ID E0VSH1_PEDHC Unreviewed; 2123 AA.
AC E0VSH1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Myosin, putative {ECO:0000313|EMBL:EEB16327.1, ECO:0000313|EnsemblMetazoa:PHUM418650-PA};
GN Name=8234507 {ECO:0000313|EnsemblMetazoa:PHUM418650-PA};
GN ORFNames=Phum_PHUM418650 {ECO:0000313|EMBL:EEB16327.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB16327.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB16327.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB16327.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB16327.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM418650-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM418650-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AAZO01005132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235751; EEB16327.1; -; Genomic_DNA.
DR RefSeq; XP_002429065.1; XM_002429020.1.
DR STRING; 121224.E0VSH1; -.
DR EnsemblMetazoa; PHUM418650-RA; PHUM418650-PA; PHUM418650.
DR GeneID; 8234507; -.
DR KEGG; phu:Phum_PHUM418650; -.
DR CTD; 8234507; -.
DR VEuPathDB; VectorBase:PHUM418650; -.
DR eggNOG; KOG0248; Eukaryota.
DR eggNOG; KOG4229; Eukaryota.
DR HOGENOM; CLU_000192_14_2_1; -.
DR InParanoid; E0VSH1; -.
DR OMA; FDSKWMI; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13203; FERM_C1_myosin_like; 1.
DR CDD; cd13204; FERM_C2_myosin_like; 1.
DR CDD; cd17208; FERM_F1_DdMyo7_like; 2.
DR CDD; cd14883; MYSc_Myo22; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3; 1.
DR Pfam; PF00373; FERM_M; 2.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..640
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1044..1193
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1198..1529
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1610..1770
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1775..2086
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 521..543
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 722..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..865
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..911
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 51..58
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2123 AA; 244340 MW; 04516032C8333CC0 CRC64;
MKIILLLLQE YVFRYHGKKI GQLEPHVYAL AEAAHTSLKT CERNQSCVIS GESGAGKTET
TKFILQYLCS VTSNVSTWVE HQILEANTIL EAFGNAKTVR NDNSSRFGKF MQVCFDNKWM
IKGCIIQDYL LEQSRITFQS RGERNYHVFY QLLEGAKNNP ELTKQFHLKP PNFYKYLNQS
GCVQIEGVDD AKKLDVLRLA FNVVQVPAQM VDGIFAVISA ILWLGNLEFE DVDGEKCKLA
EEDKTVLATV SDLLKLNEQD LARVVLLRQI NVRGNITEIP LKLQEAKENR NAMAKALYSR
TFAWLVNHIN TCTNPGQDSS RFLGVLDIFG FENFLMNSFE QLCINYTNEK LHKFFNHYVF
ALEQEIYRQE KIEFSHIQFT DNSSCLELIE KPPRCILKLL TEQCHMPKGS DSAYLTNLHS
EFESHCYYVK GDDRRKWETE FGIRHYAGTV TYTVQGFVDK NRDVQQDVFF DFMSRSTNEF
IQEITVYQDL LGSTVAKMGG TMARGTTKGK PTVSDTFRYQ LQALVDVLQA TNPWYVRCIK
PNMEKSPNSY NEKLVLDQLK YLGMLEIIRI RKEGFPVHML FSDFVQRFKC LSKTRLSNDL
KEATSAIINT HNISKTEWQI GQTKVFLRFR AYDPLEDSRQ KILNACAILI QRTWKGFVVR
KSFKRKRSAV LKLQHAYRGW KQRIQFIKMR RAAIVIQSHL RGVFAREVAA ALREMRRVEE
EMRKREKLEE ERKKREAEEE EERKKNYLEE LERATQEQIE ALNQIAEQIN PKLMSTDHCG
DSVDLDNLFA FLSDMQPGSR HNIIEEISSH MEDLVEDLDV ELESVIQQEL EGLTNGISNV
DVRLRKNPSL PEPTMPPPPP PFTNGTGKPS AIVIPKTGEK SGNEPIYESV IPRDESNSSP
PPLPTPPQKI RPKSPSVDHV QRNSLERSTS PRPRPPGSPQ CHSRPNSRSS SGVPQNWKTH
REEDLEKEQR RKFRVEKKLQ ELEEDDKERV ANDVDDSYHD IVEFAQNFFN AHERSPEGTI
MATLTRKTRK SMEMMPKYEM VTYYKGNTIP NSHIHMYDPD NVTVACAIFR DLCKFLRGEL
KPETEVATIQ TIVGHGIERE ELRDEIFVQC IRQVTNCPQT EWMERIWLLL CLCIVSFQPS
KHLYKYFVCF LKKNLSLDGK LRQYVQWCLD NCNNNRVTNR TFPPSAVEIS AMKRLGTIVC
RFFFLDGRTK AIDVHPTDTA ADAVVKLSDK LGLRNIEGWA IYESRLDGEE HVKAHDYLYD
VIAAWEQKQN KAGNNNNNNT SFPSLSRRGN QTTLNPGENR FIFKKRLFRN SRTLSQDPVE
INMLYAQAVH SVVKADDFPV SEKVALQLAG LQAQVALGDP RPDNNKLTDY YAGVDTYLPY
RISKSRGEDV WISIISEAHS QYGTGRSELT AKALYLSCVM QYPLYGTTMY PVTYRGYWSY
GNNLILGVNC SGLMLIKPDD KFVLYEYRYQ NIESIFLDPS DSFITINLMR QIPDNTHKCF
VFETPYKNEI GSLIVSYCPA LANWIIENEA AVRKVKAITN EDRTRLYNNL VNARKNLVES
DLLRKSVEPG GGFIRSTLRR LSKSRIEKLR ADYGGEGEGV KGYPYTFWAF SKQPLTQSFS
KIPESDEQIA LQVFQLILNY AGLGQNGDII RRAEDEHVNL LQTIMERCMR KDVLLNELYL
QLIKQTTDHP DPNSRVNLRH WALLSLACSV ALPPHKQLRK YLIAHLKRCA SDCITEEGKY
ARFAEKCLYR TQGTRRRQWP PSKEEIMCTI NRRPIYARFH LMDGQYHAIE FLPSATAREV
MDVMKSKIGL KESAMGYAIY EVLGSSERSL VPDEKVADVM SKWERYRTAT AAQANTPANG
TNTIQLRVSR KQQHFFLFKK HLFLDQYMNL EDPVEKELLY HQVLHGLRCD RFPISEQEAV
MLTALQAQLE LGDCGDILLD YRGVASHCLA PRFVPNVPHE CVAMHHQSLH GMTQPEAKKS
FLNLIQSWPL HRATIFDVMQ SFTSNWPRVL WLAVDQTGLH LLEHRSRNAL VTYDYESILS
YSPALNCLMI VTGSERKQSK VILTTSQAFQ IANLIKEYCE VLQGGCENKD ILRRRDGQQQ
HQYSSRPMSI LHKPAPIIEQ AAS
//
