ID E0VPZ1_PEDHC Unreviewed; 1051 AA.
AC E0VPZ1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Diaphanous, putative {ECO:0000313|EMBL:EEB15447.1, ECO:0000313|EnsemblMetazoa:PHUM368970-PA};
GN Name=8233565 {ECO:0000313|EnsemblMetazoa:PHUM368970-PA};
GN ORFNames=Phum_PHUM368970 {ECO:0000313|EMBL:EEB15447.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB15447.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15447.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB15447.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15447.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM368970-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM368970-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR EMBL; AAZO01004291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235379; EEB15447.1; -; Genomic_DNA.
DR RefSeq; XP_002428185.1; XM_002428140.1.
DR AlphaFoldDB; E0VPZ1; -.
DR STRING; 121224.E0VPZ1; -.
DR EnsemblMetazoa; PHUM368970-RA; PHUM368970-PA; PHUM368970.
DR GeneID; 8233565; -.
DR KEGG; phu:Phum_PHUM368970; -.
DR CTD; 8233565; -.
DR VEuPathDB; VectorBase:PHUM368970; -.
DR eggNOG; KOG1924; Eukaryota.
DR HOGENOM; CLU_002356_0_1_1; -.
DR InParanoid; E0VPZ1; -.
DR OMA; VTKMSIF; -.
DR OrthoDB; 1118745at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR010465; Drf_DAD.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR Pfam; PF06345; Drf_DAD; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 49..408
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 569..968
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 988..1020
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 18..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 434..475
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 849..911
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 495..563
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1051 AA; 119731 MW; 82DA0B4A34675AF5 CRC64;
MSKQEKLKSS GKFLDSLFVR PKKGNRSSVV SRPTSDSEYN DNELQEAILN TMDENKINEK
FEEMLQDMNL SEERKQPLRE MALMNKRKLL ISHWKNSVQQ DNKSKFDKPS DYIAFLSTPE
LSLNKRYSCV ESLRIALTNN PLTWVQEFVT EGLQLLLGVL NECYLNDPRH EKVQYECLRC
LRAIMNNTIG IKKVFGQKGA MTVLARSLDI TKPKVMFEVV QVLAATCFIP PVGHDKVVEA
ITMSGEIKGK ERFQPIVQGL LAKNNENLRV ACLTLINAIV TQTDDLEYRL HLRNEIMRAG
LYDVLEDLEK DAPEDLIVQI NVFNEHKETD FAEWVEKFDS TVRLEFDDVN ECFDMLKNLV
MESPAEPYFL SILQHLLFIR DDHLIRPAYY KLIEECVSQI VLHKGGCDPD FRANRRFQID
VAPLIDHLVE KESKAEDEKK LADLKNKLEE AILQRQESEA RYLQLEKRLQ EIEQDGSSMN
LSETAKLIQS KLPPGKIGGP PPPPPPPMPG GGPPPPPMPG ISGGPPPPPM PGAGPPPPPL
PGMIPPPPGG LLGPSPMKPP DVLPYGLKPK KKWDTIRPIK RANWKAIIPQ KLSEKSFWVK
VQEEKLASPD ILEGLSEKFS TKPVLKKVED DTEGMGTLKR KNELKVLDSK SSHNISILLG
GSLKHLSYKD VRKCILRCDE TALTENILKQ LIDYLPPPDQ LGKLKDFISQ YDSLTEAEQF
AVTISDIKRL HPRLKSLSFR QRFPEIVQEI KPDIVAGTAA CEEVKRSNKF ARILELILLL
GNYMNSGSRN GQAFGFEISF LPKLTSTKDV ENKTTLLHFL VETIEKKFPE LLNFHEQLEH
VDRASRVSMD NIQKTLRQMD SSLKNLETDL QNSKVPQCDD DLFYTSMSSF AKEARQQCEI
LQNMFKNMES LYSDLAEFYA FDKTKYTLEE FFGDIKEFKD LFLQAHKDNV KQRETEEKLR
RARESREKQE QEKQARAARK KALIDINTQT QEGVMDSLLE ALQSGSAFTR DQRRARANPR
VAGAERRAQL NRSRSRTGLV VNAMLAREIA K
//
