ID E0VTG1_PEDHC Unreviewed; 1030 AA.
AC E0VTG1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Unc-13, putative {ECO:0000313|EMBL:EEB16667.1, ECO:0000313|EnsemblMetazoa:PHUM432180-PA};
GN Name=8230263 {ECO:0000313|EnsemblMetazoa:PHUM432180-PA};
GN ORFNames=Phum_PHUM432180 {ECO:0000313|EMBL:EEB16667.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB16667.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB16667.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB16667.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB16667.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM432180-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM432180-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; AAZO01005270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01005271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235764; EEB16667.1; -; Genomic_DNA.
DR RefSeq; XP_002429405.1; XM_002429360.1.
DR AlphaFoldDB; E0VTG1; -.
DR STRING; 121224.E0VTG1; -.
DR EnsemblMetazoa; PHUM432180-RA; PHUM432180-PA; PHUM432180.
DR GeneID; 8230263; -.
DR KEGG; phu:Phum_PHUM432180; -.
DR CTD; 8230263; -.
DR VEuPathDB; VectorBase:PHUM432180; -.
DR eggNOG; KOG1011; Eukaryota.
DR HOGENOM; CLU_001304_2_1_1; -.
DR InParanoid; E0VTG1; -.
DR OMA; NCYELYQ; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd04027; C2B_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF12; UNC-13, ISOFORM E; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 45..95
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 151..275
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 583..726
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 836..1002
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
SQ SEQUENCE 1030 AA; 117302 MW; 9F1001C31609A9A4 CRC64;
MAATKRNAGL TSAVPRATLN DEELKMHVYK KTLQALIYPI SSTTPHNFLL WTATSPTYCY
ECEGLLWGIA RQGVRCTECG VKCHEKCKDL LNADCLQRAA EKSSKHGAED KANSIITAMK
ERMKQREREK PEIFELIRSV FGVDEKSHIG YMAAVKQSVL DGTSKWSAKI AITVICAQGL
IAKDKSGTSD PYVTVQVGKV KKRTRTMPQE LNPVWNEKFY FECHNSSDRI KVRVWDEDND
LKSKLRQKLT RESDDFLGQT IIEVRTLSGE MDVWYNLEKR TDKSAVSGAI RLHISVEIKG
EEKVAPYHVQ YTCLHENLFH SLCENNGGMV NLPRAKGDDA WKVYFDEAGE ELVDEFAMRY
GIESIYQAMT HFHCLSTKYL CPGVPAVMST LLANINAFYA HTTASSAVSA SDRFSASNFG
KEKFVKLLDQ LHNSLRIDLS MYRNNFPASS QEKLMDLKST VDLLTSITFF RMKVQELSSP
PRASTVVKDC VKACLRSTYQ FLFENCYELY SREFQVDPSE PKRDPNDNGP QLDSVDFWHK
LIALIVSVIE EDKNSYGPVL NQFPQELNIG QLSAATMWSQ FAIDMKYALE EHETHRLCKS
SAYMNLHFKV KWLHTNYVKD VPPYKGTVPE YPAWFEPFVM QWLNENDDVS LEYLHGAFNR
DKKDGFQKSS EHALFSNSVV DVFTQLTQCF DVVSKLECPD PEIWKRYMKR FAKTIVKVLV
AYADICKKEF PNFLKDERIA CILMNNIQQL RVQLEKMFES MGGDKLEEDA ANILKELQQN
LNSVLDDLAI VFASSLENQI TVSVRELGDL LLSIKGGGQV TLNQPAQRNA VAQEADEVLR
PLMDLLDGSL TLYAQSCEKT VLKRLLKELW KIVMRILEKT VVLPPMTDKT MILKNLTDNA
KNLAANAKIE DMSKLFRNHM AGKQDVKNAL SGVMDISKEV ERNLTPKQCA VLDVALDTIK
QYFHAGGNGL KKTFLEKSPE LQSLRYALSL YTQTTDALIK TFVTTQLNEE KKKNYRQNVL
FSRYRSIFPV
//
