ID   E0VS67_PEDHC            Unreviewed;      1196 AA.
AC   E0VS67;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=Tubulin-specific chaperone D {ECO:0000256|ARBA:ARBA00015003};
GN   Name=8234284 {ECO:0000313|EnsemblMetazoa:PHUM411960-PA};
GN   ORFNames=Phum_PHUM411960 {ECO:0000313|EMBL:EEB16223.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC   Pediculus.
OX   NCBI_TaxID=121224;
RN   [1] {ECO:0000313|EMBL:EEB16223.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB16223.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB16223.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB16223.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:PHUM411960-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM411960-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TBCD family.
CC       {ECO:0000256|ARBA:ARBA00006853}.
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DR   EMBL; AAZO01005062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS235745; EEB16223.1; -; Genomic_DNA.
DR   RefSeq; XP_002428961.1; XM_002428916.1.
DR   AlphaFoldDB; E0VS67; -.
DR   STRING; 121224.E0VS67; -.
DR   EnsemblMetazoa; PHUM411960-RA; PHUM411960-PA; PHUM411960.
DR   GeneID; 8234284; -.
DR   KEGG; phu:Phum_PHUM411960; -.
DR   CTD; 8234284; -.
DR   VEuPathDB; VectorBase:PHUM411960; -.
DR   eggNOG; KOG1943; Eukaryota.
DR   HOGENOM; CLU_003043_0_0_1; -.
DR   InParanoid; E0VS67; -.
DR   OMA; EPHEAWH; -.
DR   OrthoDB; 5477080at2759; -.
DR   Proteomes; UP000009046; Unassembled WGS sequence.
DR   GO; GO:0048487; F:beta-tubulin binding; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR   GO; GO:0007021; P:tubulin complex assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033162; TBCD.
DR   InterPro; IPR022577; Tubulin_specific_chaperoneD_C.
DR   PANTHER; PTHR12658; BETA-TUBULIN COFACTOR D; 1.
DR   PANTHER; PTHR12658:SF0; TUBULIN-SPECIFIC CHAPERONE D; 1.
DR   Pfam; PF12612; TFCD_C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT   DOMAIN          889..1075
FT                   /note="Tubulin-specific chaperone D C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12612"
SQ   SEQUENCE   1196 AA;  136388 MW;  D0BC609B50F3B838 CRC64;
     MVETDTEEIL DEKETDNPGL ACALEYFAEY DEVLKLIGNL SNIYNDSKDV EINIEKFNFI
     LDKYQEQPHL LDPNLDKMLN ELIIIIKEKN NPENLKALAF RYIKHIMKVR GFKVVVRHLP
     HEVTDLEPVL QLLENQNKEC ISHWEASYVL LLWMSIIVKI PFHMSRLDSF QNEGETQKTV
     IERLLFICKN YILASSYFMN PAAFLTSHYI TRSDIKDKHL ENFLDWIFEK VQFESGADLI
     IQRNCLNSLV TLAAILKHGK REDLLPHAPA MLQKMLKCDY KESNNSLLRK YAMKVYQRIG
     LTFLKPKLAS WRYQRGNRFL ADNLKQDRVQ PTTVGGHGED VEGAIINDNE DFDVPEEVEE
     VIEQLMQGLK DSDTAIRWSA AKGLGRVTGR LPKELGDEVV GTVLELLNPR ESDRAWHGGC
     LTLAELGRRG LLLPQRLPVV VPLLLDALIY EDSRGYYSIG DHVRDAACYV AWSFARAYDA
     HIIKPFVNPI ANGLLAVTLF DREIKCRRAA SAAFQENVGR QGTFPHGIEI VTTADYFSVG
     IRQNSFLKIS VFVAKFEDYT LPLINHLVEK KVDHWDVAIR ELTASALHNL TPLVPDYLAE
     AILPILLAKT ELLNLNGRHG SIISIAEIVH ALSLLKKSID SENLEKIKNL IYLYKEKRYF
     SIVGGEIIRQ GFCTLIEKCA QSRLPFHQLP VIDELQSLMD ECLISEVPIV RAKAGGALPA
     FFEEYYQKNV GGVKIVLQEK CNKLVNNYIN ELSCLNQTAR LGYAMAIGNL PKFMIKGKVD
     ELVSALLESL KITEPTLKWA ESRRDSIKAL VSLISTIGLE MLYTESEEKK KDLESIYQNL
     LVCLGEYTQD TRGDIGAWVR ESAMSALEKM IIMTAKWNSK LLNESLMASI VGGIAQQAVE
     RIDRTRCLAG KLFGSILYHK DPVIPHIPYR EELLKIFPFE TCGNGALWRA ENESFPRFVR
     MLSFPCYTHN IMEGLILSIG GLTERLVKHS STSLFTYLKS IEDRKELDRI LNSIIDIFNT
     YLYNIRVILP LFIFLDRLLG SGVIREVLED NKSKFAEELY RLTKLEIARI RDYKKLVNSM
     DLFCQLVQVK GWVSTRALSQ MSVFLCHKLK AVRKSASSKL YECLLLYGDC TSIPEENLEE
     VMTILSDTNW ENEQNEVRPI RNKLCELMNV RIPRVLDKTT TATPTTAPTP TTTTEH
//