ID   E0VR22_PEDHC            Unreviewed;      1239 AA.
AC   E0VR22;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=BTB domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=8237571 {ECO:0000313|EnsemblMetazoa:PHUM390830-PA};
GN   ORFNames=Phum_PHUM390830 {ECO:0000313|EMBL:EEB15828.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC   Pediculus.
OX   NCBI_TaxID=121224;
RN   [1] {ECO:0000313|EMBL:EEB15828.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB15828.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB15828.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB15828.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:PHUM390830-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM390830-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
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DR   EMBL; AAZO01004572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS235442; EEB15828.1; -; Genomic_DNA.
DR   RefSeq; XP_002428566.1; XM_002428521.1.
DR   AlphaFoldDB; E0VR22; -.
DR   STRING; 121224.E0VR22; -.
DR   EnsemblMetazoa; PHUM390830-RA; PHUM390830-PA; PHUM390830.
DR   GeneID; 8237571; -.
DR   KEGG; phu:Phum_PHUM390830; -.
DR   CTD; 8237571; -.
DR   VEuPathDB; VectorBase:PHUM390830; -.
DR   eggNOG; KOG2714; Eukaryota.
DR   eggNOG; KOG3715; Eukaryota.
DR   HOGENOM; CLU_266903_0_0_1; -.
DR   InParanoid; E0VR22; -.
DR   OrthoDB; 5312378at2759; -.
DR   Proteomes; UP000009046; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   CDD; cd18363; BTB_POZ_KCTD3-like; 1.
DR   Gene3D; 3.40.50.12430; -; 1.
DR   Gene3D; 1.10.10.1730; Folliculin; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR037521; FLCN/SMCR8_DENN.
DR   InterPro; IPR044886; FLCN_DENN_C_sf.
DR   InterPro; IPR037520; Folliculin/SMCR8_longin.
DR   InterPro; IPR032035; Folliculin_DENN.
DR   InterPro; IPR047876; SHKBP1/KCTD3.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR15859:SF1; BTB DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15859; SETA BINDING PROTEIN 1; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF11704; Folliculin; 1.
DR   Pfam; PF16692; Folliculin_C; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS51834; DENN_FLCN_SMCR8; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          81..150
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
FT   DOMAIN          828..1239
FT                   /note="UDENN FLCN/SMCR8-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51834"
SQ   SEQUENCE   1239 AA;  140150 MW;  6D045F9E5A53A9FC CRC64;
     MNAIFSLSHF CETHGPTVLL STQAFHFAGE DHSGTIEPLG VQFFGCVQKL KAYNGSSVFE
     NLKNTKCEAI MAASHPSHVG DIVHLNVGGT RFSTSRQTLT WIPDSFFTAL LSGRIPSLRD
     ETGAIFIDRD PQNFSIILNY LRTKDINLQI TDLRILRQEA EYYGITPLVK RLLLCEDITQ
     SSCGDVLFYG LLPQPNFPLH DATENLKKNH ELLAENHFSH PNTNPLSSSA TLMPLPCHSN
     ESAVQQPLHY FNEHSKVNSN AFKNVPLDAK TASYGSTSSC NSNCSSNELR IMASKTVNLH
     SRNASLDLKH SRNSSLDFNK TIKNENGMVS LNYHPDFWAD PMRVRTIRAH HNWISVAYAH
     FVTCFHLKDS SGWQHVFTSP YIENCIEHIA INAKINQGAN GDYLKMVAIS CGSQIYLWNI
     LEDGGKINVG TFKLNVRVEY LFFIGSQLVA LSLSGKIGVW HSMTQHWQIQ DVLPITSFDT
     AGSFLLLGCS NGSIYYIDMQ KFPLRMKDND LLVTELYRDP SKDPITAISV YLTPKTSICG
     NWIEIAYGTK SGVVRVIAQH PETVGHGPQL FQTFTVHQNP VIKVSLSEKF LISVCSEYSH
     VRTWNVNRFR GMISTQPGST PMASFKIISL DATDSFVGYV TKNDCGPFGE QDDEQVFVQK
     VVPESDKLFV RLASNGKRVC VITSVDGTVI TSFCVHECEG SRRMGSRPRR FIFTGHSNGT
     LQIWDLTLAL ELANKNESLT QISGGPTSTE LLRLLDQCEL SNSLCSTPCI SPCPWTSTSS
     TRLKSSNTMF LTQNQESQSH IKDSETWNKN ATLLNQCILF NFIIIIDVIA CESTSGFISN
     DYKNKISFIS ARLSIDSNVT LLLKQGAIRS LSCEVIPGKE GLVYFGDSSR GHFLSNAFCL
     KDAQARGFHR WYSIVIYMKD KHLLLNSWPF FEKYMHKLIV DLQTKASQVF TQEQNMCSQR
     KLRLSGIKSN HSTTRSLVKL TGSPHVFAQL HLWFSWLLST GGKRLEENTP MRMLNTRSDT
     SHKVDTFDKK SRTIDKLDDF IWHLRKLRNI FGKYNFQKII YSTLIGRQII VRGPKEFVGL
     LLNILKLFLP SCKSSLIKYD EKYKCRDISS IIGLSLYAAV PKSCYNLLRL DIVPHQTCDY
     FIDSNNDDYD RYNFILKCEN KLPEKLPTLL VKIDKALADD TLSDKVVWLH VYSLLEQWFH
     TAEVLKEANK KCNEIYYSSL MQFLGIKEHD KNLIKFWTT
//