ID E0VBR8_PEDHC Unreviewed; 805 AA.
AC E0VBR8;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Histone acetyltransferase GCN5 {ECO:0000256|ARBA:ARBA00019713};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN Name=8231146 {ECO:0000313|EnsemblMetazoa:PHUM067370-PA};
GN ORFNames=Phum_PHUM067370 {ECO:0000313|EMBL:EEB10824.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB10824.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10824.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB10824.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10824.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM067370-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM067370-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. GCN5 subfamily.
CC {ECO:0000256|ARBA:ARBA00008607}.
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DR EMBL; AAZO01000785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235035; EEB10824.1; -; Genomic_DNA.
DR RefSeq; XP_002423562.1; XM_002423517.1.
DR AlphaFoldDB; E0VBR8; -.
DR STRING; 121224.E0VBR8; -.
DR EnsemblMetazoa; PHUM067370-RA; PHUM067370-PA; PHUM067370.
DR GeneID; 8231146; -.
DR KEGG; phu:Phum_PHUM067370; -.
DR CTD; 8231146; -.
DR VEuPathDB; VectorBase:PHUM067370; -.
DR eggNOG; KOG1472; Eukaryota.
DR HOGENOM; CLU_015901_0_0_1; -.
DR InParanoid; E0VBR8; -.
DR OMA; YFQTKMR; -.
DR OrthoDB; 1760108at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR037800; GCN5.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR009464; PCAF_N.
DR PANTHER; PTHR45750; GH11602P; 1.
DR PANTHER; PTHR45750:SF3; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF06466; PCAF_N; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 473..619
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
FT DOMAIN 713..783
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 805 AA; 92304 MW; 7A2BC5A2CC7959F3 CRC64;
MTDPNLSKNV SELAGVGSSG FSNQQPDESQ QQQPPDQVNQ KQSNLLRIQQ RKQQVYNWPN
HKKLLKLAVY SACQAEECLC TGWKTTPAPT QTLASNDTPC RNCTHILEQH ISHLRMVPDP
EINRLLGMVV DVENIYMSMQ KEEDPDTKRV YFYLFKLLRK CIVTMTKPTI EGPLGQPPFE
RPSIAKAVTN FVLHKFGHLA QREWQTMYEL AKMFLHCLNN WNYESPSIRR NVAAPEATSA
YKINYTRWLV FCHVPAFCDS LPHFDTTVVF GRKLLRAVYK SVCRQLIDKC HAERDRMQTE
NRILILTHFP KFLSLLEEEI YAPNSPIWDP EFRQVPPAHI QAVFDAKAAA AAAGRKVGEF
EKLTAPPNEK DNFTTFNVTP GVGRKGTSQK SDGEKRSGES TSGRPEKKRK QEEYVDDVSE
NTIAEILATI EDGKGNAGPQ AVFPENAPRD EAAKQEEARG IIQFQVVGNS LTQSVSKQTM
LWLIGLQNVF SHQLPRMPKE YITRLVFDPK HKTLALIKGG RAIGGICFRT FASQGFVEIV
FCAVTSNEQV KGYGTHLMNH LKDYFINHNI LHFLTFADEF AIGYFKKQGF SKDIKLNRNI
YQGYIKYYER ATLMHCQLNP TIVYTEFTAI IRKQKEIVKK IIEQRNQEVQ KVHQGLTCFK
EGVRGIPIEA IPGIRETGWK PAARTTRISR VTSEPNDPDT LCSALTGVYN AVKNQSHAWP
FLKPVDKNEV PDYYHHIKYP MDLKTMGERL RSGYYHSRRL FIADMTRVFT NCRLYNSPDT
EYYRCANNLE KYFQTKMKEI GLWDK
//
