ID E0VQN4_PEDHC Unreviewed; 586 AA.
AC E0VQN4;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=FERM domain-containing protein, putative {ECO:0000313|EMBL:EEB15690.1, ECO:0000313|EnsemblMetazoa:PHUM380350-PA};
GN Name=8237218 {ECO:0000313|EnsemblMetazoa:PHUM380350-PA};
GN ORFNames=Phum_PHUM380350 {ECO:0000313|EMBL:EEB15690.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB15690.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15690.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB15690.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15690.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM380350-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM380350-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell projection, rhabdomere
CC {ECO:0000256|ARBA:ARBA00043944}.
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DR EMBL; AAZO01004443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01004444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235430; EEB15690.1; -; Genomic_DNA.
DR RefSeq; XP_002428428.1; XM_002428383.1.
DR AlphaFoldDB; E0VQN4; -.
DR STRING; 121224.E0VQN4; -.
DR EnsemblMetazoa; PHUM380350-RA; PHUM380350-PA; PHUM380350.
DR GeneID; 8237218; -.
DR KEGG; phu:Phum_PHUM380350; -.
DR CTD; 8237218; -.
DR VEuPathDB; VectorBase:PHUM380350; -.
DR eggNOG; KOG3530; Eukaryota.
DR HOGENOM; CLU_003623_1_7_1; -.
DR InParanoid; E0VQN4; -.
DR OMA; YCSLGEA; -.
DR OrthoDB; 2912597at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17102; FERM_F1_FRMD3; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF32; FI22325P1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 517..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..295
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 441..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 67662 MW; 57DE0A31A78239F0 CRC64;
MVKFYYKTVN NSNHKCTIRL LDDTEILECE FQSDHKGLNL LNYVCQQLNI IEKDYFGLRF
VDIAKQRHWL DLKKPILKQV REMNPVLFSF RVKFYPPNPA NLSEETTRYF LFLQLKRDLL
HGRLYCSQNE AALLAAYIVQ AELGDYDPEI CIGNYVSNIK LLLKQTLPIE KQILEIHQTQ
LKGQSSSAVE LLFLKKACQL ETYGVDPHVV KDHKGNTLYV GINHLGVLTF QGSKKTRQFN
WSEIQKINYE GKMFIIHLVF YEKKHTVGFR CSTTSGCRYL WRCAVEKMLF FTLKKAADAP
VMTGGGFFSW GTKFKYFGRT EKEILQDTLF RKIKEPDVSL NGNLMRKSCS VPATPCTPAG
SDLSEMRCRS LPKADHYMFY SKLHPDYPPI FGDCPKNSLP CLQIVSTSQD HDLGKSRVQD
FRDLNECDDY YFRDSFDRSS CDSQSHTNKT TTITSSQKCS RNHSPLHSGS GTTHGTGSKI
LSPKRDVTHN PLLQLSDNHQ DIQNSINTKN DITKFNLFQV FIPSFLFVVI SLITATIIIM
ESDSDLVKNV NNLPEMISLR KHYYEPMKNF FANRFLKFMF KKEVKH
//
