ID E0VDY7_PEDHC Unreviewed; 692 AA.
AC E0VDY7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Cleavage and polyadenylation specificity factor 73 kDa subunit, putative {ECO:0000313|EMBL:EEB11593.1};
GN Name=8239346 {ECO:0000313|EnsemblMetazoa:PHUM126840-PA};
GN ORFNames=Phum_PHUM126840 {ECO:0000313|EMBL:EEB11593.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB11593.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB11593.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB11593.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB11593.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM126840-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM126840-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AAZO01001486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235088; EEB11593.1; -; Genomic_DNA.
DR RefSeq; XP_002424331.1; XM_002424286.1.
DR AlphaFoldDB; E0VDY7; -.
DR STRING; 121224.E0VDY7; -.
DR EnsemblMetazoa; PHUM126840-RA; PHUM126840-PA; PHUM126840.
DR GeneID; 8239346; -.
DR KEGG; phu:Phum_PHUM126840; -.
DR CTD; 8239346; -.
DR VEuPathDB; VectorBase:PHUM126840; -.
DR eggNOG; KOG1137; Eukaryota.
DR HOGENOM; CLU_009673_2_3_1; -.
DR InParanoid; E0VDY7; -.
DR OMA; CKQHITL; -.
DR OrthoDB; 169081at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0031123; P:RNA 3'-end processing; IEA:UniProt.
DR CDD; cd16292; CPSF3-like_MBL-fold; 1.
DR Gene3D; 3.40.50.10890; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR021718; CPSF73-100_C.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR011108; RMMBL.
DR PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11203:SF11; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3; 1.
DR Pfam; PF10996; Beta-Casp; 1.
DR Pfam; PF11718; CPSF73-100_C; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR Pfam; PF07521; RMMBL; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SMART; SM01098; CPSF73-100_C; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 32..242
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT DOMAIN 254..375
FT /note="Beta-Casp"
FT /evidence="ECO:0000259|SMART:SM01027"
FT DOMAIN 485..685
FT /note="Pre-mRNA 3'-end-processing endonuclease
FT polyadenylation factor C-term"
FT /evidence="ECO:0000259|SMART:SM01098"
SQ SEQUENCE 692 AA; 78473 MW; D49B36CD0D88E6D4 CRC64;
MLSSGKKTEP QAPSEENDLL RIRPLGAGQE VGRSCIMLEF KGKNVMLDCG IHPGLSGLDA
LPFVDLIEAD EIDLLLVTHF HLDHSGALPW FLLKTKFKGR CFMTHATKAI YRWLLSDYIK
VSNISTEQML YTDHDLEESM EKIETINFHE EKEIFGIKFW AYHAGHVLGA AMFMIEIAGV
RVLYTGDFSR QEDRHLMAAE IPSIKPDVLI TESTYGTHIH EKREERETRF TNLIHTIINR
GGRCLIPVFA LGRAQELLLI LDDYWSQHPE LHDIPIYYAS SLAKKCMAVY QTYVNAMNDK
IRRQIAINNP FIFRHIHNLK GIDHFDDIGP CVVMASPGMM QSGLSRELFE LWCTDSKNGV
IIAGYCVEGT LAKQILSEPE EIVTLSGQKL PLKMSVDYIS FSAHTDYKQT SEFVRALKPP
HVVLVHGEQN EMNRLKAALK REYEDDPNTS IEIHNPRNTT AVELYFRGEK TVKVMGALAM
QKPQPGDKVS GILVKRNFNY HLLAPFDVPK YTDMTITKVT ERVSVYYSGQ VSILKYLLNQ
SCGPVEVVDE KKLKIFKTIN VNIDNKIITL EWVASPVNDM YANAIVSTIL QADSLQDDSK
KNVPIPSAKM DLMHFKECLI EMLQEMFGED SVPKIFKGEK LYVTVDGKKA NVDFSKLTVV
CEEDPVFQQM VQTAVTKLYQ SLSPPKVDEG LK
//
