ID E0VH11_PEDHC Unreviewed; 828 AA.
AC E0VH11;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=8240327 {ECO:0000313|EnsemblMetazoa:PHUM196820-PA};
GN ORFNames=Phum_PHUM196820 {ECO:0000313|EMBL:EEB12667.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB12667.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB12667.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB12667.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB12667.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM196820-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM196820-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; AAZO01002282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01002283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235156; EEB12667.1; -; Genomic_DNA.
DR RefSeq; XP_002425405.1; XM_002425360.1.
DR AlphaFoldDB; E0VH11; -.
DR STRING; 121224.E0VH11; -.
DR EnsemblMetazoa; PHUM196820-RA; PHUM196820-PA; PHUM196820.
DR GeneID; 8240327; -.
DR KEGG; phu:Phum_PHUM196820; -.
DR CTD; 8240327; -.
DR VEuPathDB; VectorBase:PHUM196820; -.
DR eggNOG; KOG4270; Eukaryota.
DR HOGENOM; CLU_014834_0_0_1; -.
DR InParanoid; E0VH11; -.
DR OMA; RESELCY; -.
DR OrthoDB; 7959at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF14; RHO GTPASE-ACTIVATING PROTEIN 92B; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 1..181
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 187..378
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 423..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 828 AA; 92399 MW; DFF6E6829BC63000 CRC64;
MTKKSPSYQL GAALLESSGA CDEESLMKVV LTKCGHAEKC ISEESAEHDS RVEQHVISPL
QNVIEVDFPN IVKQKRNVTK VCLDMDSAKT RYLQAQKHNS HTSGAAKVEL IKDELKDSEQ
KVEQSRDVLA CEMFHLAARE SELCYTVLQY YKFQKRYHEY ALGILDKLIP ELESDICSSK
TKPVYGVDLE EHLQVTGRKI AFPIELCVCA LLELGMEEEG LFRLAGGASK LKRMKLSFDA
GCMTLATALT YRDPHVIAGA LKSYLRELPE PLLTHSLYDE WLNAAKAQTH PDNKLQALWT
VVHKLPKPNF DNLSYLIKFF HILSKNHEIN KMSPHNIAIV IAPSLIWTKD ENGFGLNVNV
SLYPSIIDLL VTYADWFFDK EMDFYLTLEP IMNGEVEEKS SEKGIDNKGF DLKLADKMNK
SAIEKNSGQN HPGGDYDSNT SEMSRSQSTT CLSEETQAYE SPKPITRRKN KSIAPGPPIC
KDEKRKDGQL GKDNVKTKEI HVFNDKPDKP PRPTVVSNST LPRPSKSNRE NKINENNEEI
MKKQPVDDIV LSKKLDESNE KAFKMNRTSM DPNNFRNNYE NILLSSNENL NTGSTDDNRT
LQKNYSVINK QQQISVIEVG SSNKNNSNNK VSDNNTSGVV DDDADLIPSG RTTSMEKTVN
DNKTFESEVD KDADADDDDD KDVVVVQERK TAAVTSNRPL SLPGSEKPER PPKPDYKFSS
PPSSHTRTFS DGQIIDMKPS DNTSNNNNNN NGNVNISTNM SSGNSHCIKQ FTSSTNTTSE
TPSPTPPLSM SSSPPVSSIF IKHPQTSPPP PPVPAKPRAN SQSESTDF
//
