GenomeNet

Database: UniProt
Entry: E0VEK3_PEDHC
LinkDB: E0VEK3_PEDHC
Original site: E0VEK3_PEDHC 
ID   E0VEK3_PEDHC            Unreviewed;      5058 AA.
AC   E0VEK3;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   07-NOV-2018, entry version 56.
DE   SubName: Full=Ryanodine receptor, putative {ECO:0000313|EMBL:EEB11809.1, ECO:0000313|VectorBase:PHUM135890-PA};
GN   Name=8234224 {ECO:0000313|VectorBase:PHUM135890-PA};
GN   ORFNames=Phum_PHUM135890 {ECO:0000313|EMBL:EEB11809.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura;
OC   Pediculidae; Pediculus.
OX   NCBI_TaxID=121224 {ECO:0000313|Proteomes:UP000009046};
RN   [1] {ECO:0000313|EMBL:EEB11809.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB11809.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB11809.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB11809.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000009046, ECO:0000313|VectorBase:PHUM135890-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USDA {ECO:0000313|Proteomes:UP000009046,
RC   ECO:0000313|VectorBase:PHUM135890-PA};
RX   PubMed=20566863; DOI=10.1073/pnas.1003379107;
RA   Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A.,
RA   Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E.,
RA   Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A.,
RA   Veenstra J.A., Walenz B., Tubio J.M., Ribeiro J.M., Rozas J.,
RA   Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L.,
RA   Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M.,
RA   Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P.,
RA   Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M.,
RA   Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F.,
RA   Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G.,
RA   Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C.,
RA   Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L.,
RA   Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C.,
RA   Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M.,
RA   Pittendrigh B.R.;
RT   "Genome sequences of the human body louse and its primary endosymbiont
RT   provide insights into the permanent parasitic lifestyle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010).
RN   [4] {ECO:0000313|VectorBase:PHUM135890-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|VectorBase:PHUM135890-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; DS235093; EEB11809.1; -; Genomic_DNA.
DR   RefSeq; XP_002424547.1; XM_002424502.1.
DR   STRING; 121225.PHUM135890-PA; -.
DR   EnsemblMetazoa; PHUM135890-RA; PHUM135890-PA; PHUM135890.
DR   GeneID; 8234224; -.
DR   KEGG; phu:Phum_PHUM135890; -.
DR   VectorBase; PHUM135890-RA; PHUM135890-PA; PHUM135890.
DR   CTD; 8234224; -.
DR   InParanoid; E0VEK3; -.
DR   KO; K04962; -.
DR   OMA; PLLNEYC; -.
DR   PhylomeDB; E0VEK3; -.
DR   Proteomes; UP000009046; Partially assembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009046};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EEB11809.