ID E0VEM0_PEDHC Unreviewed; 366 AA.
AC E0VEM0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=Transcription factor Dp-2, putative {ECO:0000313|EMBL:EEB11826.1, ECO:0000313|EnsemblMetazoa:PHUM136260-PA};
GN Name=8234241 {ECO:0000313|EnsemblMetazoa:PHUM136260-PA};
GN ORFNames=Phum_PHUM136260 {ECO:0000313|EMBL:EEB11826.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB11826.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB11826.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB11826.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB11826.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM136260-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM136260-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR EMBL; AAZO01001576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01001577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235093; EEB11826.1; -; Genomic_DNA.
DR RefSeq; XP_002424564.1; XM_002424519.1.
DR AlphaFoldDB; E0VEM0; -.
DR STRING; 121224.E0VEM0; -.
DR EnsemblMetazoa; PHUM136260-RA; PHUM136260-PA; PHUM136260.
DR GeneID; 8234241; -.
DR KEGG; phu:Phum_PHUM136260; -.
DR CTD; 8234241; -.
DR VEuPathDB; VectorBase:PHUM136260; -.
DR eggNOG; KOG2829; Eukaryota.
DR HOGENOM; CLU_757167_0_0_1; -.
DR InParanoid; E0VEM0; -.
DR OrthoDB; 1343784at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd14458; DP_DD; 1.
DR Gene3D; 1.20.140.80; Transcription factor DP; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR038168; TF_DP_C_sf.
DR InterPro; IPR014889; Transc_factor_DP_C.
DR InterPro; IPR015648; Transcrpt_fac_DP.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12548; TRANSCRIPTION FACTOR DP; 1.
DR PANTHER; PTHR12548:SF9; TRANSCRIPTION FACTOR DP; 1.
DR Pfam; PF08781; DP; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01138; DP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transcription {ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 158..239
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 249..363
FT /note="Transcription factor DP C-terminal"
FT /evidence="ECO:0000259|SMART:SM01138"
FT REGION 323..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 242..269
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 323..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 40901 MW; 32609F064BED726B CRC64;
MVASQPQVIK VLHTGSGKGS KFTPGKSVIR SSIFKTNVPA TPVRKIFLED DNMVGTNSPT
LVKTRYGSTP TQSSTIKVFN GSSGSITQKT VQLTATQLAI SSQANNINKP SQSQSFGCQG
KILAKSTFNS TNKKNISINT DSDISLSMTD YKRRRADKLG KGLRHFSMKV CEKVRQKGTT
SYNEVADELV AEFTGTPYKP NQEQNYDQKN IRRRVYDALN VLMAMNIISK EKKEIRWIGL
PSTILEADKD SEREKKERLE RISQKTQDLH NLILQQIAFK NLVERNKKLE KKSGRPAQTT
AVELPFLVVN TSRETMVNCS VSNDKSDIEE NSGDLSVQNY SNPSEFLEEY LEDSDIASDP
ETDVQL
//
