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Database: UniProt
Entry: E0VDN6_PEDHC
LinkDB: E0VDN6_PEDHC
Original site: E0VDN6_PEDHC 
ID   E0VDN6_PEDHC            Unreviewed;       439 AA.
AC   E0VDN6;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   08-MAY-2019, entry version 42.
DE   SubName: Full=Sphingomyelin phosphodiesterase, putative {ECO:0000313|EMBL:EEB11492.1, ECO:0000313|VectorBase:PHUM122240-PA};
DE            EC=3.1.4.12 {ECO:0000313|EMBL:EEB11492.1};
GN   Name=8238356 {ECO:0000313|VectorBase:PHUM122240-PA};
GN   ORFNames=Phum_PHUM122240 {ECO:0000313|EMBL:EEB11492.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura;
OC   Pediculidae; Pediculus.
OX   NCBI_TaxID=121224 {ECO:0000313|Proteomes:UP000009046};
RN   [1] {ECO:0000313|EMBL:EEB11492.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB11492.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB11492.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB11492.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000009046, ECO:0000313|VectorBase:PHUM122240-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USDA {ECO:0000313|Proteomes:UP000009046,
RC   ECO:0000313|VectorBase:PHUM122240-PA};
RX   PubMed=20566863; DOI=10.1073/pnas.1003379107;
RA   Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A.,
RA   Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E.,
RA   Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A.,
RA   Veenstra J.A., Walenz B., Tubio J.M., Ribeiro J.M., Rozas J.,
RA   Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L.,
RA   Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M.,
RA   Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P.,
RA   Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M.,
RA   Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F.,
RA   Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G.,
RA   Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C.,
RA   Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L.,
RA   Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C.,
RA   Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M.,
RA   Pittendrigh B.R.;
RT   "Genome sequences of the human body louse and its primary endosymbiont
RT   provide insights into the permanent parasitic lifestyle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010).
RN   [4] {ECO:0000313|VectorBase:PHUM122240-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|VectorBase:PHUM122240-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; DS235083; EEB11492.1; -; Genomic_DNA.
DR   RefSeq; XP_002424230.1; XM_002424185.1.
DR   STRING; 121225.PHUM122240-PA; -.
DR   EnsemblMetazoa; PHUM122240-RA; PHUM122240-PA; PHUM122240.
DR   GeneID; 8238356; -.
DR   KEGG; phu:Phum_PHUM122240; -.
DR   VectorBase; PHUM122240-RA; PHUM122240-PA; PHUM122240.
DR   CTD; 8238356; -.
DR   InParanoid; E0VDN6; -.
DR   KO; K12351; -.
DR   OMA; GGLIFMF; -.
DR   PhylomeDB; E0VDN6; -.
DR   Proteomes; UP000009046; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR038772; SMPD2-like.
DR   PANTHER; PTHR12393:SF7; PTHR12393:SF7; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009046};
KW   Hydrolase {ECO:0000313|EMBL:EEB11492.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    331    353       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    373    393       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       19    255       Endo/exonuclease/phosphatase.
FT                                {ECO:0000259|Pfam:PF03372}.
SQ   SEQUENCE   439 AA;  50491 MW;  A94B3427165B2ECA CRC64;
     MENFVTDKSN EKQQIRVFTL NCWGLPCFSK NKKCRITAIA EYLSSSDLDI VCLQEIWSKK
     DYLYISKKCF LQLPYSHYFN SFIIGSGLCI FSKHPISDVY FHQWPINGYA HKIHQGDWLA
     GKGVAFARIK IKDLVVNVYN AHLHAEYNIH GTEYLSHRVL QAFDTSQFIR LTIEDCDLAV
     LAGDLNTEPD DLAIKILNQN AQLTDCYFVA QKKTLTFFGT NESTRNSYAP KSEVKRLPQG
     KRIDYILYRN SRKINVEVQN YQFPLPEKVP GCTHSYSDHE GVEVLLQYGF DSALKGRGPE
     GNSYELQLTL ETAIDVCNDA LHKLRVAQKT YLTLSILFGV LIIVSWFAEL FFYIPLDIGG
     YQVASTKSNK YYILYKTYTL GYKLFFYFSL LFITIRNIKF FKCACVSGKV RSCPKLLLKC
     ISRIALEEVK NCLFQVLPL
//
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