA RITAHLRDQL GTAKNANEMF RIFSRFNALF VRPHIRGAIR EYQTQLIQRV
KDDIEALHEK FKVQYPQSKA CRMSRVRDIP PVAGSIIWAQ QIDRQLTAYL RRVEDVLGKG
WENHIEGQKL KADGDSFRLK LNTTEIFEDW ARRVQQRNMG VSGRIFTIET ARSRTGRGNI
LKLKVNFLPE IITLSKEVRN LRHLGFRVPL AIVNKAHQAN TLYPFAISLI ESIRTYERTL
EKIEHKSIIA PLVAGMRQDV QNLIAEGIDL VWESYKLDPY VERLAETVFS FQEKVEDLLV
VEEQLDLDVR SLETCAYSAQ TFSEILSKIQ HSVDELSLRQ YSNLHIWVQK LYENVEKHMA
ARLQAGIEAW TDTLKGKKKD IDLTMDTDLP TENPKKIGGE PQIPQMVLEV RIKNQAMYLF
PSIEEARFQL MQQMFAWQAI VTSQQRLQSS RYHVGLEKPT LESYKHLLTK LPGGPEVLAK
AYEAIEYKIK EVQNYSAEWF CYQALWDLQA DNVYGKLGQD INLWMKCLND IKKTRTTFDT
SETRREFGPV VFDYAKVQSK VSLKYDSWHK DTLAKFGALL GNEMNSFHAQ VNKSRTELEQ
QSIEAASTSD AVTFITYVQS LKKQMKAWEK QVELYRESQR ILERQRFQFP QQWLHVDNIE
GEWSAFNEII KRKDSSIQTQ VASLQVKIVA ENKLVEARTS DLFNEWEKTK PVEGSIRPSD
ALRQLQTFEA KFSKLKEERD NVSKAKEALE LQEPGGISSS EDKMQVVFEE MQDLRGVWSE
LSSIWSQIDE IREKPWLSVQ PRKLRQQLDA LLTQLKDLPA RLRQYASYEF VRKMLQNYVK
VNMLIVELKS DALKERHWKV LMKHLKVNWI LSELTLGQVW DVNLLKNDSI VKDIILVAQG
EMALEEFLKQ VRESWQHYQL DMINYQNKCK IIRGWDDLFN KVKEHINSVA AMKLSPYYKV
FEEEALTWEE KLNRINALFD VWIDVQRRWV YLEGIFSGSA DIKTLLPVET SRFQSISSEF
LGLMKKVSKS PMVIDVLNIP GVQRSLERLA DLLGKIQKAL GEYLERERTS FPRFYFVGDE
DLLEIIGNSK NIGRLQKHFK KMFAGVAALT LSKEDTVITG LSSREGEEVI FTEEISTVEN
PKINEWLTLV EKQMRITLAS CLANAVKDIK QFKEGPINAE EYMKWCDRYQ AQIVVLAAQI
LWSEDVEEAL VHIHNSTDRN MKPLEHVLNQ VEATLNILAD SVLQEQPPLR RKKLEHLINE
FVHKRTVTRR LISNGVTSPK AFEWLCEMRF YFDPRQTEAL RQLTIHMANA KFYYGFEYLG
VQDRLVQTPL TDRCYLTMTQ ALETRLGGSP FGPAGTGKTE SVKALGHQLG RFVLVFNCDE
TFDFQAMGRI FVGLCQVGAW GCFDEFNRLE ERMLSAVSQQ IQAIQEALKS QKEGSISVEI
VGKQVKVSTD MAIFITMNPG YAGRSNLPDN LKKLFRSLAM TKPDRQLIAE VMLFSQGFRS
AEKLACKIVP FFKLCDEQLS NQSHYDFGLR ALKSVLVSAG NVKRDRIQRI KENLKNKGDS
NTDEASIAEN LPEQAILIQS VCETMVPKLV AEDIPLLFSL LSDVFPNVSY TRAEMTKLKE
EIKKVCQEEY LTCGEGEETG GAWMEKVLQL YQICNLNHGL MMVGPSGSGK TAAWKVLLKA
LERLEGVEGV AHVIDPKAIS KEALYGVLDA NTREWTDGLF THILRKIIDN VRGEINKRQW
IIFDGDVDPE WVENLNSVLD DNKLLTLPNG ERLSLPPNVR IMFEVQDLKY ATLATVSRCG
MVWFSEDILL TEMIFENYLS KLKNIPLEGE DERETSIGSK TNEKKMDDVL SPTMQVQRDV
ALILTPYFGP DALVVRCLEF AIKQEHIMDF TRLRALNSLF SMLNQGVRNV LEHNESHPDF
PLSNEQLEAY IPKCLVYSLL WSFSGDSKLK VRSNLGDFIR SITTIPLPVS TNLPIIDYEV
NVLGDWAPWS NKVPQIEIET HKVAAPDVVV PTLDTVRHES LLYTWLAEHK PLVLCGPPGS
