ID E0VHW9_PEDHC Unreviewed; 322 AA.
AC E0VHW9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=Ketimine reductase mu-crystallin {ECO:0000256|ARBA:ARBA00015173};
DE EC=1.5.1.25 {ECO:0000256|ARBA:ARBA00012883};
DE AltName: Full=NADP-regulated thyroid-hormone-binding protein {ECO:0000256|ARBA:ARBA00033420};
GN Name=8237519 {ECO:0000313|EnsemblMetazoa:PHUM216920-PA};
GN ORFNames=Phum_PHUM216920 {ECO:0000313|EMBL:EEB12975.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB12975.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB12975.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB12975.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB12975.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM216920-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM216920-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4-
CC dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:12504, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58517, ChEBI:CHEBI:176873;
CC EC=1.5.1.25; Evidence={ECO:0000256|ARBA:ARBA00029290};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-
CC dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH;
CC Xref=Rhea:RHEA:12500, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:58517, ChEBI:CHEBI:176873;
CC EC=1.5.1.25; Evidence={ECO:0000256|ARBA:ARBA00029330};
CC -!- SIMILARITY: Belongs to the ornithine cyclodeaminase/mu-crystallin
CC family. {ECO:0000256|ARBA:ARBA00008903}.
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DR EMBL; AAZO01002493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235172; EEB12975.1; -; Genomic_DNA.
DR RefSeq; XP_002425713.1; XM_002425668.1.
DR AlphaFoldDB; E0VHW9; -.
DR STRING; 121224.E0VHW9; -.
DR EnsemblMetazoa; PHUM216920-RA; PHUM216920-PA; PHUM216920.
DR GeneID; 8237519; -.
DR KEGG; phu:Phum_PHUM216920; -.
DR CTD; 8237519; -.
DR VEuPathDB; VectorBase:PHUM216920; -.
DR eggNOG; KOG3007; Eukaryota.
DR HOGENOM; CLU_042088_1_1_1; -.
DR InParanoid; E0VHW9; -.
DR OMA; AVKAFTY; -.
DR OrthoDB; 2501268at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0047127; F:thiomorpholine-carboxylate dehydrogenase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1780.10; ornithine cyclodeaminase, domain 1; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003462; ODC_Mu_crystall.
DR InterPro; IPR023401; ODC_N.
DR PANTHER; PTHR13812; KETIMINE REDUCTASE MU-CRYSTALLIN; 1.
DR PANTHER; PTHR13812:SF19; KETIMINE REDUCTASE MU-CRYSTALLIN; 1.
DR Pfam; PF02423; OCD_Mu_crystall; 1.
DR PIRSF; PIRSF001439; CryM; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:EEB12975.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
SQ SEQUENCE 322 AA; 35889 MW; EB723F89E76DF8C5 CRC64;
MQKRPVLVTE DDVKSLIEWN PLFDAIKGVM MDVSLKSNST DNLIVQPARS FMKIPHKNAV
MLMMPGLSER NKVLSCKIVT SFVDNPSKYN LPSIMANVFV FDTHTGKLKA VLEGTTITEW
RTAAASAVAT HYLKPEAGKN ETLAVIGAGA QGRIHIIAFK HFFNFKKVNL WNRTHSKALK
LAEDLKNQYD IDIEVFDNID DCVRDADVIV TATYSSNPLL KLNQIKKNVI INAIGAGIKH
HCELDDSIYE KSSIYTDSME NARVELKGLI EEGYPVLGEI GEIIIGKKEI VKNDVIIFHS
LGMGLEDGVT ARLILEKYSK NN
//
