ID E0VCE3_PEDHC Unreviewed; 1661 AA.
AC E0VCE3;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Low-density lipoprotein receptor, putative {ECO:0000313|EMBL:EEB11049.1, ECO:0000313|EnsemblMetazoa:PHUM086410-PA};
GN Name=8231533 {ECO:0000313|EnsemblMetazoa:PHUM086410-PA};
GN ORFNames=Phum_PHUM086410 {ECO:0000313|EMBL:EEB11049.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB11049.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB11049.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB11049.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB11049.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM086410-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM086410-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; AAZO01001032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235053; EEB11049.1; -; Genomic_DNA.
DR RefSeq; XP_002423787.1; XM_002423742.1.
DR STRING; 121224.E0VCE3; -.
DR EnsemblMetazoa; PHUM086410-RA; PHUM086410-PA; PHUM086410.
DR GeneID; 8231533; -.
DR KEGG; phu:Phum_PHUM086410; -.
DR CTD; 8231533; -.
DR VEuPathDB; VectorBase:PHUM086410; -.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_002489_0_0_1; -.
DR InParanoid; E0VCE3; -.
DR OMA; VNPCKVN; -.
DR OrthoDB; 3107655at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 10.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 19.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 14.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:EEB11049.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EEB11049.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1661
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011412345"
FT TRANSMEM 1446..1469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 64..109
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 110..152
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 153..198
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 199..241
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 291..329
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 377..419
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 420..462
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 463..507
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 508..550
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 598..636
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 682..724
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 725..767
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 768..810
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 811..852
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 900..939
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 986..1029
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1075..1117
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1481..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1518..1568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1518..1545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1627..1661
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1344..1359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1362..1374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1369..1387
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1381..1396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1661 AA; 187691 MW; 289C5AECB80A97F5 CRC64;
MIFFCRLFAL LSIFTIGKGY PHLLTYITSK DIRIVNVTKN NAKDTIIIRD LTEGAALDFC
YKAGLICWTD HMLEVIQCAN YNGTHATNKF SIVKTQVMSP DGIACDWVTQ KLYWTDGDTK
RIEVVSLVTR HRKVLFWDDI DQPRAIALVP MKKFMFWTDW GEVPKIERAD MDGSNDSRKV
IVSDDIFWPN GISVDYDNEV IYWVDGKLQF LAVVDYDGRN RRKILKTGME YPYGITSFQN
KIYWTDWKTW SIHELDRNNS NVSPKNILNS EYVPTDVRAY EPERQPSMDT PCNTNNGGCS
HLCLLSTNPS GYKCACPTGV KLINKYTCAN GSQEILIVVQ RNGINKISLD CPDYTTFKLP
LQGIRHAIAV DYDPVEDFIY WTDDNNKGIR RAKISGSQQE DIIITEVQHS DGIAVDWLSR
NLFWTDTGTD RIEVATLQGL YRKVLINKDL DEPRGIAVAP EHGLIFWSDW SKTKPKIERS
NMDGSDRRLL ISENLGWPNG IALDLTLEKL YWCDAQTDKI ESSSFDGTDR REIISDNLSH
PFGLSLLGDY LYWTDWSQRS IDRVNRFTSS NRQMIADQIV NIMDLKAVKL GYYKGKNLCS
VNNGGCNHLC LNRPNNNYTC DCQIDYELSS NMKTCVLPEA FLLFSRREAI GKISIENHNN
DLNLPIAGVK YASGLDFDKN DGRIYWADTK LKTITRSFIN GSDVEKIIEF GLDMPQSVAV
DWVSHNIYWI DSGNKRIEVA RTNGTSRRVL IWKDVEEPYN LVLDPKQGYM YWSDWSKMGT
IKRATMDGKN IIDLVTNVGR ANGLTIDDEY RKLYWTSNKP SIECSNLDGT SRRKIIKDNL
SKPIGLSQYQ DYIYWTDWET GAIEAANKTT GQNRTLIHSN LKDVSDILVY HKRRQSGWNQ
CAVNNGGCSH LCLPLPGDSY ACNCPMHYHL NTNTNKTCLK PKSFILFSQK NSIHRLVPDT
DDCPDVILPI QGVKNVRAIE FDPISQYLYW IDGRSQSIRR SDTESKTSTV FTITDKNFHP
YDLALDPYTR LLFWSCAISD VINVTRIDSP TVKVDSILKN ISHKPRNLAL HPEQGFLFWT
DLTSVHKVYR SRLDGSEKLL IANDLKDVTS IAVDRASNLL FFAYSFQIDV CNLDGHRRKT
LLNQVEVESL AIQKSMLYLV TKDNHVIEQI KIANELLKLN KHRRNVLTRV MPTDMVAVQM
PTLKMLKSHP CSAINKLGCS HICVIVDSRP FNSLHSRGGL YYNRSEYLSS YSHQLEIHNN
EFDESHNTLE DVDGRYDGVK NLDKFPMEQP SLYPLKSKCA CPIDQILTDD RTCSDLPSCG
ADHFTCLGMK KTGGKDCIPI DWRCDGQADC SDGSDETGCP NCGPNQFQCL SGHCIDSSFV
CDRQENCPDG SDEAKCCKEG EFQCVGSGRC IDQLSVCDGI NTCEDNSDEN PSACNIASIP
YADKNYTGYV LGVIVVFACA ISLIPLSIYC CRRKRNRIPD EVGDSAGDPL APKPFQSMKM
PKPTKIQDSV RMSMFNGSTT SNSYDRNHIT GASSSSTSNG MCSGANVYPA ETLNPPPSPA
TTTESRRCCS ASASRYRPYR HYRVINQPPP PTPCSTDVCD ESDYGYRPQT ESEYMTYSRG
TASECDGDPF PPPPTPSSCP PSPSSTYFNP LPPPPSPNRH H
//
