ID E0VR32_PEDHC Unreviewed; 630 AA.
AC E0VR32;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Calcium-binding mitochondrial carrier Aralar1, putative {ECO:0000313|EMBL:EEB15838.1};
GN Name=8237581 {ECO:0000313|EnsemblMetazoa:PHUM391230-PA};
GN ORFNames=Phum_PHUM391230 {ECO:0000313|EMBL:EEB15838.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB15838.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15838.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB15838.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB15838.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM391230-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM391230-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBUNIT: Homodimer (via N-terminus). {ECO:0000256|ARBA:ARBA00038674}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
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DR EMBL; AAZO01004575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01004576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235442; EEB15838.1; -; Genomic_DNA.
DR RefSeq; XP_002428576.1; XM_002428531.1.
DR AlphaFoldDB; E0VR32; -.
DR STRING; 121224.E0VR32; -.
DR EnsemblMetazoa; PHUM391230-RA; PHUM391230-PA; PHUM391230.
DR GeneID; 8237581; -.
DR KEGG; phu:Phum_PHUM391230; -.
DR CTD; 8237581; -.
DR VEuPathDB; VectorBase:PHUM391230; -.
DR eggNOG; KOG0751; Eukaryota.
DR HOGENOM; CLU_014931_3_0_1; -.
DR InParanoid; E0VR32; -.
DR OMA; GPDAIPF; -.
DR OrthoDB; 1220009at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0043490; P:malate-aspartate shuttle; IEA:UniProt.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45678:SF9; CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1; 1.
DR PANTHER; PTHR45678; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF13405; EF-hand_6; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 53..88
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 124..159
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 288..379
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 387..471
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 479..567
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 630 AA; 70200 MW; 444D0E1D265EAD26 CRC64;
MTSDDFIRRY LGIFTSDDRN KESVSLLAGI VDPRKDGLIS FSEFQAFEGL LCLPDALYKT
AFQLFDINGN GMITFDEFSE VIKKTTLHQR VPFDMNGGFI KLYFGKDKTR VINYVEFGQF
LHDFHEEYAT EAFRRFDKDG TGFISAADFQ DIMVSIKSHL LTPQVEQNLM AVNGGHRVSF
PYFMAFNSLL NNMELIKRIY LNATNGNKLQ EVTKDEFLFS AQMMSQITPL EVDILFHLCH
LLYQSGKIVY NDLQVIAPEQ YFKHINKRLA EIHAVSSPEE RGVFIQVLES VYRFALGSIA
GAVGATAVYP IDLVKTRMQN QRSGSFIGEL MYRNSFDCFR KVIRHEGFFG LYRGLLPQLM
GVAPEKAIKL TVNDFVRDKF MDRHGNIALY GEIISGGCAG GSQVVFTNPL EIVKIRLQVA
GEIAGGSKIS AFSVVKELGF FGLYKGAKAC FLRDVPFSAI YFPAYAHLKA KFADENGYNH
PLSLLTAGAI AGIPAASLVT PADVIKTRLQ VVARAGQTTY SGVFDAAKKI YQEEGARAFW
KGTAARVFRS SPQFGVTLFT YEVLQRLFYV DFGGTRPAGS ELTLPETGVA EAMKSTNPDH
IGGYQVALPI LKGIETKFGL CFPKFSTTLS
//