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4404   4424       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4583   4602       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4664   4686       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4795   4819       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4857   4877       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4931   4954       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    148       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      155    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      575    800       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1029   1212       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1433   1652       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4152   4178       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4156   4167       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED      453    480       {ECO:0000256|SAM:Coils}.
FT   COILED     1407   1427       {ECO:0000256|SAM:Coils}.
FT   COILED     3752   3772       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5058 AA;  574332 MW;  EB84289834697C35 CRC64;
     MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNIPPDLS
     QCVFVIEQAL SVRALQELVT AAGSESGKGT GSGHRTLLYG NAILLRHQNS DMYLACLSTC
     SSQDKLSFDV GLQDHSLGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE
     NDLSIVNASF HVTHWSVQPY GTGVSRMKYV GYVFGGDVLR FFHGGDECLT IPSTWSEEPG
     QNMVVYEGGS VMSQARSLWR LELARTKWSG GFINWYHPMR IRHITTGRYL GVNENNELYL
     VNREEATTSL STFCLRQEKD DQKVVLEDKD LEVIGAPIIK YGDSTVIMQH SETGLWVSYK
     SFETKKKGVG KVEEKQAILH EEGKMDDGLD FSRSQEEESR TARVIRKCSS LFTGSIKSLE
     NIQATRRTSS FFATVNLTEI VMCLEDLINY FEQPEEEMEH EEKQNKLKAL RNRQDLFQEE
     GILNLILEAI DKINIITGQG FLVALPGEIG QNWEAISSYL YQLLAAIIKG NHTNCKEFAN
     TNRLNWLFSR LGSQASGEGT GMLDVLHCVL IDSPEALNMM KDEHIKVIIS LLEKHGRDPK
     VLDVLCSLCV GNGVAVRSSQ NNICDFLLPG KNLLLQTQLV DHVASVRPNI FVGRVENSAV
     YQKWYFEVTL DHIEQTTHLK PHLRIGWANT SGYVPYPGGG EKWGGNGVGD DLYSYGFDGA
     NLWTGGRKTE VVPEATEPYI KKGDIIGVAL DLNVPIITFT MNGVQINATF KDFNLDGMFF
     PVISCSSKLS CRFLLGGDHG KLKYIPPEEF SPLIECLMPQ QVLSIDPCFY FGNLNKNVLA
     GPWLVEGDTA FVPNPVDTST ITLPSYIENI RDKLAENIHE MWAMNKIEAG WIFGEIRDDV
     RKIHPCLTQF EKLPPAEKRY DSQLAIQTLK TILALGYYIT MDKPPSRIKQ IRLPNETFLQ
     PNGYKPAPLD LSAVALSIKM EELVDHLAEN THNLWAKERI QQGWTYGLNE DPDLLRSPHL
     VPYIKVDDAI KKANRDTASE TVRTLLVYGY NLDPPTGEQQ EALLAEANKS REQDFRTYRV
     EKNYAVSNGK WYFEFEILSS GPMRVGWARA DCPPGNKLGS DEYTWAFDGF NEEKVFCGSG
     ESFGKQWKIG DVVGVFLDLL DRTISFSLNG ELLMDALGGE TTFAEVQGDS FIPACTLGIG
     QKARLTFGQD VNTLQYFSNC GLQEGYEPFC VNMNRPVTYW YTKDQPIFEN TDESSDSMID
     VLRIPAGSDS PPCLKISHNM FETMEKANWE FLRLSLPVIC QSTLIDEEEK NKRWQEIKSR
     QRRLLTESEH PTPAHIEQIM KSGFSINDIK GLARGYSEDA VEADEMLLNR PDIQNQGHSP
     KPSRKGSLTR FEGRNHGGTM GSRKNNRSNS EIDINKLENE EKDKKTRGRS PFRFFSRRKD
     GDRQRKNRTP EPGSPDYDHL SPPQIRISKA DGKDSMAGDR NVNLQDKMSP GVDSVGNEPF
     DVECLKLINE YFYGVRIFPG QDPSHVYVGW VTTQYHYFSN EFNQTKVRKA SITKIDDFNN
     VKERIDRQSC YMVKASELYN EVSSDTSGKG ASQGMFIGCF VDTATGFITY TCEGKETSHK
     YKMEPETKLF PAIFVEATSK EILQVELGRT SSTLPLSAAV LMNSERHITP QFPPRLKVQC
     LKPNQWARVP NQSLQVHALK LSDIRGWSML CEDPISMLAV HIPEEDRCID VLELIEMERL
     LSFHAHTLTL YSALCYQSNY RAAHILCQHV DERQLLYAIK SAYMSGPLRR GFYDLLISLH
     LESHATTMEV SKNEYVIPLS QELKELYRDS DMYHSLSSLN MESVRPKMKM TDSSEQVENI
     RELYSPYFPL NVVRDFVMQA LEEAVEVNQV HNRDPIGGSN ENLFLPLLKL VDRLLLVEVL
     RDEDLKKLLI MMDPETWDET FDKSGKDEHR KGLLHMKMAE GAKLQMCYVL HHFGDIQLRH
     RVESLIAFSA EFVGELQQDQ LRRYTEIKQS DLPSAIAAKK TREFRCPPRE QMNAILGFKN
     LEDDDVENCP CGIELREKLN VFHSKLMSQV SLTALQEPLE SEDEETSDKP TTMKKLYSLI
     HAVKELEETP EPSEEPQKKS PEAIFRKVLI STIVRWAEES QIETSKLVRE MFSLLVRQYD
     SVGELIKALG KTYVTNAKTR DDAALMWVGL SQIRSLLPVQ MSQEEEGLLR ERLWKLVNNH
