ID E0VL44_PEDHC Unreviewed; 592 AA.
AC E0VL44;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
GN Name=8229460 {ECO:0000313|EnsemblMetazoa:PHUM280780-PA};
GN ORFNames=Phum_PHUM280780 {ECO:0000313|EMBL:EEB14100.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB14100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14100.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB14100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14100.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM280780-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM280780-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR EMBL; AAZO01003264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235269; EEB14100.1; -; Genomic_DNA.
DR RefSeq; XP_002426838.1; XM_002426793.1.
DR AlphaFoldDB; E0VL44; -.
DR STRING; 121224.E0VL44; -.
DR EnsemblMetazoa; PHUM280780-RA; PHUM280780-PA; PHUM280780.
DR GeneID; 8229460; -.
DR KEGG; phu:Phum_PHUM280780; -.
DR CTD; 8229460; -.
DR VEuPathDB; VectorBase:PHUM280780; -.
DR eggNOG; ENOG502QQHE; Eukaryota.
DR HOGENOM; CLU_017000_1_1_1; -.
DR InParanoid; E0VL44; -.
DR OMA; FLRTIDM; -.
DR OrthoDB; 3030146at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd11564; FAT-like_CAS_C; 1.
DR CDD; cd11549; Serine_rich_CAS; 1.
DR CDD; cd11844; SH3_CAS; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR014928; Serine_rich_dom.
DR InterPro; IPR038319; Serine_rich_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR PANTHER; PTHR10654:SF18; IP17195P; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF08824; Serine_rich; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..72
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 143..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 65816 MW; 571BEEF329028576 CRC64;
MISFQDAGDY QNCVAKALYD NIAESPDELA FRKGDLLTVL EQNTGGIEGW WLCSLRGRQG
ICPGNRLRIL PGFYDIGTAD LPIQNLSKRR SWHVQPNMVL TPQKFGDIYL YNLPAGSQCQ
KYDIPPPLQD SLLQAYDVPR ALSRESTEST LSTPKRSVPP VPQFESDSRE PDSQFYDIPR
PLLANSQPLT PSSSASSLTA PESLSLPSSN RSSLLSGPEY DIPKSRLSSS QLYDVPAPNP
KPKELPLELN SALETLNRLQ NEASGAVQRL LGLLSPGWRR LDNLQNRIFD IKLAAERLRT
SLHELSEFCE GSLGNAYKAA DKNLVIKLKP LAKALRDADK IVQETCNELD VMNWSIQDLS
RDSDQDSSLD NLDRLIACAK SLTEDIRRAA SSLQGNAPLL FKRDSSGTLP EDYDYVNLES
KDSIESEISQ ALPTELKKSY NAILRDAENN SLLVEDCNDE ENDDARLIRF YAALTVSHTA
QLTRAIDAFL QTVEHNQPPK IFLAHGKFVV LSAHRLVHVG DTVARNVSQA HIKQRIQERA
DGLSEALDQT VQRTKRAAQH FPNVAAVQDM VDAIVDVSHF ARDLKMSLVM AM
//
