ID E0VEC5_PEDHC Unreviewed; 318 AA.
AC E0VEC5;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 08-NOV-2023, entry version 61.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=8234091 {ECO:0000313|EnsemblMetazoa:PHUM130730-PA};
GN ORFNames=Phum_PHUM130730 {ECO:0000313|EMBL:EEB11731.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB11731.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB11731.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB11731.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB11731.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM130730-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM130730-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AAZO01001515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235090; EEB11731.1; -; Genomic_DNA.
DR RefSeq; XP_002424469.1; XM_002424424.1.
DR AlphaFoldDB; E0VEC5; -.
DR STRING; 121224.E0VEC5; -.
DR EnsemblMetazoa; PHUM130730-RA; PHUM130730-PA; PHUM130730.
DR GeneID; 8234091; -.
DR KEGG; phu:Phum_PHUM130730; -.
DR CTD; 8234091; -.
DR VEuPathDB; VectorBase:PHUM130730; -.
DR eggNOG; KOG2935; Eukaryota.
DR HOGENOM; CLU_031228_2_0_1; -.
DR InParanoid; E0VEC5; -.
DR OMA; WGLEIIH; -.
DR OrthoDB; 337428at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.90.70.40; -; 1.
DR Gene3D; 1.10.287.10; S15/NS1, RNA-binding; 1.
DR InterPro; IPR033865; Ataxin-3.
DR InterPro; IPR006155; Josephin.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR14159; ATAXIN-3-RELATED; 1.
DR PANTHER; PTHR14159:SF0; ATAXIN-3-RELATED; 1.
DR Pfam; PF02099; Josephin; 1.
DR Pfam; PF02809; UIM; 2.
DR PRINTS; PR01233; JOSEPHIN.
DR SMART; SM01246; Josephin; 1.
DR PROSITE; PS50957; JOSEPHIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00331}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 41..222
FT /note="Josephin"
FT /evidence="ECO:0000259|PROSITE:PS50957"
FT REGION 295..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 54
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"
FT ACT_SITE 54
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR633865-1"
FT ACT_SITE 161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"
FT ACT_SITE 161
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR633865-1"
FT ACT_SITE 176
FT /evidence="ECO:0000256|PIRSR:PIRSR633865-1,
FT ECO:0000256|PROSITE-ProRule:PRU00331"
SQ SEQUENCE 318 AA; 36065 MW; A3227E02DEB1EE3B CRC64;
MLDVMIFQAE SKMNFFLTCV TFFKYPFDIE RANNYVIKTN MESIYFEKQE GSLCAQHCLN
ALLQGPYFTA VDLAMHAQNL DDEERIRMAE SGIDSIEYRN FLEQPSGNMD DSGYFSVQVI
SSCLSVWGLE LVRYGSTEKK ALEAKQNPEL MKAYICNYKD HWFTVRKLAH QWFNLNSLSS
GPKLISNTYL GMFLAQLQQE GYSIFVVLGD FPQCEADLVL KVKPVSQTNV DNPGPSTKNS
GHQIKPFQGV GYQLGTSNQV KPYDSNDDLQ RALQLSLTAE DNQTEDVEMK RAIELSLRAT
TSSHSLGNES NEKQKTKK
//