     TFFQHPDLIR VLRIHENVMA VMMNTLGRRA QTQSDTPQTT DQGEAVPKEK DTSHEMVVAC
     CRFLCYFCRT SRQNQKAMFD HLAFLLENSN ILLSRPSLRG STPLDVAYSS VMENTELALA
     LREHYLEKIA VYLSRCGLQS NSDLVEKGYP DLGWDPVEGE RYLDFLRFCV WVNGESVEEN
     ANLVIRLLIR RPECLGPALR GEGEGLLRAI VDANQMSEKI SDRRKLMDEA EGTMAMSDFQ
     HPLPESDEDE DYIDTGAAIL AFYCTLVDLL GRCAPDSTVI ALNKNESIRA RAILRSLVPL
     EDLQGVLALR FTLQQPAAGE ERAKSDMPSG LIPGHKQSIV MFLERVYGIE TQELFFRLLE
     DAFLPDLRCA TMLDRSDGSE SEMALAMNRY MGNSVLPLLI KHAKFYSEAD NYASLLDATL
     HTVYRLSKNR MLTKGQRESV SDFLVALTSQ MQPSMLLKLL RKLTVDVSNL SEYTTVALRL
     LTLHYDRCAK YYGSSSGQQS LYGASSDEEK RLTMVLFSNI FDSLSKMDYD PDLFGKALPC
     LAAIGCALPP DYTLSKTFDD EIYERGGAGE RGSYTPQPIN TASIVLNTDL NSIVQKFSEH
     YHDAWASRKL ENGWTYGETW SDTNKTHPRL KPYSMLNDYE KERYKEPVRE SLKALLAIGW
     NVEHTEVDIP SSHRASMRRQ SKPTSAESST PFNYHPHPVD MTNLTLNKEM QNMAERLAEN
     AHDIWAKKKK EELTACGGVV HPQLVPYDLL TDKEKRKDRE RSQEFLKYLQ YQGYKLHRPY
     KGGETEQAAA LSSVENRFAY SLLEKLIQYT DKAAINMKLL KPSSTFSRRT SFKTCSRDIK
     FFSKVVLPLI EKYFNTHKNY FIAVATASNN VGAASLKEKE MVASLFCKLA NLLRIRLTSF
     GSDVRITVRC LQVLVKGVDA KSLVKNCPEF IRTSMLTFFN NTADDLSHTI LNLHEGKYSH
     LRGTHLKTCT SLTYVYSVVL PVLTSMFDHL ASCEYGSDLL LDEIQVAAYK ILGSLYTLGI
     DGTLHGDRKY LKTEIDRHRP ALGNCLGAFS STFPVAFLEP HLNKHNQYSL LNRIADHSLE
     AQDVMARMEQ SMPSLEAILS DVDAFVESDK THTDSPHIID VVLPLLCSYL PFWWSQGPDN
     VNPQGGNHVT MITAEHMNQL LKSVLNLIKK NIGNENAPWM TRIATYTQQI IINSSEELLK
     DPFLPLAERV RKRTENMFHK EESLRGFIKS SSDDTSQVEA QIQEDWQLLV RDIYAFYPLL
     IKYVDLQRNH WLRNNISEAE DLYKHVAEIF NMWSKSQYFL KEEQNFIAAN EIDNMILIMP
     TATRRTAVSS ESGTPSSGNK KKKKKHREKK RDKDKEIQAS LMVACLKRLL PVGLNLFAGR
     EQELVQHCKD RYLKKLPENE ISDFAKTQLT LPDKIDPADE MSWQHYLYSK LGSKKEVAVE
     VKDKDKQIEE LVCRIVAMAK VLYGLHMIDH PQQQGKAVYR SVVSTQRKRA VLSCFRQASL
     HSLPRHRSIN IFVKTYFEQW LQDENTGQEV MIEDLTQSFE DAELKKNDKN EDEAKPDPLT
     QLVTTFCRGA MTERSGALQE DPLYMSYADI ASKSCGEEEE EGGDEEEEGG GSSIHEQEME
     KQKLLFHQAR LANRGVAEMI LLHISACKGI PSDMVMKTLQ LGISILRGGN IEIQMGMLNH
     LKEKKDVGFF TSIAGLMNSC SVLDLDAFER NTKAEGLGVG SEGAAGEKNM HDADFICALF
     RFIQLTCEGH NLEWQNYLRT QAGNTTTVNV VICTVDYLLR LQESIMDFYW HYSSKELIDP
     AGKANFFKAI GVASQVFNTL SEVIQGPCTQ NQQALAHSRL WDAVGGFFFL FSHMQEKLSK
     HSSQVDLLKE LLNLQKDMIT MMLSMLEGNV VNGTIGKQMV DTLVESASNV ELILKYFDMF
     LKLKVLTETP SFKEIDYNND GWITPKDFKE KMEQQKSYAP EEIEFMLMCC ETNHDGKIDY
     VTFTEKFYEP AKENGFNLAV MLTNLSEHMP NEPRLARFLE TAGSVLSYFE PFLGRIEILG
     GSKRIERVYF EIQESNIEQW EKPQIKESKR AFFYSIVTEG GDKEKLEAFV NFCEDAIFEM
     THASALMDVE DSSGSGKARE AAYRYVADDE EERLAKDPVK RSIVYVKSGI SNAFQFFSPS
     NIKRNISDFQ QKPPLEQIKC FLKFFFYIFY YSGYGFASVI KYFLGMIMNL MRGPKEEATE
     EVVEEKEDFG PLKPLGVPSL TGEETGSLAI SHKDDNNKSD NLSSTSPSTG EENDENTTEE
     GQDSPKEEQL TLQDLLGGDI AKKEAVLTAE AQSQQQAVMA AVESEAKQNA TVGEPAAVSQ
     IDFNAYGHRA VSFLARNFYN LKYVALVLAF CINFILLLYK VTNVEGENDS KSSNEAASSL
     NDVFSGEKGD NFGSEEGGNE SGEDEGEDIE IVHVSEDYFY MAHVLRLMAM LHSLVSLAML
     IAYYHLKVPL AIFKREKEIA RRLEFDGLYI AEQPEDDDIK SHWDKLVISA KSFPVNYWDK
     FVKKKVRQKY SETYDFDSIS NLLGMERTSF SAQENGKTGS GIIHFVMNID WRYQVWKAGV
     TITDHAFLYS LWYFVFSVFG NFNNFFFAAH LLDVAVGFKT LRTILQSVTH NGKQLILTVM
     LLTIIVYIYT VIAFNFFRKF YVQEEDDEVD KKCHNMLTCF VFHLYKGVRA GGGIGDEIEP
     PDGDEYEVYR ILFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQLESVKED MESNCFICGI
     GKDYFDKVPH GFDTHVAQEH NLANYMFFLM HLINKPDTEY TGQETYVWNM YQQRCWDFFP
     VGDCFRKQYE DELGGGNN
//
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