ID E0VMX5_PEDHC Unreviewed; 2598 AA.
AC E0VMX5;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE SubName: Full=Fetal alzheimer antigen, falz, putative {ECO:0000313|EMBL:EEB14731.1, ECO:0000313|EnsemblMetazoa:PHUM320320-PA};
DE EC=2.3.1.48 {ECO:0000313|EMBL:EEB14731.1};
GN Name=8236106 {ECO:0000313|EnsemblMetazoa:PHUM320320-PA};
GN ORFNames=Phum_PHUM320320 {ECO:0000313|EMBL:EEB14731.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB14731.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14731.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB14731.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB14731.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM320320-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM320320-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; AAZO01003719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235327; EEB14731.1; -; Genomic_DNA.
DR RefSeq; XP_002427469.1; XM_002427424.1.
DR STRING; 121224.E0VMX5; -.
DR EnsemblMetazoa; PHUM320320-RA; PHUM320320-PA; PHUM320320.
DR GeneID; 8236106; -.
DR KEGG; phu:Phum_PHUM320320; -.
DR CTD; 8236106; -.
DR VEuPathDB; VectorBase:PHUM320320; -.
DR eggNOG; KOG1473; Eukaryota.
DR eggNOG; KOG1632; Eukaryota.
DR HOGENOM; CLU_000284_0_0_1; -.
DR InParanoid; E0VMX5; -.
DR OMA; PEQYTNV; -.
DR OrthoDB; 2878869at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016589; C:NURF complex; IEA:InterPro.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd15559; PHD1_BPTF; 1.
DR CDD; cd15560; PHD2_3_BPTF; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR PANTHER; PTHR45975:SF2; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 3.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:EEB14731.1};
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:EEB14731.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 196..256
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 347..394
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2369..2420
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2425..2476
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2503..2573
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1791..1834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1944..1964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2114..2160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2246..2271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2315..2364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 999..1034
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 38..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..144
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2130..2160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2315..2333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2598 AA; 294919 MW; 313D32464458A723 CRC64;
