ID E0VLI3_PEDHC Unreviewed; 749 AA.
AC E0VLI3;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Hormone-sensitive lipase, putative {ECO:0000313|EMBL:EEB14239.1, ECO:0000313|EnsemblMetazoa:PHUM288260-PA};
DE EC=3.1.1.79 {ECO:0000313|EMBL:EEB14239.1};
GN Name=8229601 {ECO:0000313|EnsemblMetazoa:PHUM288260-PA};
GN ORFNames=Phum_PHUM288260 {ECO:0000313|EMBL:EEB14239.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB14239.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14239.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB14239.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14239.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM288260-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM288260-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; AAZO01003345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235271; EEB14239.1; -; Genomic_DNA.
DR RefSeq; XP_002426977.1; XM_002426932.1.
DR AlphaFoldDB; E0VLI3; -.
DR STRING; 121224.E0VLI3; -.
DR EnsemblMetazoa; PHUM288260-RA; PHUM288260-PA; PHUM288260.
DR GeneID; 8229601; -.
DR KEGG; phu:Phum_PHUM288260; -.
DR CTD; 8229601; -.
DR VEuPathDB; VectorBase:PHUM288260; -.
DR eggNOG; KOG4388; Eukaryota.
DR HOGENOM; CLU_010288_1_0_1; -.
DR InParanoid; E0VLI3; -.
DR OMA; CKETQFA; -.
DR OrthoDB; 2941058at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0033878; F:hormone-sensitive lipase activity; IEA:UniProtKB-EC.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR InterPro; IPR010468; HSL_N.
DR PANTHER; PTHR23025:SF3; HORMONE-SENSITIVE LIPASE; 1.
DR PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR Pfam; PF07859; Abhydrolase_3; 2.
DR Pfam; PF06350; HSL_N; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EEB14239.1};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 10..312
FT /note="Hormone-sensitive lipase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06350"
FT DOMAIN 332..481
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT DOMAIN 630..692
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
SQ SEQUENCE 749 AA; 84376 MW; 6898ED82F69A4E5F CRC64;
MEEPFGNAYI DELLHICSKN AEHYEKDISE YGQRMVLGFI GIIDHVNLIV PLVNNIKEVM
SDFDFDEKTP GNGYRSFVAV VHSSFKHAFE LSNYIAANKD SIIFRKGFYV KEVEAISRLI
ASLLSCLKYL EILLSWSNTG DLFPSAEHFS DILIQQSENI NQFAFYGRCM GIQFCSSVQP
VLKFISIFMA SFSEIYYNFG GFSAKALSLF SGSKFLIDPE LRAQRIVNIS QNASIDFCKS
FWFLTESELM KKIPDFICRS LAINHQIKIP SEPLSILNLN GEEIEIPIPS SHIPVNSIQV
RLLSRSRRQG MNYGTSDGNK KGKFNPPSKS LILHCHGGGF VAQSSKTHEV YLRDWANELD
VPIISVDYSL APEAPFPRAL EEVFYTYCWI LKNSHLLGST GENIILAGDS AGANLILGTT
LKSIEYNIRK PSGLFVAYVP VIVSSTPSPS RLLCLMDPLL PLGFLLRCLK AYACPDFEVD
QKGVPTAEEY NNKIHSDGTS TTCDKKLVCD IENSDSSSSG SRGRREKEFY ECVVSNENYT
LEKNSEDWEE EKKLNEANII LNSSMTGSQK RTMMMNENSG STLNFFKRKI SDFLGNAFFK
TETKNYCFDK MDFIESNYTN SLKNLKFSVP KDPYLSPYWA PDDMLNQLPP TSICSVQFDP
CLDDCVMFAK KLKKLGITVT LDILEGLPHG FLNLCKINKE AESGSKFCLQ RIKELINTGE
GNLNNGKDTS TPYKNYIIDN KSQSMIDFQ
//
