ID E0VLF5_PEDHC Unreviewed; 501 AA.
AC E0VLF5;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Beta-amyloid-like protein {ECO:0008006|Google:ProtNLM};
GN Name=8229573 {ECO:0000313|EnsemblMetazoa:PHUM287170-PA};
GN ORFNames=Phum_PHUM287170 {ECO:0000313|EMBL:EEB14211.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB14211.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14211.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB14211.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14211.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM287170-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM287170-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the APP family. {ECO:0000256|PROSITE-
CC ProRule:PRU01217}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01217}.
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DR EMBL; AAZO01003334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235271; EEB14211.1; -; Genomic_DNA.
DR RefSeq; XP_002426949.1; XM_002426904.1.
DR AlphaFoldDB; E0VLF5; -.
DR STRING; 121224.E0VLF5; -.
DR EnsemblMetazoa; PHUM287170-RA; PHUM287170-PA; PHUM287170.
DR GeneID; 8229573; -.
DR KEGG; phu:Phum_PHUM287170; -.
DR CTD; 8229573; -.
DR VEuPathDB; VectorBase:PHUM287170; -.
DR eggNOG; KOG3540; Eukaryota.
DR HOGENOM; CLU_014607_2_0_1; -.
DR InParanoid; E0VLF5; -.
DR OMA; SCFKEPS; -.
DR OrthoDB; 2907766at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR Gene3D; 1.20.120.770; Amyloid precursor protein, E2 domain; 1.
DR Gene3D; 3.30.1490.140; Amyloidogenic glycoprotein, copper-binding domain; 1.
DR Gene3D; 3.90.570.10; Amyloidogenic glycoprotein, heparin-binding domain; 1.
DR InterPro; IPR036669; Amyloid_Cu-bd_sf.
DR InterPro; IPR008155; Amyloid_glyco.
DR InterPro; IPR011178; Amyloid_glyco_Cu-bd.
DR InterPro; IPR024329; Amyloid_glyco_E2_domain.
DR InterPro; IPR008154; Amyloid_glyco_extra.
DR InterPro; IPR015849; Amyloid_glyco_heparin-bd.
DR InterPro; IPR036454; Amyloid_glyco_heparin-bd_sf.
DR InterPro; IPR019744; APP_CUBD_CS.
DR InterPro; IPR036176; E2_sf.
DR PANTHER; PTHR23103; ALZHEIMER'S DISEASE BETA-AMYLOID RELATED; 1.
DR PANTHER; PTHR23103:SF15; AMYLOID-BETA-LIKE PROTEIN; 1.
DR Pfam; PF12924; APP_Cu_bd; 1.
DR Pfam; PF12925; APP_E2; 1.
DR Pfam; PF02177; APP_N; 1.
DR SMART; SM00006; A4_EXTRA; 1.
DR SUPFAM; SSF56491; A heparin-binding domain; 1.
DR SUPFAM; SSF89811; Amyloid beta a4 protein copper binding domain (domain 2); 1.
DR SUPFAM; SSF109843; CAPPD, an extracellular domain of amyloid beta A4 protein; 1.
DR PROSITE; PS00319; APP_CUBD; 1.
DR PROSITE; PS51869; APP_E1; 1.
DR PROSITE; PS51870; APP_E2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU01217}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 14..185
FT /note="E1"
FT /evidence="ECO:0000259|PROSITE:PS51869"
FT DOMAIN 302..500
FT /note="E2"
FT /evidence="ECO:0000259|PROSITE:PS51870"
FT REGION 14..119
FT /note="GFLD subdomain"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01217"
FT REGION 127..185
FT /note="CuBD subdomain"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01217"
FT REGION 192..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..269
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 95..102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01217"
FT DISULFID 129..183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01217"
FT DISULFID 140..170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01217"
FT DISULFID 154..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01217"
SQ SEQUENCE 501 AA; 57601 MW; F4D9B8FBD9B27C8C CRC64;
MKAGAISPTE TPAAHFEPQV AILCESGSGS EQQKTQAYHS QYMTEQGKWI TDINNKATCL
KDKMDILDYC KKVYPKRDVT NIVEASHYLK VPNWCKVGHK KCKISRWVKP FRCLEGPFQS
DALLVPENCL FDHIHNQTKC WEFSKWNLTA SQSCQEREMQ LRSFAMLLPC GISLFSGVEF
VCCPKHLKDN MKPKKPLDVI PMPVKEDEES PDEADDDDDQ NDDDDDDDGD DDDQIVDDNA
QDDAEEMQGD DPGEEDDDDD DDDEDYSDGS ESSTTAKPKS GSGSSSSLPH HRTSTPKSGP
PTPDPYFTHF DPRIEHQAYK EAQLRLEELH REKVTKVMKD WSDLEERYQD MRTSDPKAAE
EFKKRMTQRF QRTVQSLEDE GNAEKHQLVA MHQQRVMAHI NQRKKEAMTC YTQALNENPP
NAHRVQKCLQ KLLRCLHKDR HHTIAHYKHL LSSSFEQAER EKSITLEHLT DIDRMVNQSL
QMLQRQVGFI NQITVVKSNL D
//