MTGRPARKRG RPPKAVVLER PKKFQYHLLK KPKYLLNQEN KGSETPNSQD STPTHSRGAS
PDISDISNKN SRSFRHKQRL SYGSVSKRGG KSVNYGRHYN FKSAAEKSSD YHYGSDFEDD
FEEMKSESEM DDNIDIDPDA VLSDDCDSDS SNHSSDLPKN KVSYIKPPSP DPLWLQEIDL
PPLDLPKSSE DLLVPKEYIM KTLSIYEVLR HFRNLARLSP FRLEEFCGAL MLEEQNVLLV
EIHIMLLKAI FREEDSQQTH FGPLDQKDSV NACIYFIDPM TWPEVLRSYV ESDKSFDHSI
LDILIPGDYP FCGVEKRLKV LQFLTDQFLV TNPVREDLIS EGPIHYDDHC RICHRLGDLL
CCETCPAVYH LECVEPPLND VPEEDWQCNI CKSHRTSGVT DCIIPAEKTG TLSRHEHLGF
DRHGRKYWFL CRRIFVEKDD GEVWYYSTKY QLDELLDKLD ENSMEKTLYR EITNLKDVIL
KHMSITETVT NSAKAGRKSY LEVENAEEMN RILAESERTD QNEIPTLAGE AEIETEEVPL
ALQELENLRL TRYRAQQIAS GTFLFKLGQD NNCKNYVNQY TSNIYALNKP QRNEERDKKR
HLSHKFSLTA ASEFKWAGSV FGPKALLINT LRQTILQLES NIPTSFLHVN WPLLRKTWIA
CVQSCIQPKD FGKALVVLQA CIKPVVYASV WHEQLGHVRL HRVTAIEREE RKKIEKREKK
EKEDEEERNR LAINFVKYTL GLKHSVQKQK GEEYRIHGQW GWRWLSSTRK LIIKDARTMG
LRAGPQKIMV QVKDGIKEVS NESNQQEWSK ESETDKRLNN LRVFRPIMEF ETIDVTKALT
SPGRLQYPKI AKKSKLDDFL LRRSNLKLLE ERKFIQMGMV ANSSCQEMDS KKLDSDIDVE
ALDEDKKNFD FASSSTNQDK LIEIAQEILV CKKRYKEVST SKTLCYSVSC RNNSSGVLLC
YSPLCILQNA LKAKLATLLK SAQEITDSQT LQNVLITTEK NMKNVKENAT GELNEAAKKE
LVNAVATAKN VEDDSIDFSK VSSKLEVKEE VPESYLEEEV ISMDTVICGE EVVTTDDTMK
KEEEIDIEND SPNKIIGFDS GQTIKSNMIT NGQAVKSEGL LNKILSVKKT EVSEDLKQNV
KGGLSKSGLD NFKVLEKVKL EDGSEVERVY SVTDTRGKIY LKKLTTAIVD RRRKKTPVKY
PLYSTFLSKH GQYSLMILPK SELRKLARNG GKLTVNGFHH LAKSNTWQWP YPNSKPLFKT
CWLYRTTTIQ SIPAISLQLR ILWACLRWDD MQVKPQSTDG KNQVTTDTEI MTLEILKHRH
LGENLEKTQY LRRKIVIPLE LPKTIREVNP IRSGLRKRKR EETPQNTEPQ VSEEWVDEDK
LELWEIKQYC DKLEKTNNMT LTRSRTGTLT PKTEIKIEAS TIKAENIITK GTPEEIKEKM
EMQLRAQRAA HYQKKSVETM VKTTGGQIIK LLPATRKIYM SKDGTAKVVT SPATLVQKTT
AAGNLQQSLI KIQPQTDQHT FSIQGGHPQR VQIIRGNDGK IQVRGLVPGQ QLIQMADGKL
HVLTGQISSQ TQPSTTVGGQ STLVQTPSNT KITRTEGSGI TSPAQIIVKN AQGQQVRVVP
SGQNLKQQLQ QNFHKSIILK QDGTKVVLSQ PQQTTQNIFA GQTFTPNSVV MRGNQVIGTT
NEKGQVVITS RVQNLIPRND KTQSNVAISN QRPIAVSVSN ASTTSLASTV VQNSTLNSGT
VNQTDAPALI QSGSVVVNNP VLAQQLAEGK LQLATLNGQQ VLIRTTSTNN ALNTNSQTSA
TTNHLQKLLS PTKSAQSSSP STPKSSNVQV SATQDTPISS QNYCKTQTGL IQITQKDENS
ESNIMTEEIP SRQLVQQQLR QQVLRNQRTA SAKLSVSSNQ KILQSRLQGS LEQNVNSEMI
EKTSNESIVE SSAEFNQEMD AIENSDSNNE SQVEMRNQSA ETQENNPLAS TVLVDHNSEI
ERQLLVSQPP GTIIKCVTAQ VIQTSEGPRI VLQGIQGADF TPQQLNLVQQ QVKQQLLKNQ
ATTGKQGVLG PTKIYLAVQP PPQTNQSGNS PVNEETLLTP QNQKILVKQN TAKKTLSGNQ
SVIVRQNANS HIENVAENLE TEETTDTDNN SKQMEASPTK DNSAAETLPK ENCENQTPDG
QQQKKFILTH DYIHQTIKNA LKQENLNPEI EEKLIQLQRY QEKQMKNEPV NPVITRPQPR
KRPSSVQGNN HDYEISLLKI FSPTKADGID EKNSRSRQKW KENQEEKRRQ AAQSKLNVLL
FRHKELLKKD ILKKRALLEK ELQIDIQREI SVELSSRSKQ HENKTEEVIR TGSGKRKSVP
VPAAALQPPK SGSRGVSGRP KNQTGKKEKL YCVCRTPYDD TKFYVGCDLC HNWYHGDCVG
ITESMSKRMT EFVCTECRHA RETKELYCLC KQPYDESQFY ICCDKCQDWF HGRCVGILQS
EADNIDEYIC PNCQVDSNIN FANMKKLNNR DYEALKKLVK QMQGHKSAWP FMEPVDPTEA
PDYYKVIKEP MDLQTVELRI NEKHYKNLSE FIGDVTKLFD NCRYYNSKES PFFRCAEGLE
SFFVQKVKGL REKIVENK
//