GKTMTLFSAL RALPDMEVVG LNFSSATTPE LLLKTFDHYC EYRKTPNGVI LSPVQLGKWL
ILFCDEINLP DMDRYGTQRV ISFLRQLVEH RGFYRSSDQA WVSLERIQFV GACNPPTDPG
RKPLSHRFLR HVPVIYVDYP GETSLKQIYG TFSRAMLRLV PTLRGFAEPL TNAMVEFYLV
SQEKFTQDMQ PHYVYSPREM TRWVRGICEA IRPLDTISSE GLVRIWAHEA LRLFQDRLVE
DHERKWTNEN IDAVAIKHFP GINKETALAR PILYSNWLTK DYLPVNREEL RDYVKARLKV
FYEEELDVQL VLFDEVLDHV LRIDRIFRQP QGHLLLIGAS GAGKTTLSRF VAWMNGLSVF
QIKVHNKYTG EDFDEDLRSV LKRSGCKDEK IAFILDESNV LESGFLERMN TLLANGEVPG
LFEGDEYTTL ITQCKEGAQR EGLMLDSNEE LYKWFTGQVM KNLHVVFTMN PSSEGLKDRA
ATSPALFNRC VLNWFGDWSD GALYQVGMEF TNRIDLDRPT WTPPDTLPIT NHRLPAHPTH
REAVINAFVY VHETLHKANA RLTKRGGRTT TITPRHYLDF INHFVKLYNE KRSDLEEQQL
HLNVGLNKIA ETVEQVEEMQ KSLAVKSREL NEKNEAANAK LRQIVKDQHE AEKKKLQSEE
IQEALEKQTI QIAQKREDVM VDLAQVEPAV IDAQQAVKSI KKQYLVEIRS MANPPAIVKL
ALESICLLLG ENATDWKAIR AVIMRENFIN SIVQNFSTEG ITDEMREKMK IKYLSNPDYN
FEKVNRASLA CGPMVKWAIA QINYADMLKR VEPLRDELKS LEVQADENKN KYEEVKNLIS
QFEQSISSYK DEYALLISQA HAIKIDLENI QAKVDRSRAL LRSLAIESER WESTSETFKS
QMSSIIGDVL LSSAFLSYAG YFDQHYRQNL FTTWCHHLQQ AGIQFRLDIA RTEYLSNPDE
RLRWQANALP TDDLCTENAI MLKRFNRYPL IIDPSGQATE FIMNEFADRK ITKTSFLDDS
FRKNLESALR FGNPLLVQDV ENYDPILNPV LNRELRRTGG RVLITLGDQD IDLSPSFVIF
LSTRDPTVEF PPDICSRVTF VNFTVTRSSL QSQCLNQVLK AERPDIDEKR SDLLKLQGEF
HLRLRQLEKS LLQALNDAKG KILDDDSVIT TLETLKKEAE DISRKVEETD KVIAEIETVS
LQYLPLSQAC SNIYFTMDSL NQIHFLYQYS LKFFLEIFSS VLHNNSELAN LTDNAARLGV
ITKTLFSVCY ERVARGMLHA DRLTFALLLC RIHLKGVPNE SVFDEEFHFF LRGKEGMLDV
NPPAIEGLNQ EQLEAIMRIS TKLKPFRNIA KIITSMPEFG AWLQQSTPEQ NVPKLWENVT
LSDIGDAMYQ LLAIQTFRPD RVIAAATQFV SVVLGEDFMP MAEKELNLAE RWESELRANV
PILLCSVPGY DASGRVDDLA VELKVPLASI AIGSAEGFSQ AEKAINVAVK SGRWVLLKNV
HLAPQWLVQL EKKLHSIQPH SNFRLFLTME INLKLPVNLL RAGRIFVFEP PPGIRANLLR
TFSTVSAQRM MKAPSERARL YFLLAWFHAI VQERLRYAPL GWAKYYEFNE SDLRVACDTL
DTWIEATAMG RTNLPPEKVP WDALVTLLSQ CIYGGKIDND FDQRLLASFL AKLFTPKSFE
TDFALVANVD GVAGGPGGQR HITMPDGNRR DQFLQWIEAL SDRQTPSWLG LPNNAEKVLL
TTLGTDLVGK LLKMQQLEDD EELAYSPDES LDQTIVQDVD GRPSWMKTLH NSATTWLQLL
PKSLKTLRRT VENIKDPIYR YFEREVNLGS KLLSDVIHDL EDISLICRGD KKQTNYHRAM
LSDLVKGILP GHWRRYTVPR GCTVIQWITD FSQRIKQLQE VSKVVSNKGA KELKSFNVWL
GGLLNPEAYV TATRQSVAQA NGWSLEELVL DITISDGNDV NADDCSFAVI GLKLQGAQCR
NNQLHLTSAI MTELPMTLLR WVRASAVSNG KLSLPVYLNS TRTELLFTVD LNIAAGQERH
SFYERGVALL TSTALN
//